Human Gene SAXO1 (ENST00000380534.9) from GENCODE V44
  Description: Homo sapiens stabilizer of axonemal microtubules 1 (SAXO1), transcript variant 1, mRNA. (from RefSeq NM_153707)
Gencode Transcript: ENST00000380534.9
Gencode Gene: ENSG00000155875.15
Transcript (Including UTRs)
   Position: hg38 chr9:18,927,650-19,033,209 Size: 105,560 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr9:18,928,052-19,032,908 Size: 104,857 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr9:18,927,650-19,033,209)mRNA (may differ from genome)Protein (474 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHPRD

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Protein FAM154A;
SIMILARITY: Belongs to the FAM154 family.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 37.04 RPKM in Testis
Total median expression: 37.75 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -120.80301-0.401 Picture PostScript Text
3' UTR -61.80402-0.154 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024963 - STOP/FAM154

Pfam Domains:
PF05217 - STOP protein

ModBase Predicted Comparative 3D Structure on Q8IYX7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGD  WormBase 
Protein SequenceProtein Sequence  Protein Sequence 
AlignmentAlignment  Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008017 microtubule binding

Biological Process:
GO:0009631 cold acclimation
GO:0030030 cell projection organization
GO:0045724 positive regulation of cilium assembly
GO:0050821 protein stabilization
GO:0070417 cellular response to cold

Cellular Component:
GO:0005737 cytoplasm
GO:0005814 centriole
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0005879 axonemal microtubule
GO:0005929 cilium
GO:0031514 motile cilium
GO:0036064 ciliary basal body
GO:0036126 sperm flagellum
GO:0042995 cell projection

-  Descriptions from all associated GenBank mRNAs
  AK057474 - Homo sapiens cDNA FLJ32912 fis, clone TESTI2006238.
AK292245 - Homo sapiens cDNA FLJ77589 complete cds.
BC033489 - Homo sapiens family with sequence similarity 154, member A, mRNA (cDNA clone MGC:35182 IMAGE:5170510), complete cds.
KJ900327 - Synthetic construct Homo sapiens clone ccsbBroadEn_09721 FAM154A gene, encodes complete protein.
JD144082 - Sequence 125106 from Patent EP1572962.
JD371457 - Sequence 352481 from Patent EP1572962.
JD322112 - Sequence 303136 from Patent EP1572962.
JD423408 - Sequence 404432 from Patent EP1572962.
JD392968 - Sequence 373992 from Patent EP1572962.
JD143942 - Sequence 124966 from Patent EP1572962.
JD494012 - Sequence 475036 from Patent EP1572962.
JD484666 - Sequence 465690 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C9orf138, ENST00000380534.1, ENST00000380534.2, ENST00000380534.3, ENST00000380534.4, ENST00000380534.5, ENST00000380534.6, ENST00000380534.7, ENST00000380534.8, F154A_HUMAN, FAM154A, NM_153707, Q5VY58, Q8IYX7, uc003zni.1, uc003zni.2, uc003zni.3, uc003zni.4, uc003zni.5
UCSC ID: ENST00000380534.9
RefSeq Accession: NM_153707
Protein: Q8IYX7 (aka F154A_HUMAN)
CCDS: CCDS6487.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.