Human Gene PLP2 (ENST00000376327.6) from GENCODE V44
Description: Homo sapiens proteolipid protein 2 (PLP2), mRNA. (from RefSeq NM_002668) RefSeq Summary (NM_002668): This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked cognitive disability. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000376327.6 Gencode Gene: ENSG00000102007.11 Transcript (Including UTRs) Position: hg38 chrX:49,171,898-49,175,235 Size: 3,338 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chrX:49,172,001-49,174,694 Size: 2,694 Coding Exon Count: 5
ID:PLP2_HUMAN DESCRIPTION: RecName: Full=Proteolipid protein 2; AltName: Full=Differentiation-dependent protein A4; AltName: Full=Intestinal membrane A4 protein; FUNCTION: May play a role in cell differentiation in the intestinal epithelium. INTERACTION: P32246:CCR1; NbExp=3; IntAct=EBI-608347, EBI-608322; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Enriched in colonic mucosa. The expression of A4 follows a gradient along the crypto-villus axis with the most abundant message occurring in the lower half of the crypt. SIMILARITY: Contains 1 MARVEL domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q04941
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.