Human Gene NEAT1 (ENST00000501122.2) from GENCODE V44
  Description: Homo sapiens nuclear paraspeckle assembly transcript 1 (NEAT1), transcript variant MENbeta, long non-coding RNA. (from RefSeq NR_131012)
RefSeq Summary (NR_131012): This gene produces a long non-coding RNA (lncRNA) transcribed from the multiple endocrine neoplasia locus. This lncRNA is retained in the nucleus where it forms the core structural component of the paraspeckle sub-organelles. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer progression. [provided by RefSeq, Mar 2015].
Gencode Transcript: ENST00000501122.2
Gencode Gene: ENSG00000245532.11
Transcript (Including UTRs)
   Position: hg38 chr11:65,422,798-65,445,540 Size: 22,743 Total Exon Count: 1 Strand: +


Page IndexSequence and LinksPrimersCTDRNA-Seq ExpressionMicroarray Expression
Other SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:65,422,798-65,445,540)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
Entrez GeneExonPrimerGencodeHGNCLynxMalacards
OMIMPubMedBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D016604 Aflatoxin B1
  • D001564 Benzo(a)pyrene
  • C006253 pirinixic acid
  • C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D017638 Asbestos, Crocidolite
  • D002945 Cisplatin
  • D003300 Copper
  • D003375 Coumestrol
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 298.72 RPKM in Thyroid
Total median expression: 4995.96 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  EF177379 - Homo sapiens nuclear enriched abundant transcript 1 (NEAT1) mRNA, complete sequence.
GQ859162 - Homo sapiens MEN beta, complete sequence.
AK026198 - Homo sapiens cDNA: FLJ22545 fis, clone HSI00239.
LF213679 - JP 2014500723-A/21182: Polycomb-Associated Non-Coding RNAs.
MA449256 - JP 2018138019-A/21182: Polycomb-Associated Non-Coding RNAs.
U60873 - Human clone 137308 mRNA, partial cds.
BX647603 - Homo sapiens mRNA; cDNA DKFZp686L01105 (from clone DKFZp686L01105).
DL491392 - Novel nucleic acids.
DL490020 - Novel nucleic acids.
AK027191 - Homo sapiens cDNA: FLJ23538 fis, clone LNG08010, highly similar to BETA2 Human MEN1 region clone epsilon/beta mRNA.
DL491828 - Novel nucleic acids.
JD026368 - Sequence 7392 from Patent EP1572962.
AF080092 - Homo sapiens trophoblast STAT utron mRNA.
AF508303 - Homo sapiens trophoblast MHC class II suppressor mRNA, complete sequence.
AL389939 - Homo sapiens EST from clone 2000376, 5' end.
JD484555 - Sequence 465579 from Patent EP1572962.
LF344443 - JP 2014500723-A/151946: Polycomb-Associated Non-Coding RNAs.
MA580020 - JP 2018138019-A/151946: Polycomb-Associated Non-Coding RNAs.
JD510722 - Sequence 491746 from Patent EP1572962.
JD548667 - Sequence 529691 from Patent EP1572962.
JD553341 - Sequence 534365 from Patent EP1572962.
JD124432 - Sequence 105456 from Patent EP1572962.
JD178908 - Sequence 159932 from Patent EP1572962.
JD548353 - Sequence 529377 from Patent EP1572962.
LF213677 - JP 2014500723-A/21180: Polycomb-Associated Non-Coding RNAs.
MA449254 - JP 2018138019-A/21180: Polycomb-Associated Non-Coding RNAs.
JD506048 - Sequence 487072 from Patent EP1572962.
JD280593 - Sequence 261617 from Patent EP1572962.
JD365644 - Sequence 346668 from Patent EP1572962.
LF213675 - JP 2014500723-A/21178: Polycomb-Associated Non-Coding RNAs.
MA449252 - JP 2018138019-A/21178: Polycomb-Associated Non-Coding RNAs.
JD180110 - Sequence 161134 from Patent EP1572962.
JD083303 - Sequence 64327 from Patent EP1572962.
AK129631 - Homo sapiens cDNA FLJ26120 fis, clone SYN00419.
JD219959 - Sequence 200983 from Patent EP1572962.
JD108090 - Sequence 89114 from Patent EP1572962.
JD245819 - Sequence 226843 from Patent EP1572962.
