Human Gene NUP188 (ENST00000372577.2) from GENCODE V43
  Description: Homo sapiens nucleoporin 188 (NUP188), mRNA. (from RefSeq NM_015354)
RefSeq Summary (NM_015354): The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. The NPC is comprised of approximately 30 distinct proteins collectively known as nucleoporins. Nucleoporins are pore-complex-specific glycoproteins which often have cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. However, the nucleoporin protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. This nucleoporin is thought to form part of the scaffold for the central channel of the nuclear pore. [provided by RefSeq, Jan 2013].
Gencode Transcript: ENST00000372577.2
Gencode Gene: ENSG00000095319.14
Transcript (Including UTRs)
   Position: hg38 chr9:128,947,699-129,007,096 Size: 59,398 Total Exon Count: 44 Strand: +
Coding Region
   Position: hg38 chr9:128,947,720-129,006,678 Size: 58,959 Coding Exon Count: 44 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-02-17 13:02:02

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr9:128,947,699-129,007,096)mRNA (may differ from genome)Protein (1749 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGencode

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Nucleoporin NUP188 homolog; Short=hNup188;
FUNCTION: May function as a component of the nuclear pore complex (NPC).
SUBCELLULAR LOCATION: Nucleus, nuclear pore complex (Probable).
SEQUENCE CAUTION: Sequence=CAD97835.1; Type=Erroneous initiation;

-  Primer design for this transcript

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Click here to load the transcript sequence and exon structure into Primer3Plus

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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  MalaCards Disease Associations
  MalaCards Gene Search: NUP188
Diseases sorted by gene-association score: heart disease (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 51.64 RPKM in Testis
Total median expression: 474.73 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.3021-0.252 Picture PostScript Text
3' UTR -145.90418-0.349 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018864 - Nucleoporin_Nup188

Pfam Domains:
PF10487 - Nucleoporin subcomplex protein binding to Pom34

ModBase Predicted Comparative 3D Structure on Q5SRE5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein SequenceProtein SequenceProtein Sequence  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0017056 structural constituent of nuclear pore

Biological Process:
GO:0006405 RNA export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006606 protein import into nucleus
GO:0015031 protein transport
GO:0016032 viral process
GO:0051028 mRNA transport
GO:0090521 glomerular visceral epithelial cell migration

Cellular Component:
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0016020 membrane
GO:0044611 nuclear pore inner ring

-  Descriptions from all associated GenBank mRNAs
  LF383686 - JP 2014500723-A/191189: Polycomb-Associated Non-Coding RNAs.
MA619263 - JP 2018138019-A/191189: Polycomb-Associated Non-Coding RNAs.
BX537774 - Homo sapiens mRNA; cDNA DKFZp686L1653 (from clone DKFZp686L1653).
BC160096 - Synthetic construct Homo sapiens clone IMAGE:100064128, MGC:193211 nucleoporin 188kDa (NUP188) mRNA, encodes complete protein.
D79991 - Homo sapiens mRNA for KIAA0169 protein, partial cds.
DQ656056 - Homo sapiens clone UGL012-A-B2, mRNA sequence.
LF346651 - JP 2014500723-A/154154: Polycomb-Associated Non-Coding RNAs.
MA582228 - JP 2018138019-A/154154: Polycomb-Associated Non-Coding RNAs.
DQ656057 - Homo sapiens clone UGL012-A-C2, mRNA sequence.
LF346653 - JP 2014500723-A/154156: Polycomb-Associated Non-Coding RNAs.
MA582230 - JP 2018138019-A/154156: Polycomb-Associated Non-Coding RNAs.
LF346656 - JP 2014500723-A/154159: Polycomb-Associated Non-Coding RNAs.
MA582233 - JP 2018138019-A/154159: Polycomb-Associated Non-Coding RNAs.
LF346657 - JP 2014500723-A/154160: Polycomb-Associated Non-Coding RNAs.
MA582234 - JP 2018138019-A/154160: Polycomb-Associated Non-Coding RNAs.
LF346658 - JP 2014500723-A/154161: Polycomb-Associated Non-Coding RNAs.
MA582235 - JP 2018138019-A/154161: Polycomb-Associated Non-Coding RNAs.
LF346659 - JP 2014500723-A/154162: Polycomb-Associated Non-Coding RNAs.
MA582236 - JP 2018138019-A/154162: Polycomb-Associated Non-Coding RNAs.
LF346660 - JP 2014500723-A/154163: Polycomb-Associated Non-Coding RNAs.
MA582237 - JP 2018138019-A/154163: Polycomb-Associated Non-Coding RNAs.
LF346661 - JP 2014500723-A/154164: Polycomb-Associated Non-Coding RNAs.
MA582238 - JP 2018138019-A/154164: Polycomb-Associated Non-Coding RNAs.
LF346662 - JP 2014500723-A/154165: Polycomb-Associated Non-Coding RNAs.
MA582239 - JP 2018138019-A/154165: Polycomb-Associated Non-Coding RNAs.
BC040352 - Homo sapiens nucleoporin 188kDa, mRNA (cDNA clone IMAGE:3861295), partial cds.
BC005407 - Homo sapiens nucleoporin 188kDa, mRNA (cDNA clone IMAGE:3461492), partial cds.
BC111045 - Homo sapiens nucleoporin 188kDa, mRNA (cDNA clone IMAGE:5518173), partial cds.
LF346665 - JP 2014500723-A/154168: Polycomb-Associated Non-Coding RNAs.
MA582242 - JP 2018138019-A/154168: Polycomb-Associated Non-Coding RNAs.
LF346666 - JP 2014500723-A/154169: Polycomb-Associated Non-Coding RNAs.
MA582243 - JP 2018138019-A/154169: Polycomb-Associated Non-Coding RNAs.
AK025292 - Homo sapiens cDNA: FLJ21639 fis, clone COL08276.
JD024810 - Sequence 5834 from Patent EP1572962.
LF346668 - JP 2014500723-A/154171: Polycomb-Associated Non-Coding RNAs.
MA582245 - JP 2018138019-A/154171: Polycomb-Associated Non-Coding RNAs.
LF346669 - JP 2014500723-A/154172: Polycomb-Associated Non-Coding RNAs.
MA582246 - JP 2018138019-A/154172: Polycomb-Associated Non-Coding RNAs.
JD520546 - Sequence 501570 from Patent EP1572962.
JD104956 - Sequence 85980 from Patent EP1572962.
JD069475 - Sequence 50499 from Patent EP1572962.
JD459427 - Sequence 440451 from Patent EP1572962.
JD401352 - Sequence 382376 from Patent EP1572962.
JD158628 - Sequence 139652 from Patent EP1572962.
JD416410 - Sequence 397434 from Patent EP1572962.
JD100218 - Sequence 81242 from Patent EP1572962.
JD530178 - Sequence 511202 from Patent EP1572962.
JD389403 - Sequence 370427 from Patent EP1572962.
JD383258 - Sequence 364282 from Patent EP1572962.
JD187104 - Sequence 168128 from Patent EP1572962.
JD335231 - Sequence 316255 from Patent EP1572962.
JD360567 - Sequence 341591 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q5SRE5 (Reactome details) participates in the following event(s):

