Human Gene PTPA (ENST00000358994.9) from GENCODE V44
  Description: protein phosphatase 2 phosphatase activator (from HGNC PTPA)
RefSeq Summary (NM_021131): Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000358994.9
Gencode Gene: ENSG00000119383.21
Transcript (Including UTRs)
   Position: hg38 chr9:129,110,950-129,148,944 Size: 37,995 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg38 chr9:129,111,012-129,147,464 Size: 36,453 Coding Exon Count: 11 

Page IndexSequence and LinksPrimersMalaCardsRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:129,110,950-129,148,944)mRNA (may differ from genome)Protein (373 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblExonPrimerGencodeGeneCardsMalacardsMGI
PubMedUniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PTPA
Diseases sorted by gene-association score: apical myocardial infarction (2), leukemia, acute myeloid (2), breast cancer (2), hypersomnia (2), spinocerebellar ataxia 12 (2), hereditary wilms' tumor (1)

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 58.01 RPKM in Testis
Total median expression: 1195.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.4062-0.313 Picture PostScript Text
3' UTR -692.901480-0.468 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
MGIRGDEnsemblEnsembl SGD
Protein SequenceProtein SequenceProtein SequenceProtein Sequence Protein Sequence
AlignmentAlignmentAlignmentAlignment Alignment

