Human Gene GRIN3A (ENST00000361820.6) from GENCODE V44
Description: Homo sapiens glutamate ionotropic receptor NMDA type subunit 3A (GRIN3A), mRNA. (from RefSeq NM_133445) RefSeq Summary (NM_133445): This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000361820.6 Gencode Gene: ENSG00000198785.7 Transcript (Including UTRs) Position: hg38 chr9:101,569,352-101,738,647 Size: 169,296 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr9:101,573,174-101,737,979 Size: 164,806 Coding Exon Count: 9
ID:NMD3A_HUMAN DESCRIPTION: RecName: Full=Glutamate [NMDA] receptor subunit 3A; AltName: Full=N-methyl-D-aspartate receptor subtype 3A; Short=NMDAR3A; Short=NR3A; AltName: Full=NMDAR-L; Flags: Precursor; FUNCTION: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity). SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Enriched in postsynaptic plasma membrane and postsynaptic densities. Requires the presence of GRIN1 to be targeted at the plasma membrane (By similarity). DEVELOPMENTAL STAGE: Expressed in fetal brain. PTM: N-glycosylated (By similarity). SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3A/GRIN3A subfamily. SEQUENCE CAUTION: Sequence=BAB85559.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00060 - Ligand-gated ion channel PF00497 - Bacterial extracellular solute-binding proteins, family 3
ModBase Predicted Comparative 3D Structure on Q8TCU5
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
