Human Gene MAP2K1 (ENST00000307102.10) from GENCODE V39
  Description: Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNA. (from RefSeq NM_002755)
RefSeq Summary (NM_002755): The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000307102.10
Gencode Gene: ENSG00000169032.11
Transcript (Including UTRs)
   Position: hg38 chr15:66,386,912-66,491,544 Size: 104,633 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg38 chr15:66,387,348-66,490,615 Size: 103,268 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesGeneReviewsMethods
Data last updated at UCSC: 2022-01-17 08:30:34

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:66,386,912-66,491,544)mRNA (may differ from genome)Protein (393 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
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HGNCHPRDLynxMGIneXtProtOMIM
PubMedReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: MP2K1_HUMAN
DESCRIPTION: RecName: Full=Dual specificity mitogen-activated protein kinase kinase 1; Short=MAP kinase kinase 1; Short=MAPKK 1; Short=MKK1; EC=2.7.12.2; AltName: Full=ERK activator kinase 1; AltName: Full=MAPK/ERK kinase 1; Short=MEK 1;
FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator- activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
ENZYME REGULATION: Ras proteins such as HRAS mediate the activation of RAF proteins such as RAF1 or BRAF which in turn activate extracellular signal-regulated kinases (ERK) through MAPK (mitogen-activated protein kinases) and ERK kinases MAP2K1/MEK1 and MAP2K2/MEK2. Activation occurs through phosphorylation of Ser- 218 and Ser-222. MAP2K1/MEK1 is also the target of negative feed- back regulation by its substrate kinases, such as MAPK1/ERK2. These phosphorylate MAP2K1/MEK1 on Thr-292, thereby facilitating dephosphorylation of the activating residues Ser-218 and Ser-222. Inhibited by serine/threonine phosphatase 2A (By similarity). Many inhibitors have been identified including pyrrole derivatives, TAK-733 (one of a series of 8-methylpyrido[2,3-d]pyrimidine- 4,7(3H,8H)-dione derivatives), CH4987655 and RDEA119/BAY 869766.
SUBUNIT: Found in a complex with at least BRAF, HRAS1, MAP2K1, MAPK3/ERK1 and RGS14 (By similarity). Forms a heterodimer with MAP2K2/MEK2 (By similarity). Forms heterodimers with KSR2 which further dimerize to form tetramers (By similarity). Interacts with ARBB2, LAMTOR3, MAPK1/ERK2, MORG1 and RAF1 (By similarity). Interacts with PPARG and with isoform 1 of VRK2. Interacts with Yersinia yopJ. Interacts with SGK1. Interacts with BIRC6/bruce.
INTERACTION: Q9NR09:BIRC6; NbExp=2; IntAct=EBI-492564, EBI-1765160; P04049:RAF1; NbExp=2; IntAct=EBI-492564, EBI-365996; Q86Y07:VRK2; NbExp=2; IntAct=EBI-492564, EBI-1207615; Q86Y07-1:VRK2; NbExp=2; IntAct=EBI-492564, EBI-1207633;
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole body. Cytoplasm. Nucleus. Note=Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis.
TISSUE SPECIFICITY: Widely expressed, with extremely low levels in brain.
DOMAIN: The proline-rich region localized between residues 270 and 307 is important for binding to RAF1 and activation of MAP2K1/MEK1 (By similarity).
PTM: Phosphorylation at Ser-218 and Ser-222 by MAP kinase kinase kinases (RAF or MEKK1) positively regulates kinase activity. Also phosphorylated at Thr-292 by MAPK1/ERK2 and at Ser-298 by PAK. MAPK1/ERK2 phosphorylation of Thr-292 occurs in response to cellular adhesion and leads to inhibition of Ser-298 phosphorylation by PAK.
PTM: Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
DISEASE: Defects in MAP2K1 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio- cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.
SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
SIMILARITY: Contains 1 protein kinase domain.
WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MAP2K1";

