Human Gene S1PR3 (ENST00000358157.3) from GENCODE V44
Description: Homo sapiens sphingosine-1-phosphate receptor 3 (S1PR3), mRNA. (from RefSeq NM_005226) RefSeq Summary (NM_005226): This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000358157.3 Gencode Gene: ENSG00000213694.7 Transcript (Including UTRs) Position: hg38 chr9:88,991,468-89,005,155 Size: 13,688 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr9:89,001,201-89,002,337 Size: 1,137 Coding Exon Count: 1
ID:S1PR3_HUMAN DESCRIPTION: RecName: Full=Sphingosine 1-phosphate receptor 3; Short=S1P receptor 3; Short=S1P3; AltName: Full=Endothelial differentiation G-protein coupled receptor 3; AltName: Full=Sphingosine 1-phosphate receptor Edg-3; Short=S1P receptor Edg-3; FUNCTION: Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99500
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.