Human Gene LHX2 (ENST00000373615.9) from GENCODE V44
Description: Homo sapiens LIM homeobox 2 (LHX2), mRNA. (from RefSeq NM_004789) RefSeq Summary (NM_004789): This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000373615.9 Gencode Gene: ENSG00000106689.11 Transcript (Including UTRs) Position: hg38 chr9:124,011,768-124,033,301 Size: 21,534 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr9:124,012,349-124,032,707 Size: 20,359 Coding Exon Count: 5
ID:LHX2_HUMAN DESCRIPTION: RecName: Full=LIM/homeobox protein Lhx2; Short=Homeobox protein LH-2; Short=LIM homeobox protein 2; FUNCTION: Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity). SUBUNIT: interacts (via LIM domains) with CITED2 (By similarity). SUBCELLULAR LOCATION: Nucleus (Probable). DOMAIN: LIM domains are necessary for transcription activation (By similarity). SIMILARITY: Contains 1 homeobox DNA-binding domain. SIMILARITY: Contains 2 LIM zinc-binding domains. SEQUENCE CAUTION: Sequence=BAC04371.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P50458
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0001843 neural tube closure GO:0001942 hair follicle development GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007399 nervous system development GO:0007411 axon guidance GO:0007420 brain development GO:0007498 mesoderm development GO:0009953 dorsal/ventral pattern formation GO:0021537 telencephalon development GO:0021772 olfactory bulb development GO:0021978 telencephalon regionalization GO:0021987 cerebral cortex development GO:0022008 neurogenesis GO:0030182 neuron differentiation GO:0045199 maintenance of epithelial cell apical/basal polarity GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048646 anatomical structure formation involved in morphogenesis GO:0048675 axon extension GO:0060041 retina development in camera-type eye GO:2000678 negative regulation of transcription regulatory region DNA binding