Human Gene LPAR5 (ENST00000431922.1) from GENCODE V44
  Description: Homo sapiens lysophosphatidic acid receptor 5 (LPAR5), transcript variant 2, mRNA. (from RefSeq NM_001142961)
RefSeq Summary (NM_001142961): This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008].
Gencode Transcript: ENST00000431922.1
Gencode Gene: ENSG00000184574.10
Transcript (Including UTRs)
   Position: hg38 chr12:6,618,835-6,631,649 Size: 12,815 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr12:6,620,130-6,621,248 Size: 1,119 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:6,618,835-6,631,649)mRNA (may differ from genome)Protein (372 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMGIneXtProtOMIMPubMed
ReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LPAR5_HUMAN
DESCRIPTION: RecName: Full=Lysophosphatidic acid receptor 5; Short=LPA receptor 5; Short=LPA-5; AltName: Full=G-protein coupled receptor 92; AltName: Full=G-protein coupled receptor 93;
FUNCTION: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Not expressed in frontal cortex, basal forebrain, caudate putamen, thalamus, or hippocampus.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.96 RPKM in Esophagus - Mucosa
Total median expression: 93.47 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -87.50281-0.311 Picture PostScript Text
3' UTR -362.601295-0.280 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR002286 - P2_purnocptor

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on Q9H1C0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC072394 - Homo sapiens lysophosphatidic acid receptor 5, mRNA (cDNA clone MGC:87779 IMAGE:5751923), complete cds.
BC033571 - Homo sapiens lysophosphatidic acid receptor 5, mRNA (cDNA clone MGC:12926 IMAGE:4297800), complete cds.
JD060880 - Sequence 41904 from Patent EP1572962.
JD185694 - Sequence 166718 from Patent EP1572962.
JD094886 - Sequence 75910 from Patent EP1572962.
JD200870 - Sequence 181894 from Patent EP1572962.
JD420686 - Sequence 401710 from Patent EP1572962.
JD537505 - Sequence 518529 from Patent EP1572962.
AK302786 - Homo sapiens cDNA FLJ51160 complete cds, highly similar to Probable G-protein coupled receptor 92.
JD354371 - Sequence 335395 from Patent EP1572962.
JD310662 - Sequence 291686 from Patent EP1572962.
JD477265 - Sequence 458289 from Patent EP1572962.
JD189186 - Sequence 170210 from Patent EP1572962.
JD223007 - Sequence 204031 from Patent EP1572962.
JD452252 - Sequence 433276 from Patent EP1572962.
JD094183 - Sequence 75207 from Patent EP1572962.
JD504284 - Sequence 485308 from Patent EP1572962.
JD545040 - Sequence 526064 from Patent EP1572962.
JD170737 - Sequence 151761 from Patent EP1572962.
JD224139 - Sequence 205163 from Patent EP1572962.
JD373805 - Sequence 354829 from Patent EP1572962.
AB041943 - Homo sapiens KPG_010 mRNA for G-protein coupled receptor, complete cds.
JD074241 - Sequence 55265 from Patent EP1572962.
AJ272207 - Homo sapiens mRNA for putative G protein-coupled receptor 92 (GPR92 gene).
AK313127 - Homo sapiens cDNA, FLJ93614, Homo sapiens G protein-coupled receptor 92 (GPR92), mRNA.
KJ894394 - Synthetic construct Homo sapiens clone ccsbBroadEn_03788 LPAR5 gene, encodes complete protein.
DQ892897 - Synthetic construct clone IMAGE:100005527; FLH191870.01X; RZPDo839H1077D G protein-coupled receptor 92 (GPR92) gene, encodes complete protein.
DQ896145 - Synthetic construct Homo sapiens clone IMAGE:100010605; FLH191866.01L; RZPDo839H1067D G protein-coupled receptor 92 (GPR92) gene, encodes complete protein.
CU689654 - Synthetic construct Homo sapiens gateway clone IMAGE:100021904 5' read GPR92 mRNA.
JD101815 - Sequence 82839 from Patent EP1572962.
JD171887 - Sequence 152911 from Patent EP1572962.
JD104548 - Sequence 85572 from Patent EP1572962.
JD317548 - Sequence 298572 from Patent EP1572962.
JD548411 - Sequence 529435 from Patent EP1572962.
JD508268 - Sequence 489292 from Patent EP1572962.
JD365303 - Sequence 346327 from Patent EP1572962.
JD208238 - Sequence 189262 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9H1C0 (Reactome details) participates in the following event(s):

R-HSA-419389 LPA-binding receptors bind LPA
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-419408 Lysosphingolipid and LPA receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-416476 G alpha (q) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: GPR92, GPR93, LPAR5_HUMAN, NM_001142961, Q9H1C0, uc009zer.1, uc009zer.2
UCSC ID: ENST00000431922.1
RefSeq Accession: NM_001142961
Protein: Q9H1C0 (aka LPAR5_HUMAN)
CCDS: CCDS8553.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.