-  MalaCards Disease Associations
  MalaCards Gene Search: MAP2K1
Diseases sorted by gene-association score: cardiofaciocutaneous syndrome 3* (1229), cardiofaciocutaneous syndrome* (466), melanoma* (218), map2k1-related cardiofaciocutaneous syndrome* (100), map2k1-related noonan syndrome* (100), ovarian melanoma (19), extracranial arteriovenous malformation (18), costello syndrome (15), splenic diffuse red pulp small b-cell lymphoma (13), cerebral hemisphere lipoma (10), corpus callosum lipoma (10), achondroplasia (10), drug addiction (9), pulmonic stenosis (9), histiocytosis (7), letterer-siwe disease (7), noonan syndrome 1 (7), senile angioma (6), acneiform dermatitis (5), pancreatic cancer (5), juvenile pilocytic astrocytoma (4), spinocerebellar ataxia 10 (4), colorectal cancer (3), lung cancer (3), renal cell carcinoma (3), prostate cancer (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 52.13 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 796.34 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -235.70436-0.541 Picture PostScript Text
3' UTR -223.70929-0.241 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1S9J - X-ray MuPIT 2P55 - X-ray MuPIT 3DV3 - X-ray MuPIT 3DY7 - X-ray MuPIT 3E8N - X-ray MuPIT 3EQB - X-ray MuPIT 3EQC - X-ray MuPIT 3EQD - X-ray MuPIT 3EQF - X-ray MuPIT 3EQG - X-ray MuPIT 3EQH - X-ray MuPIT 3EQI - X-ray MuPIT 3MBL - X-ray MuPIT 3ORN - X-ray MuPIT 3OS3 - X-ray 3PP1 - X-ray MuPIT 3SLS - X-ray MuPIT 3V01 - X-ray MuPIT 3V04 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q02750
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl WormBase 
Protein SequenceProtein SequenceProtein Sequence Protein Sequence 
AlignmentAlignmentAlignment Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004728 signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0043539 protein serine/threonine kinase activator activity
GO:0047485 protein N-terminus binding
GO:0097110 scaffold protein binding

Biological Process:
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0001932 regulation of protein phosphorylation
GO:0006468 protein phosphorylation
GO:0006935 chemotaxis
GO:0007050 cell cycle arrest
GO:0007165 signal transduction
GO:0007346 regulation of mitotic cell cycle
GO:0007507 heart development
GO:0008285 negative regulation of cell proliferation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016310 phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021697 cerebellar cortex formation
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0030878 thyroid gland development
GO:0032872 regulation of stress-activated MAPK cascade
GO:0042981 regulation of apoptotic process
GO:0045597 positive regulation of cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048538 thymus development
GO:0048679 regulation of axon regeneration
GO:0048870 cell motility
GO:0050772 positive regulation of axonogenesis
GO:0060020 Bergmann glial cell differentiation
GO:0060324 face development
GO:0060425 lung morphogenesis
GO:0060440 trachea formation
GO:0060502 epithelial cell proliferation involved in lung morphogenesis
GO:0060674 placenta blood vessel development
GO:0060711 labyrinthine layer development
GO:0070371 ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090170 regulation of Golgi inheritance
GO:0090398 cellular senescence
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:2000641 regulation of early endosome to late endosome transport

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  AK291500 - Homo sapiens cDNA FLJ76051 complete cds, highly similar to Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNA.
AK312356 - Homo sapiens cDNA, FLJ92675.
BC137459 - Homo sapiens mitogen-activated protein kinase kinase 1, mRNA (cDNA clone MGC:169082 IMAGE:9021459), complete cds.
L11284 - Homosapiens ERK activator kinase (MEK1) mRNA.
BC139729 - Homo sapiens mitogen-activated protein kinase kinase 1, mRNA (cDNA clone MGC:133320 IMAGE:40053655), complete cds.
L05624 - Homo sapiens MAP kinase kinase mRNA, complete cds.
AB528554 - Synthetic construct DNA, clone: pF1KE0668, Homo sapiens MAP2K1 gene for mitogen-activated protein kinase kinase 1, without stop codon, in Flexi system.
AK294322 - Homo sapiens cDNA FLJ58770 complete cds, highly similar to Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2).
JD265741 - Sequence 246765 from Patent EP1572962.
JD466605 - Sequence 447629 from Patent EP1572962.
DQ583973 - Homo sapiens piRNA piR-51085, complete sequence.
JD082217 - Sequence 63241 from Patent EP1572962.
JD119788 - Sequence 100812 from Patent EP1572962.
JD037100 - Sequence 18124 from Patent EP1572962.
JD050087 - Sequence 31111 from Patent EP1572962.
JD292612 - Sequence 273636 from Patent EP1572962.
JD271595 - Sequence 252619 from Patent EP1572962.
JD470746 - Sequence 451770 from Patent EP1572962.
JD532045 - Sequence 513069 from Patent EP1572962.
JD414261 - Sequence 395285 from Patent EP1572962.
JD019085 - Sequence 109 from Patent EP1572962.
JD048070 - Sequence 29094 from Patent EP1572962.
JD033544 - Sequence 14568 from Patent EP1572962.
JD233222 - Sequence 214246 from Patent EP1572962.
JD087381 - Sequence 68405 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04012 - ErbB signaling pathway
hsa04062 - Chemokine signaling pathway
hsa04114 - Oocyte meiosis
hsa04270 - Vascular smooth muscle contraction
hsa04320 - Dorso-ventral axis formation
hsa04370 - VEGF signaling pathway
hsa04510 - Focal adhesion
hsa04540 - Gap junction
hsa04620 - Toll-like receptor signaling pathway
hsa04650 - Natural killer cell mediated cytotoxicity
hsa04660 - T cell receptor signaling pathway
hsa04662 - B cell receptor signaling pathway
hsa04664 - Fc epsilon RI signaling pathway
hsa04666 - Fc gamma R-mediated phagocytosis
hsa04720 - Long-term potentiation
hsa04722 - Neurotrophin signaling pathway
hsa04730 - Long-term depression
hsa04810 - Regulation of actin cytoskeleton
hsa04910 - Insulin signaling pathway
hsa04912 - GnRH signaling pathway
hsa04914 - Progesterone-mediated oocyte maturation
hsa04916 - Melanogenesis
hsa05020 - Prion diseases
hsa05200 - Pathways in cancer
hsa05210 - Colorectal cancer
hsa05211 - Renal cell carcinoma
hsa05212 - Pancreatic cancer
hsa05213 - Endometrial cancer
hsa05214 - Glioma
hsa05215 - Prostate cancer
hsa05216 - Thyroid cancer
hsa05218 - Melanoma
hsa05219 - Bladder cancer
hsa05220 - Chronic myeloid leukemia
hsa05221 - Acute myeloid leukemia
hsa05223 - Non-small cell lung cancer