-  Descriptions from all associated GenBank mRNAs
  BC002545 - Homo sapiens protein phosphatase 2A activator, regulatory subunit 4, mRNA (cDNA clone MGC:2184 IMAGE:3138990), complete cds.
BC011605 - Homo sapiens protein phosphatase 2A activator, regulatory subunit 4, mRNA (cDNA clone MGC:2970 IMAGE:3140067), complete cds.
JD518253 - Sequence 499277 from Patent EP1572962.
AK302043 - Homo sapiens cDNA FLJ54096 complete cds, highly similar to Serine/threonine-protein phosphatase 2A regulatory subunit B'.
AK302897 - Homo sapiens cDNA FLJ54705 complete cds, highly similar to Serine/threonine-protein phosphatase 2A regulatory subunit B'.
CR749810 - Homo sapiens mRNA; cDNA DKFZp781M17165 (from clone DKFZp781M17165).
X73478 - H.sapiens hPTPA mRNA.
AK222788 - Homo sapiens mRNA for regulatory subunit PR 53 of protein phosphatase 2A isoform b variant, clone: HEP01495.
JD458947 - Sequence 439971 from Patent EP1572962.
JD073829 - Sequence 54853 from Patent EP1572962.
JD460456 - Sequence 441480 from Patent EP1572962.
JD395871 - Sequence 376895 from Patent EP1572962.
DQ575854 - Homo sapiens piRNA piR-43966, complete sequence.
AK297202 - Homo sapiens cDNA FLJ60126 complete cds, highly similar to Homo sapiens protein phosphatase 2A, regulatory subunit B', transcript variant 5, mRNA.
CU678032 - Synthetic construct Homo sapiens gateway clone IMAGE:100018924 5' read PPP2R4 mRNA.
AB464103 - Synthetic construct DNA, clone: pF1KB6503, Homo sapiens PPP2R4 gene for protein phosphatase 2A activator, regulatory subunit 4, without stop codon, in Flexi system.
KJ891871 - Synthetic construct Homo sapiens clone ccsbBroadEn_01265 PPP2R4 gene, encodes complete protein.
BT020119 - Homo sapiens protein phosphatase 2A, regulatory subunit B' (PR 53) mRNA, complete cds.
DQ892154 - Synthetic construct clone IMAGE:100004784; FLH183516.01X; RZPDo839D06142D protein phosphatase 2A, regulatory subunit B' (PR 53) (PPP2R4) gene, encodes complete protein.
DQ894879 - Synthetic construct Homo sapiens clone IMAGE:100009339; FLH263680.01L; RZPDo839C05141D protein phosphatase 2A, regulatory subunit B' (PR 53) (PPP2R4) gene, encodes complete protein.
DQ895349 - Synthetic construct Homo sapiens clone IMAGE:100009809; FLH183512.01L; RZPDo839D06141D protein phosphatase 2A, regulatory subunit B' (PR 53) (PPP2R4) gene, encodes complete protein.
AK307424 - Homo sapiens cDNA, FLJ97372.
DQ582223 - Homo sapiens piRNA piR-32335, complete sequence.
DQ600004 - Homo sapiens piRNA piR-38070, complete sequence.
DQ593084 - Homo sapiens piRNA piR-33196, complete sequence.
JD120113 - Sequence 101137 from Patent EP1572962.
DQ586830 - Homo sapiens piRNA piR-53942, complete sequence.
JD470140 - Sequence 451164 from Patent EP1572962.
JD374256 - Sequence 355280 from Patent EP1572962.
JD470366 - Sequence 451390 from Patent EP1572962.
JD313179 - Sequence 294203 from Patent EP1572962.
JD239746 - Sequence 220770 from Patent EP1572962.
JD054190 - Sequence 35214 from Patent EP1572962.
JD130014 - Sequence 111038 from Patent EP1572962.
JD533040 - Sequence 514064 from Patent EP1572962.
JD140876 - Sequence 121900 from Patent EP1572962.
DQ587061 - Homo sapiens piRNA piR-54173, complete sequence.
AK293296 - Homo sapiens cDNA FLJ52532 complete cds, weakly similar to Serine/threonine-protein phosphatase 2A regulatory subunit B'.
AK310328 - Homo sapiens cDNA, FLJ17370.
AK310543 - Homo sapiens cDNA, FLJ17585.
BC020581 - Homo sapiens protein phosphatase 2A activator, regulatory subunit 4, mRNA (cDNA clone IMAGE:4392956), with apparent retained intron.
DQ574010 - Homo sapiens piRNA piR-42122, complete sequence.
DQ585074 - Homo sapiens piRNA piR-52186, complete sequence.
BC010497 - Homo sapiens, clone IMAGE:3447497, mRNA.
JD500460 - Sequence 481484 from Patent EP1572962.
JD497308 - Sequence 478332 from Patent EP1572962.
JD210443 - Sequence 191467 from Patent EP1572962.
JD064913 - Sequence 45937 from Patent EP1572962.
DQ577790 - Homo sapiens piRNA piR-45902, complete sequence.
JD526799 - Sequence 507823 from Patent EP1572962.
JD477227 - Sequence 458251 from Patent EP1572962.
JD518798 - Sequence 499822 from Patent EP1572962.
JD480810 - Sequence 461834 from Patent EP1572962.
JD128500 - Sequence 109524 from Patent EP1572962.
JD251758 - Sequence 232782 from Patent EP1572962.
JD180678 - Sequence 161702 from Patent EP1572962.
JD403833 - Sequence 384857 from Patent EP1572962.
JD223236 - Sequence 204260 from Patent EP1572962.
JD498854 - Sequence 479878 from Patent EP1572962.
JD223294 - Sequence 204318 from Patent EP1572962.
JD464874 - Sequence 445898 from Patent EP1572962.
JD287340 - Sequence 268364 from Patent EP1572962.
JD546921 - Sequence 527945 from Patent EP1572962.
JD163045 - Sequence 144069 from Patent EP1572962.
JD069130 - Sequence 50154 from Patent EP1572962.
JD424231 - Sequence 405255 from Patent EP1572962.
JD218823 - Sequence 199847 from Patent EP1572962.
JD075230 - Sequence 56254 from Patent EP1572962.
JD484269 - Sequence 465293 from Patent EP1572962.
JD538067 - Sequence 519091 from Patent EP1572962.
JD402076 - Sequence 383100 from Patent EP1572962.
JD475818 - Sequence 456842 from Patent EP1572962.
JD192753 - Sequence 173777 from Patent EP1572962.
JD400285 - Sequence 381309 from Patent EP1572962.
JD021738 - Sequence 2762 from Patent EP1572962.
JD027622 - Sequence 8646 from Patent EP1572962.
JD456779 - Sequence 437803 from Patent EP1572962.
JD398087 - Sequence 379111 from Patent EP1572962.
JD563758 - Sequence 544782 from Patent EP1572962.
JD415143 - Sequence 396167 from Patent EP1572962.
JD202264 - Sequence 183288 from Patent EP1572962.
JD063353 - Sequence 44377 from Patent EP1572962.
JD485165 - Sequence 466189 from Patent EP1572962.
JD218596 - Sequence 199620 from Patent EP1572962.
JD479085 - Sequence 460109 from Patent EP1572962.
JD193907 - Sequence 174931 from Patent EP1572962.
JD394105 - Sequence 375129 from Patent EP1572962.
JD427764 - Sequence 408788 from Patent EP1572962.
JD493205 - Sequence 474229 from Patent EP1572962.
JD436641 - Sequence 417665 from Patent EP1572962.
JD105810 - Sequence 86834 from Patent EP1572962.
JD415622 - Sequence 396646 from Patent EP1572962.
JD369634 - Sequence 350658 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_srcRPTPPathway - Activation of Src by Protein-tyrosine phosphatase alpha

-  Other Names for This Gene
  Alternate Gene Symbols: A0A804CD06, BC002545, ENST00000358994.1, ENST00000358994.2, ENST00000358994.3, ENST00000358994.4, ENST00000358994.5, ENST00000358994.6, ENST00000358994.7, ENST00000358994.8, uc004bxl.1, uc004bxl.2, uc004bxl.3, uc004bxl.4
UCSC ID: ENST00000358994.9
RefSeq Accession: NM_021131

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.