Human Gene TACC1 (ENST00000317827.9) from GENCODE V44
  Description: Homo sapiens transforming acidic coiled-coil containing protein 1 (TACC1), transcript variant 1, mRNA. (from RefSeq NM_006283)
RefSeq Summary (NM_006283): This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017].
Gencode Transcript: ENST00000317827.9
Gencode Gene: ENSG00000147526.20
Transcript (Including UTRs)
   Position: hg38 chr8:38,787,236-38,853,028 Size: 65,793 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg38 chr8:38,787,583-38,848,023 Size: 60,441 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr8:38,787,236-38,853,028)mRNA (may differ from genome)Protein (805 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Transforming acidic coiled-coil-containing protein 1; AltName: Full=Gastric cancer antigen Ga55; AltName: Full=Taxin-1;
FUNCTION: Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.
SUBUNIT: Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with AURKA, AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF.
INTERACTION: Q96GD4:AURKB; NbExp=2; IntAct=EBI-624278, EBI-624291; Q14008:CKAP5; NbExp=3; IntAct=EBI-624237, EBI-310585; Q9UK45:LSM7; NbExp=4; IntAct=EBI-624252, EBI-348372; P62308:SNRPG; NbExp=5; IntAct=EBI-624252, EBI-624585; Q8NHU6:TDRD7; NbExp=4; IntAct=EBI-624237, EBI-624505; O95619:YEATS4; NbExp=6; IntAct=EBI-624237, EBI-399269;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome. Note=Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis.
TISSUE SPECIFICITY: Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.
DEVELOPMENTAL STAGE: Expressed at high level during early embryogenesis.
PTM: Isoform 1 is heavily phosphorylated; isoform 6 is not. Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the TACC family.
SIMILARITY: Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="";

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  MalaCards Disease Associations
  MalaCards Gene Search: TACC1
Diseases sorted by gene-association score: gliosarcoma* (202), giant cell glioblastoma* (132), breast cancer (3)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 57.86 RPKM in Esophagus - Muscularis
Total median expression: 1170.95 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -170.90347-0.493 Picture PostScript Text
3' UTR -1366.375005-0.273 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007707 - TACC

Pfam Domains:
PF05010 - Transforming acidic coiled-coil-containing protein (TACC)

ModBase Predicted Comparative 3D Structure on O75410
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0000226 microtubule cytoskeleton organization
GO:0007049 cell cycle
GO:0008283 cell proliferation
GO:0021987 cerebral cortex development
GO:0051301 cell division