R-HSA-75096 Docking of the TAP:EJC Complex with the NPC
R-HSA-165043 Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC
R-HSA-180622 Vpr binds nucleoporins
R-HSA-180710 Rev:importin beta:B23 recruited to the nuclear pore
R-HSA-2990882 CDK1 phosphorylates NUP98
R-HSA-75098 mRNP complex dissociates from cytosolic face of NPC
R-HSA-165047 Translocation of nuclear RNA transport complex to cytoplasm
R-HSA-180732 Translocation of Rev:importin-beta:B23 to the nucleus
R-HSA-2990880 NEK6/NEK7 phosphorylates NUP98
R-HSA-170796 NPC transports GCK1:GKRP from cytosol to nucleoplasm
R-HSA-5578744 Importin-8 imports AGO2:miRNA into the nucleus
R-HSA-6783483 tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol
R-HSA-3000348 RANBP2 SUMOylates SP100 with SUMO2
R-HSA-3000399 RANBP2 SUMOylates SP100 with SUMO1
R-HSA-3000411 RANBP2 SUMOylates PML with SUMO2
R-HSA-4570493 RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1
R-HSA-4615872 RANBP2 SUMOylates HDAC4 with SUMO1
R-HSA-4615987 RANBP2 SUMOylates HDAC4 with SUMO2,3
R-HSA-5228508 RANBP2 SUMOylates PML with SUMO1
R-HSA-5228525 RANBP2 SUMOylates TOP2A with SUMO1
R-HSA-192627 Viral mRNA Export
R-HSA-192925 Export of Spliced Viral mRNA
R-HSA-5252041 NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-180746 Nuclear import of Rev protein
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-72202 Transport of Mature Transcript to Cytoplasm
R-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-177243 Interactions of Rev with host cellular proteins
R-HSA-176033 Interactions of Vpr with host cellular proteins
R-HSA-2980766 Nuclear Envelope Breakdown
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-162587 HIV Life Cycle
R-HSA-162909 Host Interactions of HIV factors
R-HSA-68875 Mitotic Prophase
R-HSA-70171 Glycolysis
R-HSA-168253 Host Interactions with Influenza Factors
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
R-HSA-211000 Gene Silencing by RNA
R-HSA-72306 tRNA processing
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-168273 Influenza Viral RNA Transcription and Replication
R-HSA-3371556 Cellular response to heat stress
R-HSA-8953854 Metabolism of RNA
R-HSA-162906 HIV Infection
R-HSA-68886 M Phase
R-HSA-70326 Glucose metabolism
R-HSA-168254 Influenza Infection
R-HSA-913531 Interferon Signaling
R-HSA-74160 Gene expression (Transcription)
R-HSA-2990846 SUMOylation
R-HSA-168255 Influenza Life Cycle
R-HSA-2262752 Cellular responses to stress
R-HSA-5663205 Infectious disease
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-71387 Metabolism of carbohydrates
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-597592 Post-translational protein modification
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-1643685 Disease
R-HSA-1640170 Cell Cycle
R-HSA-1430728 Metabolism
R-HSA-168256 Immune System
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000372577.1, KIAA0169, NM_015354, NU188_HUMAN, Q14675, Q2TA87, Q5SRE5, Q7Z3K8, Q8IWF1, uc004bws.1, uc004bws.2, uc004bws.3
UCSC ID: ENST00000372577.2
RefSeq Accession: NM_015354
Protein: Q5SRE5 (aka NU188_HUMAN)
CCDS: CCDS35156.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.