ID:S28A1_HUMAN DESCRIPTION: RecName: Full=Sodium/nucleoside cotransporter 1; AltName: Full=Concentrative nucleoside transporter 1; Short=CNT 1; Short=hCNT1; AltName: Full=Na(+)/nucleoside cotransporter 1; AltName: Full=Sodium-coupled nucleoside transporter 1; AltName: Full=Solute carrier family 28 member 1; FUNCTION: Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in kidney. POLYMORPHISM: Three variant forms of isoform 1 (A, B and C) are expressed in the kidney. All three variant forms have similar nucleoside transport activity. SIMILARITY: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00337
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006139 nucleobase-containing compound metabolic process GO:0015855 pyrimidine nucleobase transport GO:0015858 nucleoside transport GO:0072531 pyrimidine-containing compound transmembrane transport GO:1901642 nucleoside transmembrane transport GO:1904823 purine nucleobase transmembrane transport
AK296075 - Homo sapiens cDNA FLJ58165 complete cds, highly similar to Sodium/nucleoside cotransporter 1. AK291997 - Homo sapiens cDNA FLJ77431 complete cds, highly similar to Human Na+/nucleoside cotransporter (hCNT1c) mRNA. AK298369 - Homo sapiens cDNA FLJ56538 complete cds, highly similar to Sodium/nucleoside cotransporter 1. AK296074 - Homo sapiens cDNA FLJ58112 complete cds, highly similar to Sodium/nucleoside cotransporter 1. U62966 - Human Na+/nucleoside cotransporter (hCNT1a) mRNA, complete cds. AF309632 - Homo sapiens concentrative nucleoside transporter 1 mRNA, complete cds. LF384286 - JP 2014500723-A/191789: Polycomb-Associated Non-Coding RNAs. MA619863 - JP 2018138019-A/191789: Polycomb-Associated Non-Coding RNAs. BC126204 - Homo sapiens solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, mRNA (cDNA clone MGC:161482 IMAGE:8991920), complete cds. BC126206 - Homo sapiens solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, mRNA (cDNA clone MGC:161484 IMAGE:8991922), complete cds. BC143908 - Homo sapiens cDNA clone IMAGE:9052426. U62967 - Human Na+/nucleoside cotransporter (hCNT1b) mRNA, complete cds. U62968 - Human Na+/nucleoside cotransporter (hCNT1c) mRNA, complete cds. HQ258352 - Synthetic construct Homo sapiens clone IMAGE:100072661 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 (SLC28A1), transcript variant 1 (SLC28A1) gene, encodes complete protein. KJ897974 - Synthetic construct Homo sapiens clone ccsbBroadEn_07368 SLC28A1 gene, encodes complete protein. KR711658 - Synthetic construct Homo sapiens clone CCSBHm_00028241 SLC28A1 (SLC28A1) mRNA, encodes complete protein. KR711659 - Synthetic construct Homo sapiens clone CCSBHm_00028242 SLC28A1 (SLC28A1) mRNA, encodes complete protein. AK311387 - Homo sapiens cDNA, FLJ18429. AK309571 - Homo sapiens cDNA, FLJ99612. AK296119 - Homo sapiens cDNA FLJ51869 complete cds, highly similar to Sodium/nucleoside cotransporter 1. AK309578 - Homo sapiens cDNA, FLJ99619. BC029788 - Homo sapiens solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, mRNA (cDNA clone IMAGE:5187406), complete cds. BC039898 - Homo sapiens solute carrier family 28 (sodium-coupled nucleoside transporter), member 1, mRNA (cDNA clone IMAGE:5188608), complete cds. LF368532 - JP 2014500723-A/176035: Polycomb-Associated Non-Coding RNAs. MA604109 - JP 2018138019-A/176035: Polycomb-Associated Non-Coding RNAs. JD162282 - Sequence 143306 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O00337 (Reactome details) participates in the following event(s):
R-HSA-109530 Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 R-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane R-HSA-425397 Transport of vitamins, nucleosides, and related molecules R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules
US Server
