Human Gene ZNF7 (ENST00000446747.7) from GENCODE V44
  Description: Homo sapiens zinc finger protein 7 (ZNF7), transcript variant 10, mRNA. (from RefSeq NM_001349809)
Gencode Transcript: ENST00000446747.7
Gencode Gene: ENSG00000147789.16
Transcript (Including UTRs)
   Position: hg38 chr8:144,827,559-144,843,772 Size: 16,214 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr8:144,829,088-144,843,168 Size: 14,081 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:144,827,559-144,843,772)mRNA (may differ from genome)Protein (697 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDMalacardsMGIneXtProtOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZNF7_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 7; AltName: Full=Zinc finger protein HF.16; AltName: Full=Zinc finger protein KOX4;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
TISSUE SPECIFICITY: Ubiquitously present in many human cell lines of different embryological derivation.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 15 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.18 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 84.36 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -36.2096-0.377 Picture PostScript Text
3' UTR -194.20604-0.322 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF01352 - KRAB box
PF00096 - Zinc finger, C2H2 type

ModBase Predicted Comparative 3D Structure on P17097
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007275 multicellular organism development

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  LF385052 - JP 2014500723-A/192555: Polycomb-Associated Non-Coding RNAs.
MA620629 - JP 2018138019-A/192555: Polycomb-Associated Non-Coding RNAs.
AK308002 - Homo sapiens cDNA, FLJ97950.
AK301561 - Homo sapiens cDNA FLJ55889 complete cds, highly similar to Zinc finger protein 7.
AK096025 - Homo sapiens cDNA FLJ38706 fis, clone KIDNE2002795, moderately similar to ZINC FINGER PROTEIN 7.
BX647998 - Homo sapiens mRNA; cDNA DKFZp686A0959 (from clone DKFZp686A0959).
BC058923 - Homo sapiens zinc finger protein 7, mRNA (cDNA clone MGC:65112 IMAGE:4516166), complete cds.
AK313745 - Homo sapiens cDNA, FLJ94346, highly similar to Homo sapiens zinc finger protein 7 (KOX 4, clone HF.16) (ZNF7), mRNA.
AK300001 - Homo sapiens cDNA FLJ54719 complete cds, highly similar to Zinc finger protein 7.
M29580 - Human zinc-finger protein 7 (ZFP7) mRNA, complete cds.
AB590742 - Synthetic construct DNA, clone: pFN21AE1178, Homo sapiens ZNF7 gene for zinc finger protein 7, without stop codon, in Flexi system.
EU446716 - Synthetic construct Homo sapiens clone IMAGE:100070222; IMAGE:100011925; FLH258748.01L zinc finger protein 7 (ZNF7) gene, encodes complete protein.
AB209619 - Homo sapiens mRNA for zinc finger protein 7 (KOX 4, clone HF.16) variant protein.
LF337165 - JP 2014500723-A/144668: Polycomb-Associated Non-Coding RNAs.
MA572742 - JP 2018138019-A/144668: Polycomb-Associated Non-Coding RNAs.
DQ599197 - Homo sapiens piRNA piR-37263, complete sequence.
LF337166 - JP 2014500723-A/144669: Polycomb-Associated Non-Coding RNAs.
MA572743 - JP 2018138019-A/144669: Polycomb-Associated Non-Coding RNAs.
AF027146 - Homo sapiens clone B2-5 zinc finger protein mRNA, partial cds.
LF337167 - JP 2014500723-A/144670: Polycomb-Associated Non-Coding RNAs.
MA572744 - JP 2018138019-A/144670: Polycomb-Associated Non-Coding RNAs.
U71599 - Human zinc finger protein zfp30 (zf30) mRNA, partial cds.
X52335 - Human Kox4 mRNA for zinc finger protein, partial.
AK022466 - Homo sapiens cDNA FLJ12404 fis, clone MAMMA1002833.
LF337168 - JP 2014500723-A/144671: Polycomb-Associated Non-Coding RNAs.
MA572745 - JP 2018138019-A/144671: Polycomb-Associated Non-Coding RNAs.
JD050378 - Sequence 31402 from Patent EP1572962.
JD097705 - Sequence 78729 from Patent EP1572962.
JD222182 - Sequence 203206 from Patent EP1572962.
JD545843 - Sequence 526867 from Patent EP1572962.
JD545842 - Sequence 526866 from Patent EP1572962.
JD487512 - Sequence 468536 from Patent EP1572962.
JD079666 - Sequence 60690 from Patent EP1572962.
JD243298 - Sequence 224322 from Patent EP1572962.
JD243297 - Sequence 224321 from Patent EP1572962.
JD079665 - Sequence 60689 from Patent EP1572962.
JD171565 - Sequence 152589 from Patent EP1572962.
JD238468 - Sequence 219492 from Patent EP1572962.
JD047770 - Sequence 28794 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DWN6, ENST00000446747.1, ENST00000446747.2, ENST00000446747.3, ENST00000446747.4, ENST00000446747.5, ENST00000446747.6, KOX4, NM_001349809, P17015, P17097, uc010mge.1, uc010mge.2, uc010mge.3, uc010mge.4, uc010mge.5, uc010mge.6, ZNF7_HUMAN
UCSC ID: ENST00000446747.7
RefSeq Accession: NM_001282795
Protein: P17097 (aka ZNF7_HUMAN or ZN07_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.