Human Gene PRPS2 (ENST00000380668.10) from GENCODE V44
Description: Homo sapiens phosphoribosyl pyrophosphate synthetase 2 (PRPS2), transcript variant 2, mRNA. (from RefSeq NM_002765) RefSeq Summary (NM_002765): This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]. Gencode Transcript: ENST00000380668.10 Gencode Gene: ENSG00000101911.13 Transcript (Including UTRs) Position: hg38 chrX:12,791,412-12,824,222 Size: 32,811 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chrX:12,791,498-12,822,796 Size: 31,299 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P11908
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process GO:0006139 nucleobase-containing compound metabolic process GO:0006167 AMP biosynthetic process GO:0009116 nucleoside metabolic process GO:0009156 ribonucleoside monophosphate biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0016310 phosphorylation GO:0019693 ribose phosphate metabolic process GO:0031100 animal organ regeneration GO:0044249 cellular biosynthetic process