Human Gene NKX2-3 (ENST00000344586.9) from GENCODE V44
Description: Homo sapiens NK2 homeobox 3 (NKX2-3), mRNA. (from RefSeq NM_145285) RefSeq Summary (NM_145285): This gene encodes a homeodomain-containing transcription factor. The encoded protein is a member of the NKX family of homeodomain transcription factors. Studies of similar proteins in mouse and rat have indicated a potential role in cellular differentiation.[provided by RefSeq, Mar 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by orthologous data and transcript alignments. Gencode Transcript: ENST00000344586.9 Gencode Gene: ENSG00000119919.12 Transcript (Including UTRs) Position: hg38 chr10:99,532,942-99,536,524 Size: 3,583 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr10:99,533,132-99,535,721 Size: 2,590 Coding Exon Count: 2
ID:NKX23_HUMAN DESCRIPTION: RecName: Full=Homeobox protein Nkx-2.3; AltName: Full=Homeobox protein NK-2 homolog C; FUNCTION: Transcription factor (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). SIMILARITY: Belongs to the NK-2 homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain. SEQUENCE CAUTION: Sequence=AAH25788.1; Type=Frameshift; Positions=273; Note=This frameshift is potential, but if it is real then the sequence of residues 274-302 are lacking from the translated cDNA while this region does not seem to correspond to an exon;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TAU0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.