Description: Homo sapiens nucleoporin 188 (NUP188), mRNA. (from RefSeq NM_015354) RefSeq Summary (NM_015354): The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. The NPC is comprised of approximately 30 distinct proteins collectively known as nucleoporins. Nucleoporins are pore-complex-specific glycoproteins which often have cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. However, the nucleoporin protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. This nucleoporin is thought to form part of the scaffold for the central channel of the nuclear pore. [provided by RefSeq, Jan 2013]. Gencode Transcript: ENST00000372577.2 Gencode Gene: ENSG00000095319.14 Transcript (Including UTRs) Position: hg38 chr9:128,947,699-129,007,096 Size: 59,398 Total Exon Count: 44 Strand: + Coding Region Position: hg38 chr9:128,947,720-129,006,678 Size: 58,959 Coding Exon Count: 44
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF10487 - Nucleoporin subcomplex protein binding to Pom34
ModBase Predicted Comparative 3D Structure on Q5SRE5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.