Human Gene NDUFA1 (ENST00000371437.5) from GENCODE V44
Description: Homo sapiens NADH:ubiquinone oxidoreductase subunit A1 (NDUFA1), mRNA. (from RefSeq NM_004541) RefSeq Summary (NM_004541): The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the 'hydrophobic protein' (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000371437.5 Gencode Gene: ENSG00000125356.7 Transcript (Including UTRs) Position: hg38 chrX:119,871,832-119,876,662 Size: 4,831 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chrX:119,871,912-119,876,534 Size: 4,623 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6IBB5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
