Human Gene TRPV1 (ENST00000572705.2) from GENCODE V44
Description: Homo sapiens transient receptor potential cation channel subfamily V member 1 (TRPV1), transcript variant 1, mRNA. (from RefSeq NM_080704) RefSeq Summary (NM_080704): Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000572705.2 Gencode Gene: ENSG00000196689.13 Transcript (Including UTRs) Position: hg38 chr17:3,565,446-3,609,411 Size: 43,966 Total Exon Count: 17 Strand: - Coding Region Position: hg38 chr17:3,566,815-3,592,350 Size: 25,536 Coding Exon Count: 15
ID:TRPV1_HUMAN DESCRIPTION: RecName: Full=Transient receptor potential cation channel subfamily V member 1; Short=TrpV1; AltName: Full=Capsaicin receptor; AltName: Full=Osm-9-like TRP channel 1; Short=OTRPC1; AltName: Full=Vanilloid receptor 1; FUNCTION: Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity). ENZYME REGULATION: Channel activity is activated via the interaction with PIRT and phosphatidylinositol 4,5-bisphosphate (PIP2). Both PIRT and PIP2 are required to activate channel activity (By similarity). SUBUNIT: Self-associates. Probably homotetramer. May also form a heteromeric channel with TRPV3. Interacts with calmodulin, PIRT, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By similarity). SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity). Cell projection, dendritic spine membrane; Multi-pass membrane protein (By similarity). TISSUE SPECIFICITY: Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level). DOMAIN: The association domain (AD) is necessary for self- association (By similarity). PTM: Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phoshphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PRKCE, PRKCM and probably PRKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity (By similarity). MISCELLANEOUS: Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine. SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily. SIMILARITY: Contains 6 ANK repeats. SEQUENCE CAUTION: Sequence=AAG43467.1; Type=Frameshift; Positions=498;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NER1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000166 nucleotide binding GO:0004888 transmembrane signaling receptor activity GO:0005216 ion channel activity GO:0005230 extracellular ligand-gated ion channel activity GO:0005231 excitatory extracellular ligand-gated ion channel activity GO:0005261 cation channel activity GO:0005262 calcium channel activity GO:0005516 calmodulin binding GO:0005524 ATP binding GO:0008324 cation transmembrane transporter activity GO:0015276 ligand-gated ion channel activity GO:0015278 calcium-release channel activity GO:0017081 chloride channel regulator activity GO:0035091 phosphatidylinositol binding GO:0042802 identical protein binding GO:0046872 metal ion binding GO:0051219 phosphoprotein binding GO:0097603 temperature-gated ion channel activity
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001659 temperature homeostasis GO:0001660 fever generation GO:0001774 microglial cell activation GO:0002024 diet induced thermogenesis GO:0002790 peptide secretion GO:0006629 lipid metabolic process GO:0006811 ion transport GO:0006816 calcium ion transport GO:0006954 inflammatory response GO:0007166 cell surface receptor signaling pathway GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007635 chemosensory behavior GO:0009268 response to pH GO:0009408 response to heat GO:0010243 response to organonitrogen compound GO:0014047 glutamate secretion GO:0014832 urinary bladder smooth muscle contraction GO:0019233 sensory perception of pain GO:0034220 ion transmembrane transport GO:0034605 cellular response to heat GO:0043065 positive regulation of apoptotic process GO:0043434 response to peptide hormone GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0048265 response to pain GO:0048266 behavioral response to pain GO:0050954 sensory perception of mechanical stimulus GO:0050955 thermoception GO:0050960 detection of temperature stimulus involved in thermoception GO:0050965 detection of temperature stimulus involved in sensory perception of pain GO:0050968 detection of chemical stimulus involved in sensory perception of pain GO:0051209 release of sequestered calcium ion into cytosol GO:0051289 protein homotetramerization GO:0055085 transmembrane transport GO:0060079 excitatory postsynaptic potential GO:0060083 smooth muscle contraction involved in micturition GO:0060454 positive regulation of gastric acid secretion GO:0070588 calcium ion transmembrane transport GO:0071312 cellular response to alkaloid GO:0071318 cellular response to ATP GO:0071345 cellular response to cytokine stimulus GO:0071356 cellular response to tumor necrosis factor GO:0071363 cellular response to growth factor stimulus GO:0071468 cellular response to acidic pH GO:0071502 cellular response to temperature stimulus GO:0090212 negative regulation of establishment of blood-brain barrier GO:0098703 calcium ion import across plasma membrane GO:1901594 response to capsazepine GO:1990090 cellular response to nerve growth factor stimulus
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