Human Gene OLFM1 (ENST00000252854.8) from GENCODE V44
  Description: Homo sapiens olfactomedin 1 (OLFM1), transcript variant 1, mRNA. (from RefSeq NM_014279)
RefSeq Summary (NM_014279): This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000252854.8
Gencode Gene: ENSG00000130558.20
Transcript (Including UTRs)
   Position: hg38 chr9:135,075,520-135,121,178 Size: 45,659 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr9:135,075,707-135,120,178 Size: 44,472 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr9:135,075,520-135,121,178)mRNA (may differ from genome)Protein (467 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Noelin; AltName: Full=Neuronal olfactomedin-related ER localized protein; AltName: Full=Olfactomedin-1; Flags: Precursor;
FUNCTION: Seems to play an important role in regulating the production of neural crest cells by the neural tube (By similarity).
INTERACTION: Q9NRI5:DISC1; NbExp=3; IntAct=EBI-1105073, EBI-529989;
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen (Potential).
SIMILARITY: Contains 1 olfactomedin-like domain.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  MalaCards Disease Associations
  MalaCards Gene Search: OLFM1
Diseases sorted by gene-association score: neuroblastoma (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D003993 Dibutyl Phthalate
  • D004997 Ethinyl Estradiol
  • D011374 Progesterone
  • D015058 1-Naphthylisothiocyanate
  • C495626 14-deoxy-11,12-didehydroandrographolide
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone
  • C023514 2,6-dinitrotoluene
  • C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester
  • D015073 2-Acetylaminofluorene
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 178.81 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 1148.15 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -90.80187-0.486 Picture PostScript Text
3' UTR -291.401000-0.291 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022082 - Noelin-1
IPR003112 - Olfac-like
IPR011047 - Quinonprotein_ADH-like

Pfam Domains:
PF12308 - Neurogenesis glycoprotein
PF02191 - Olfactomedin-like domain

ModBase Predicted Comparative 3D Structure on Q99784
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0003190 atrioventricular valve formation
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0023041 neuronal signal transduction
GO:0030516 regulation of axon extension
GO:0060317 cardiac epithelial to mesenchymal transition

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005623 cell
GO:0005783 endoplasmic reticulum
GO:0030054 cell junction
GO:0030424 axon
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0044295 axonal growth cone
GO:0045202 synapse

-  Descriptions from all associated GenBank mRNAs
  D82343 - Homo sapiens mRNA for AMY, complete cds.
BC000189 - Homo sapiens olfactomedin 1, mRNA (cDNA clone IMAGE:3351052), complete cds.
BC008763 - Homo sapiens olfactomedin 1, mRNA (cDNA clone MGC:1341 IMAGE:3349741), complete cds.
BC011741 - Homo sapiens olfactomedin 1, mRNA (cDNA clone MGC:19671 IMAGE:3352603), complete cds.
JD406604 - Sequence 387628 from Patent EP1572962.
JD139319 - Sequence 120343 from Patent EP1572962.
AK289719 - Homo sapiens cDNA FLJ78726 complete cds, highly similar to Homo sapiens olfactomedin 1 (OLFM1), transcript variant 1, mRNA.
JD190380 - Sequence 171404 from Patent EP1572962.
JD190381 - Sequence 171405 from Patent EP1572962.
AK289921 - Homo sapiens cDNA FLJ76343 complete cds, highly similar to Homo sapiens olfactomedin 1 (OLFM1), transcript variant 1, mRNA.
JD493263 - Sequence 474287 from Patent EP1572962.
JD451787 - Sequence 432811 from Patent EP1572962.
JD156600 - Sequence 137624 from Patent EP1572962.
CU679089 - Synthetic construct Homo sapiens gateway clone IMAGE:100020280 5' read OLFM1 mRNA.
JF432290 - Synthetic construct Homo sapiens clone IMAGE:100073467 olfactomedin 1 (OLFM1) gene, encodes complete protein.
KJ898214 - Synthetic construct Homo sapiens clone ccsbBroadEn_07608 OLFM1 gene, encodes complete protein.
BT007146 - Homo sapiens olfactomedin 1 mRNA, complete cds.
AK096304 - Homo sapiens cDNA FLJ38985 fis, clone NT2RI2005670, highly similar to NEURONAL OLFACTOMEDIN-RELATED ER LOCALIZED PROTEIN PRECURSOR.
AK290478 - Homo sapiens cDNA FLJ75446 complete cds.
BC015437 - Homo sapiens olfactomedin 1, mRNA (cDNA clone IMAGE:4421241), partial cds.
AK090818 - Homo sapiens cDNA FLJ33499 fis, clone BRAMY2004351, highly similar to Noelin precursor.
U79299 - Human neuronal olfactomedin-related ER localized protein mRNA, partial cds.
AF035301 - Homo sapiens clone 23876 neuronal olfactomedin-related ER localized protein mRNA, partial cds.
JD056881 - Sequence 37905 from Patent EP1572962.
JD361064 - Sequence 342088 from Patent EP1572962.
JD462392 - Sequence 443416 from Patent EP1572962.
JD355501 - Sequence 336525 from Patent EP1572962.
JD396437 - Sequence 377461 from Patent EP1572962.
JD424745 - Sequence 405769 from Patent EP1572962.
JD501402 - Sequence 482426 from Patent EP1572962.
JD178885 - Sequence 159909 from Patent EP1572962.
JD257815 - Sequence 238839 from Patent EP1572962.
JD492448 - Sequence 473472 from Patent EP1572962.
JD233554 - Sequence 214578 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000252854.1, ENST00000252854.2, ENST00000252854.3, ENST00000252854.4, ENST00000252854.5, ENST00000252854.6, ENST00000252854.7, NM_014279, NOE1, NOE1_HUMAN, NOEL1, Q53XZ8, Q6IMJ4, Q969S7, Q99452, Q99784, uc004cfl.1, uc004cfl.2, uc004cfl.3, uc004cfl.4, uc004cfl.5
UCSC ID: ENST00000252854.8
RefSeq Accession: NM_014279
Protein: Q99784 (aka NOE1_HUMAN)
CCDS: CCDS6986.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.