BioCyc Knowledge Library
PWY66-14 - MAP kinase cascade

BioCarta from NCI Cancer Genome Anatomy Project
h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells
h_il2Pathway - IL 2 signaling pathway
h_malPathway - Role of MAL in Rho-Mediated Activation of SRF
h_bArrestin-srcPathway - Roles of -arrestin-dependent Recruitment of Src Kinases in GPCR Signaling
h_bcrPathway - BCR Signaling Pathway
h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway
h_her2Pathway - Role of ERBB2 in Signal Transduction and Oncology
h_igf1Pathway - IGF-1 Signaling Pathway
h_integrinPathway - Integrin Signaling Pathway
h_nkcellsPathway - Ras-Independent pathway in NK cell-mediated cytotoxicity
h_rasPathway - Ras Signaling Pathway
h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling
h_cdMacPathway - Cadmium induces DNA synthesis and proliferation in macrophages
h_cdk5Pathway - Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway
h_egfr_smrtePathway - Map Kinase Inactivation of SMRT Corepressor
h_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells
h_gleevecpathway - Inhibition of Cellular Proliferation by Gleevec
h_gpcrPathway - Signaling Pathway from G-Protein Families
h_ngfPathway - Nerve growth factor pathway (NGF)
h_pyk2Pathway - Links between Pyk2 and Map Kinases
h_spryPathway - Sprouty regulation of tyrosine kinase signals
h_tcrPathway - T Cell Receptor Signaling Pathway
h_CCR3Pathway - CCR3 signaling in Eosinophils
h_TPOPathway - TPO Signaling Pathway
h_anthraxPathway - Anthrax Toxin Mechanism of Action
h_barr-mapkPathway - Role of -arrestins in the activation and targeting of MAP kinases
h_ghPathway - Growth Hormone Signaling Pathway
h_il3Pathway - IL 3 signaling pathway
h_insulinPathway - Insulin Signaling Pathway
h_ceramidePathway - Ceramide Signaling Pathway
h_egfPathway - EGF Signaling Pathway
h_il6Pathway - IL 6 signaling pathway
h_metPathway - Signaling of Hepatocyte Growth Factor Receptor
h_keratinocytePathway - Keratinocyte Differentiation
h_pdgfPathway - PDGF Signaling Pathway
h_ecmPathway - Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia
h_igf1rPathway - Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation
h_cxcr4Pathway - CXCR4 Signaling Pathway
h_epoPathway - EPO Signaling Pathway
h_erkPathway - Erk1/Erk2 Mapk Signaling pathway
h_hcmvPathway - Human Cytomegalovirus and Map Kinase Pathways
h_mapkPathway - MAPKinase Signaling Pathway
h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart)
h_sppaPathway - Aspirin Blocks Signaling Pathway Involved in Platelet Activation
h_tgfbPathway - TGF beta signaling pathway

Reactome (by CSHL, EBI, and GO)

Protein Q02750 (Reactome details) participates in the following event(s):

