Human Gene GADD45G (ENST00000252506.11) from GENCODE V44
Description: Homo sapiens growth arrest and DNA damage inducible gamma (GADD45G), mRNA. (from RefSeq NM_006705) RefSeq Summary (NM_006705): This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000252506.11 Gencode Gene: ENSG00000130222.11 Transcript (Including UTRs) Position: hg38 chr9:89,605,012-89,606,555 Size: 1,544 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr9:89,605,122-89,606,079 Size: 958 Coding Exon Count: 4
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95257
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000185 activation of MAPKKK activity GO:0006915 apoptotic process GO:0006950 response to stress GO:0007275 multicellular organism development GO:0030154 cell differentiation GO:0043065 positive regulation of apoptotic process GO:0046330 positive regulation of JNK cascade GO:0051726 regulation of cell cycle GO:1900745 positive regulation of p38MAPK cascade