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0030496 midbody

-  Descriptions from all associated GenBank mRNAs
  BX647696 - Homo sapiens mRNA; cDNA DKFZp686K18126 (from clone DKFZp686K18126).
AY072873 - Homo sapiens transforming, acidic coiled-coil containing protein 1 variant TACC1-B (TACC1) mRNA, partial cds; alternatively spliced.
AY072876 - Homo sapiens transforming, acidic coiled-coil containing protein 1 variant TACC1-E (TACC1) mRNA, partial cds; alternatively spliced.
AK304774 - Homo sapiens cDNA FLJ52058 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AK295071 - Homo sapiens cDNA FLJ50409 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AK303596 - Homo sapiens cDNA FLJ52382 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AK304507 - Homo sapiens cDNA FLJ56209 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
BC041391 - Homo sapiens transforming, acidic coiled-coil containing protein 1, mRNA (cDNA clone MGC:43967 IMAGE:5276767), complete cds.
JF432777 - Synthetic construct Homo sapiens clone IMAGE:100074021 transforming, acidic coiled-coil containing protein 1 (TACC1) gene, encodes complete protein.
KJ901774 - Synthetic construct Homo sapiens clone ccsbBroadEn_11168 TACC1 gene, encodes complete protein.
AY072874 - Homo sapiens transforming, acidic coiled-coil containing protein 1 variant TACC1-C (TACC1) mRNA, partial cds; alternatively spliced.
AY072875 - Homo sapiens transforming, acidic coiled-coil containing protein 1 variant TACC1-D (TACC1) mRNA, partial cds; alternatively spliced.
AK308849 - Homo sapiens cDNA, FLJ98890.
AK314620 - Homo sapiens cDNA, FLJ95461, highly similar to Homo sapiens transforming, acidic coiled-coil containing protein 1 (TACC1), mRNA.
AF049910 - Homo sapiens TACC1 (TACC1) mRNA, complete cds.
AY177411 - Homo sapiens transforming acidic coiled-coil containing protein 1 short isoform (TACC1) mRNA, complete cds.
AB463317 - Synthetic construct DNA, clone: pF1KB9572, Homo sapiens TACC1 gene for transforming, acidic coiled-coil containing protein 1, without stop codon, in Flexi system.
AK294931 - Homo sapiens cDNA FLJ50512 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
JD217099 - Sequence 198123 from Patent EP1572962.
JD478371 - Sequence 459395 from Patent EP1572962.
JD396735 - Sequence 377759 from Patent EP1572962.
JD465212 - Sequence 446236 from Patent EP1572962.
JD123256 - Sequence 104280 from Patent EP1572962.
JD392758 - Sequence 373782 from Patent EP1572962.
JD140389 - Sequence 121413 from Patent EP1572962.
AK295841 - Homo sapiens cDNA FLJ50411 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AB029026 - Homo sapiens mRNA for KIAA1103 protein, partial cds.
AK304725 - Homo sapiens cDNA FLJ52297 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AY039239 - Homo sapiens gastric cancer antigen Ga55 (TACC1) mRNA, partial cds.
AY139007 - Homo sapiens TACC1-like protein mRNA, complete cds.
AK098223 - Homo sapiens cDNA FLJ40904 fis, clone UTERU2004564.
JD269219 - Sequence 250243 from Patent EP1572962.
JD518997 - Sequence 500021 from Patent EP1572962.
JD232862 - Sequence 213886 from Patent EP1572962.
JD460356 - Sequence 441380 from Patent EP1572962.
JD562431 - Sequence 543455 from Patent EP1572962.
JD090700 - Sequence 71724 from Patent EP1572962.
JD432693 - Sequence 413717 from Patent EP1572962.
JD097217 - Sequence 78241 from Patent EP1572962.
JD366946 - Sequence 347970 from Patent EP1572962.
JD488925 - Sequence 469949 from Patent EP1572962.
JD215340 - Sequence 196364 from Patent EP1572962.
JD066446 - Sequence 47470 from Patent EP1572962.
JD299305 - Sequence 280329 from Patent EP1572962.
JD111988 - Sequence 93012 from Patent EP1572962.
JD498058 - Sequence 479082 from Patent EP1572962.
JD564664 - Sequence 545688 from Patent EP1572962.
JD416178 - Sequence 397202 from Patent EP1572962.
JD082630 - Sequence 63654 from Patent EP1572962.
JD061437 - Sequence 42461 from Patent EP1572962.
JD451221 - Sequence 432245 from Patent EP1572962.
JD376142 - Sequence 357166 from Patent EP1572962.
JD376143 - Sequence 357167 from Patent EP1572962.
JD498039 - Sequence 479063 from Patent EP1572962.
JD553521 - Sequence 534545 from Patent EP1572962.
JD162576 - Sequence 143600 from Patent EP1572962.
JD170382 - Sequence 151406 from Patent EP1572962.
JD431286 - Sequence 412310 from Patent EP1572962.
JD564036 - Sequence 545060 from Patent EP1572962.
JD557159 - Sequence 538183 from Patent EP1572962.
JD130376 - Sequence 111400 from Patent EP1572962.
JD146138 - Sequence 127162 from Patent EP1572962.
JD146139 - Sequence 127163 from Patent EP1572962.
JD074371 - Sequence 55395 from Patent EP1572962.
JD197165 - Sequence 178189 from Patent EP1572962.
JD472616 - Sequence 453640 from Patent EP1572962.
JD498220 - Sequence 479244 from Patent EP1572962.
JD277192 - Sequence 258216 from Patent EP1572962.
JD215937 - Sequence 196961 from Patent EP1572962.
JD470717 - Sequence 451741 from Patent EP1572962.
JD377628 - Sequence 358652 from Patent EP1572962.
JD088620 - Sequence 69644 from Patent EP1572962.
JD267398 - Sequence 248422 from Patent EP1572962.
JD447678 - Sequence 428702 from Patent EP1572962.
JD085109 - Sequence 66133 from Patent EP1572962.
JD249564 - Sequence 230588 from Patent EP1572962.
JD378010 - Sequence 359034 from Patent EP1572962.
JD354049 - Sequence 335073 from Patent EP1572962.
JD269657 - Sequence 250681 from Patent EP1572962.
JD189797 - Sequence 170821 from Patent EP1572962.
JD251491 - Sequence 232515 from Patent EP1572962.
JD036424 - Sequence 17448 from Patent EP1572962.
JD036748 - Sequence 17772 from Patent EP1572962.
JD433674 - Sequence 414698 from Patent EP1572962.
JD234837 - Sequence 215861 from Patent EP1572962.
JD483720 - Sequence 464744 from Patent EP1572962.
JD048828 - Sequence 29852 from Patent EP1572962.
JD369324 - Sequence 350348 from Patent EP1572962.
JD300223 - Sequence 281247 from Patent EP1572962.
JD314705 - Sequence 295729 from Patent EP1572962.
DQ601424 - Homo sapiens piRNA piR-39490, complete sequence.
JD170964 - Sequence 151988 from Patent EP1572962.
JD554021 - Sequence 535045 from Patent EP1572962.
JD516773 - Sequence 497797 from Patent EP1572962.
JD313559 - Sequence 294583 from Patent EP1572962.
JD343373 - Sequence 324397 from Patent EP1572962.
JD378971 - Sequence 359995 from Patent EP1572962.
JD389673 - Sequence 370697 from Patent EP1572962.
JD292900 - Sequence 273924 from Patent EP1572962.
JD061641 - Sequence 42665 from Patent EP1572962.
JD281080 - Sequence 262104 from Patent EP1572962.
JD209510 - Sequence 190534 from Patent EP1572962.
JD333433 - Sequence 314457 from Patent EP1572962.
JD182987 - Sequence 164011 from Patent EP1572962.
JD093916 - Sequence 74940 from Patent EP1572962.
AF075051 - Homo sapiens full length insert cDNA YN99C01.
JD355069 - Sequence 336093 from Patent EP1572962.
JD552697 - Sequence 533721 from Patent EP1572962.
JD363699 - Sequence 344723 from Patent EP1572962.
JD368311 - Sequence 349335 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RBD9, D3DSX6, ENST00000317827.1, ENST00000317827.2, ENST00000317827.3, ENST00000317827.4, ENST00000317827.5, ENST00000317827.6, ENST00000317827.7, ENST00000317827.8, KIAA1103, NM_006283, O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9, TACC1_HUMAN, uc010lwp.1, uc010lwp.2, uc010lwp.3, uc010lwp.4
UCSC ID: ENST00000317827.9
RefSeq Accession: NM_006283
Protein: O75410 (aka TACC1_HUMAN or TAC1_HUMAN)
CCDS: CCDS6109.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.