DL491825 - Novel nucleic acids.
DL490399 - Novel nucleic acids.
JD443682 - Sequence 424706 from Patent EP1572962.
JD372965 - Sequence 353989 from Patent EP1572962.
JD318384 - Sequence 299408 from Patent EP1572962.
JD446370 - Sequence 427394 from Patent EP1572962.
JD421915 - Sequence 402939 from Patent EP1572962.
JD533741 - Sequence 514765 from Patent EP1572962.
FV525863 - Nucleic acid controling mast cell degranulation.
HZ408690 - JP 2015528002-A/1287: CHIRAL CONTROL.
LG052024 - KR 1020150036642-A/1290: CHIRAL CONTROL.
FV524313 - Nucleic acid controling mast cell degranulation.
FW312372 - DETECTING NUCLEIC ACIDS.
FW364518 - Oligonucleotides for modulating target RNA activity.
HI964862 - Sequence 147 from Patent WO2010139812.
HI966237 - Sequence 557 from Patent WO2010139811.
HI967103 - Sequence 557 from Patent WO2010139810.
HV335387 - JP 2011097833-A/7: Using frequency of methylations of specific genes as head and neck tumor biomarker.
HV595430 - JP 2010539959-A/811: Micromirs.
HV953982 - JP 2012518421-A/894: METHODS OF DETECTING LUNG CANCER.
HW906789 - WO 2015037656-A/4: Autophagy-regulating microRNA.
HZ074468 - JP 2013535982-A/559: Single-Stranded RNAi Agents Containing an Internal, Non-Nucleic Acid Spacer.
HZ157987 - JP 2015130862-A/811: Micromirs.
HZ186831 - JP 2015146814-A/580: Oligonucleotides for modulating target RNA activity.
HZ482431 - JP 2015535430-A/2937: TERMINALLY MODIFIED RNA.
HZ792362 - JP 2016504050-A/4107: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
JA400900 - Sequence 147 from Patent WO2011080318.
JA401878 - Sequence 147 from Patent WO2011080315.
JA402885 - Sequence 147 from Patent WO2011080316.
JA405516 - Sequence 147 from Patent EP2336353.
JA426734 - Sequence 67 from Patent WO2011072177.
JA429042 - Sequence 147 from Patent WO2011095623.
JA715112 - Sequence 894 from Patent EP2401406.
JB022503 - Sequence 345 from Patent WO2013026685.
JB022851 - Sequence 105 from Patent WO2013026684.
JB074924 - Sequence 184 from Patent WO2012168448.
JB620653 - Sequence 633 from Patent WO2013063544.
JC037826 - Sequence 354 from Patent EP2643479.
JC515094 - Sequence 5347 from Patent WO2014113089.
LF160586 - JP 2016513950-A/652: Oligomers with improved off-target profile.
LP726863 - Sequence 557 from Patent EP2883966.
LP819133 - Sequence 557 from Patent EP3296406.
LP939075 - Sequence 557 from Patent EP3184651.
LQ072682 - Sequence 3006 from Patent EP2964234.
LQ441177 - Sequence 184 from Patent EP3029157.
LY405495 - KR 1020160117535-A/800: POLY OLIGOMER COMPOUND WITH BIOCLEAVABLE CONJUGATES.
LZ234188 - JP 2017184756-A/580: Oligonucleotides for modulating target RNA activity.
MA260734 - JP 2017505623-A/800: POLY OLIGOMER COMPOUND WITH BIOCLEAVABLE CONJUGATES.
MA405898 - WO 2018155427-A/672: A probe with reduced false positive binding, a method to desing the probe, and the use thereof.
MA646183 - JP 2017113010-A/4107: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MA734067 - JP 2017140048-A/2937: TERMINALLY MODIFIED RNA.
MS673302 - Sequence 105 from Patent EP3135774.
MS834001 - Sequence 147 from Patent EP3112479.
MS901872 - Sequence 345 from Patent EP3156505.
MK562403 - Homo sapiens NEAT1 lncRNA, complete sequence.
MA803236 - JP 2018183181-A/4107: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MP325470 - Sequence 17 from Patent EP3536789.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000501122.1, NR_131012, uc010rog.1, uc010rog.2, uc010rog.3
UCSC ID: ENST00000501122.2
RefSeq Accession: NR_131012

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.