Human Gene UGCG (ENST00000374279.4) from GENCODE V44
Description: Homo sapiens UDP-glucose ceramide glucosyltransferase (UGCG), mRNA. (from RefSeq NM_003358) RefSeq Summary (NM_003358): This gene encodes an enzyme that catalyzes the first glycosylation step in the biosynthesis of glycosphingolipids, which are membrane components containing lipid and sugar moieties. The product of this reaction is glucosylceramide, which is the core structure of many glycosphingolipids. [provided by RefSeq, Dec 2014]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000374279.4 Gencode Gene: ENSG00000148154.10 Transcript (Including UTRs) Position: hg38 chr9:111,896,814-111,935,369 Size: 38,556 Total Exon Count: 9 Strand: + Coding Region Position: hg38 chr9:111,897,216-111,932,997 Size: 35,782 Coding Exon Count: 9
ID:CEGT_HUMAN DESCRIPTION: RecName: Full=Ceramide glucosyltransferase; EC=2.4.1.80; AltName: Full=GLCT-1; AltName: Full=Glucosylceramide synthase; Short=GCS; AltName: Full=UDP-glucose ceramide glucosyltransferase; AltName: Full=UDP-glucose:N-acylsphingosine D-glucosyltransferase; FUNCTION: Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase". CATALYTIC ACTIVITY: UDP-glucose + N-acylsphingosine = UDP + D- glucosyl-N-acylsphingosine. PATHWAY: Lipid metabolism; sphingolipid metabolism. SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein (By similarity). TISSUE SPECIFICITY: Found in all tissues examined. SIMILARITY: Belongs to the glycosyltransferase 2 family. WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF13506 - Glycosyl transferase family 21
ModBase Predicted Comparative 3D Structure on Q16739
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006629 lipid metabolic process GO:0006665 sphingolipid metabolic process GO:0006679 glucosylceramide biosynthetic process GO:0006687 glycosphingolipid metabolic process GO:0006688 glycosphingolipid biosynthetic process GO:0008544 epidermis development
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