Human Gene MUTYH (ENST00000450313.6) from GENCODE V44
Description: mutY DNA glycosylase (from HGNC MUTYH) RefSeq Summary (NM_001128425): This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]. Gencode Transcript: ENST00000450313.6 Gencode Gene: ENSG00000132781.21 Transcript (Including UTRs) Position: hg38 chr1:45,332,196-45,340,399 Size: 8,204 Total Exon Count: 9 Strand: -
Press "+" in the title bar above to open this section.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
LF206566 - JP 2014500723-A/14069: Polycomb-Associated Non-Coding RNAs. MA442143 - JP 2018138019-A/14069: Polycomb-Associated Non-Coding RNAs. AK293830 - Homo sapiens cDNA FLJ53724 complete cds, highly similar to A/G-specific adenine DNA glycosylase (EC 3.2.2.-). AB032924 - Homo sapiens mRNA for hMYHbeta1, complete cds. AB032925 - Homo sapiens mRNA for hMYHbeta3, complete cds. AB032926 - Homo sapiens mRNA for hMYHbeta5, complete cds. AB032927 - Homo sapiens mRNA for hMYHgamma2, complete cds. AB032928 - Homo sapiens mRNA for hMYHgamma3, complete cds. AB032929 - Homo sapiens mRNA for hMYHgamma4, complete cds. AB032920 - Homo sapiens mRNA for hMYHalpha1, complete cds. AB032921 - Homo sapiens mRNA for hMYHalpha2, complete cds. AB032922 - Homo sapiens mRNA for hMYHalpha3, complete cds. AB032923 - Homo sapiens mRNA for hMYHalpha4, complete cds. BC003178 - Homo sapiens mutY homolog (E. coli), mRNA (cDNA clone MGC:4416 IMAGE:2958002), complete cds. KU178203 - Homo sapiens mutY-like protein isoform 1 (MUTYH) mRNA, partial cds. KU178204 - Homo sapiens mutY-like protein isoform 3 (MUTYH) mRNA, complete cds, alternatively spliced. AB590565 - Synthetic construct DNA, clone: pFN21AE1976, Homo sapiens MUTYH gene for mutY homolog, without stop codon, in Flexi system. CU678424 - Synthetic construct Homo sapiens gateway clone IMAGE:100020334 5' read MUTYH mRNA. AB025227 - Homo sapiens mRNA for MutY homolog (hMYH), partial cds. JD258625 - Sequence 239649 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03410 - Base excision repair