R-HSA-5211340 Anthrax LF cleaves target cell MAP2K1 (MEK1)
R-HSA-109857 MAP2K1 binds MAPK3
R-HSA-112342 Inactivation of MAP2K1 by CDK1
R-HSA-451649 TPL2 phosphorylates MEK1, SEK1
R-HSA-109860 MAP2K1 phosphorylates MAPK3
R-HSA-5674496 Activated MAPKs phosphorylate MAP2K1
R-HSA-5672972 MAP2Ks and MAPKs bind to the activated RAF complex
R-HSA-5674132 WDR83:LAMTOR2:LAMTOR3 binds MAPK components
R-HSA-6802912 High kinase activity BRAF mutants bind MAP2Ks and MAPKs
R-HSA-6802914 RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs
R-HSA-6802925 Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs
R-HSA-6802934 p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs
R-HSA-6802942 RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs
R-HSA-5674366 IL17RD binds p-2S MAP2Ks and MAPKs
R-HSA-5672980 Dissociation of RAS:RAF complex
R-HSA-6802932 Dissociation of BRAF/RAF fusion complex
R-HSA-6803227 Dissociation of high activity BRAF complexes
R-HSA-6803230 Dissociation of moderate activity BRAF complexes
R-HSA-6803233 Dissociation of oncogenic RAS:RAF complex
R-HSA-6803234 Dissociation of paradoxically activated RAS:BRAF complexes
R-HSA-5672978 RAF phosphorylates MAP2K dimer
R-HSA-6802943 RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks
R-HSA-6802919 RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks
R-HSA-6802911 High kinase activity BRAF complexes phosphorylate MAP2Ks
R-HSA-6802926 Mutant RAS:p-RAF complexes phosphorylate MAP2Ks
R-HSA-6802933 p-BRAF and RAF fusion dimers phosphorylate MAP2Ks
R-HSA-5672973 MAP2Ks phosphorylate MAPKs
R-HSA-5674373 MAP2Ks phosphorylate MAPK at the Golgi membrane
R-HSA-6802918 Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants
R-HSA-6802921 Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants
R-HSA-6802910 Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants
R-HSA-6802922 Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS
R-HSA-6802935 MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers
R-HSA-5672969 Phosphorylation of RAF
R-HSA-6802916 RAF is phosphorylated downstream of moderate kinase activity BRAF mutants
R-HSA-6802924 RAF is phosphorylated downstream of oncogenic RAS
R-HSA-6802927 BRAF and RAF fusion mutant dimers are phosphorylated
R-HSA-6802941 RAF is paradoxically phosphorylated downstream of kinase-inactive RAF
R-HSA-5210891 Uptake and function of anthrax toxins
R-HSA-110056 MAPK3 (ERK1) activation
R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-HSA-5339562 Uptake and actions of bacterial toxins
R-HSA-445144 Signal transduction by L1
R-HSA-5674499 Negative feedback regulation of MAPK pathway
R-HSA-112409 RAF-independent MAPK1/3 activation
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-450294 MAP kinase activation
R-HSA-9020702 Interleukin-1 signaling
R-HSA-5663205 Infectious disease
R-HSA-373760 L1CAM interactions
R-HSA-5675221 Negative regulation of MAPK pathway
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6802957 Oncogenic MAPK signaling
R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-448424 Interleukin-17 signaling
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-446652 Interleukin-1 family signaling
R-HSA-1643685 Disease
R-HSA-422475 Axon guidance
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5663202 Diseases of signal transduction
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168898 Toll-Like Receptors Cascades
R-HSA-449147 Signaling by Interleukins
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-1266738 Developmental Biology
R-HSA-5673000 RAF activation
R-HSA-162582 Signal Transduction
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-168249 Innate Immune System
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000307102.1, ENST00000307102.2, ENST00000307102.3, ENST00000307102.4, ENST00000307102.5, ENST00000307102.6, ENST00000307102.7, ENST00000307102.8, ENST00000307102.9, MEK1, MP2K1_HUMAN, NM_002755, PRKMK1, Q02750, uc010bhq.1, uc010bhq.2, uc010bhq.3, uc010bhq.4, uc010bhq.5
UCSC ID: ENST00000307102.10
RefSeq Accession: NM_002755
Protein: Q02750 (aka MP2K1_HUMAN or MPK1_HUMAN)
CCDS: CCDS10216.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene MAP2K1:
leopard (Noonan Syndrome with Multiple Lentigines)
cfc (Cardiofaciocutaneous Syndrome)
noonan (Noonan Syndrome)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.