Human Gene PSMC6 (ENST00000445930.7) from GENCODE V44
Description: Homo sapiens proteasome 26S subunit, ATPase 6 (PSMC6), transcript variant 3, non-coding RNA. (from RefSeq NR_158967) RefSeq Summary (NM_002806): The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, Jul 2008]. CCDS Note: The coding region has been updated to shorten the N-terminus to one that is more supported by available proteomics data. Gencode Transcript: ENST00000445930.7 Gencode Gene: ENSG00000100519.12 Transcript (Including UTRs) Position: hg38 chr14:52,707,200-52,728,590 Size: 21,391 Total Exon Count: 14 Strand: + Coding Region Position: hg38 chr14:52,707,220-52,727,617 Size: 20,398 Coding Exon Count: 14
ID:PRS10_HUMAN DESCRIPTION: RecName: Full=26S protease regulatory subunit 10B; AltName: Full=26S proteasome AAA-ATPase subunit RPT4; AltName: Full=Proteasome 26S subunit ATPase 6; AltName: Full=Proteasome subunit p42; FUNCTION: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. SUBUNIT: Found in the multi-protein complexes: the 26S proteasome (formed from the 20S proteasome and PA700), and the modulator. PA700 consists of 28 subunits arranged to form a cylinder-shaped complex by four stacked rings, each containing seven subunits. Interacts with PAAF1. INTERACTION: P62191:PSMC1; NbExp=3; IntAct=EBI-357669, EBI-357598; P17980:PSMC3; NbExp=5; IntAct=EBI-357669, EBI-359720; P43686:PSMC4; NbExp=3; IntAct=EBI-357669, EBI-743997; O00233:PSMD9; NbExp=4; IntAct=EBI-357669, EBI-750973; SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). SIMILARITY: Belongs to the AAA ATPase family. CAUTION: Alternative initiation from an upstream conserved methionine cannot be fully excluded but is not experimentally supported while initiation from the displayed methionine is supported by PubMed:17323924.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00004 - ATPase family associated with various cellular activities (AAA)
ModBase Predicted Comparative 3D Structure on P62333
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006511 ubiquitin-dependent protein catabolic process GO:0016579 protein deubiquitination GO:0030163 protein catabolic process GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:0043687 post-translational protein modification GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:1901800 positive regulation of proteasomal protein catabolic process