Human Gene DACH2 (ENST00000373125.9) from GENCODE V44
Description: Homo sapiens dachshund family transcription factor 2 (DACH2), transcript variant 1, mRNA. (from RefSeq NM_053281) RefSeq Summary (NM_053281): This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]. Gencode Transcript: ENST00000373125.9 Gencode Gene: ENSG00000126733.22 Transcript (Including UTRs) Position: hg38 chrX:86,148,451-86,832,602 Size: 684,152 Total Exon Count: 12 Strand: + Coding Region Position: hg38 chrX:86,148,621-86,832,155 Size: 683,535 Coding Exon Count: 12
ID:DACH2_HUMAN DESCRIPTION: RecName: Full=Dachshund homolog 2; Short=Dach2; FUNCTION: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain. SUBUNIT: Interacts with SIX6 and EYA2 (By similarity). SUBCELLULAR LOCATION: Nucleus (Probable). DOMAIN: The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain (By similarity). SIMILARITY: Belongs to the DACH/dachshund family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96NX9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly GO:0003677 DNA binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0046545 development of primary female sexual characteristics GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly
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