Human Gene OLFM1 (ENST00000252854.8) from GENCODE V44
Description: Homo sapiens olfactomedin 1 (OLFM1), transcript variant 1, mRNA. (from RefSeq NM_014279) RefSeq Summary (NM_014279): This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000252854.8 Gencode Gene: ENSG00000130558.20 Transcript (Including UTRs) Position: hg38 chr9:135,075,520-135,121,178 Size: 45,659 Total Exon Count: 6 Strand: + Coding Region Position: hg38 chr9:135,075,707-135,120,178 Size: 44,472 Coding Exon Count: 6
ID:NOE1_HUMAN DESCRIPTION: RecName: Full=Noelin; AltName: Full=Neuronal olfactomedin-related ER localized protein; AltName: Full=Olfactomedin-1; Flags: Precursor; FUNCTION: Seems to play an important role in regulating the production of neural crest cells by the neural tube (By similarity). INTERACTION: Q9NRI5:DISC1; NbExp=3; IntAct=EBI-1105073, EBI-529989; SUBCELLULAR LOCATION: Endoplasmic reticulum lumen (Potential). SIMILARITY: Contains 1 olfactomedin-like domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99784
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0003190 atrioventricular valve formation GO:0007275 multicellular organism development GO:0007399 nervous system development GO:0010628 positive regulation of gene expression GO:0010629 negative regulation of gene expression GO:0010718 positive regulation of epithelial to mesenchymal transition GO:0023041 neuronal signal transduction GO:0030516 regulation of axon extension GO:0060317 cardiac epithelial to mesenchymal transition