Human Gene ZNF44 (ENST00000356109.10) from GENCODE V44
  Description: Homo sapiens zinc finger protein 44 (ZNF44), transcript variant 1, mRNA. (from RefSeq NM_001164276)
Gencode Transcript: ENST00000356109.10
Gencode Gene: ENSG00000197857.16
Transcript (Including UTRs)
   Position: hg38 chr19:12,271,808-12,294,883 Size: 23,076 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr19:12,272,407-12,294,694 Size: 22,288 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:12,271,808-12,294,883)mRNA (may differ from genome)Protein (663 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGencode
GeneCardsHGNCHPRDLynxMalacardsMGI
neXtProtOMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZNF44_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 44; AltName: Full=Gonadotropin-inducible ovary transcription repressor 2; Short=GIOT-2; AltName: Full=Zinc finger protein 55; AltName: Full=Zinc finger protein 58; AltName: Full=Zinc finger protein KOX7;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 17 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.
SEQUENCE CAUTION: Sequence=CAA34357.1; Type=Frameshift; Positions=Several;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ZNF44
Diseases sorted by gene-association score: split hand-foot malformation 1 (7), enamel erosion (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.57 RPKM in Testis
Total median expression: 137.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -67.80189-0.359 Picture PostScript Text
3' UTR -169.90599-0.284 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF01352 - KRAB box
PF00096 - Zinc finger, C2H2 type

ModBase Predicted Comparative 3D Structure on P15621
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC032246 - Homo sapiens zinc finger protein 44, mRNA (cDNA clone IMAGE:5202234).
KJ902616 - Synthetic construct Homo sapiens clone ccsbBroadEn_12010 ZNF44 gene, encodes complete protein.
BC136502 - Homo sapiens zinc finger protein 44, mRNA (cDNA clone MGC:168114 IMAGE:9020491), complete cds.
AB021642 - Homo sapiens GIOT-2 mRNA for gonadotropin inducible transcription repressor-2, complete cds.
AK297528 - Homo sapiens cDNA FLJ58588 complete cds, highly similar to Zinc finger protein 44.
X16281 - Human mRNA for zinc finger protein (clone 431).
JD032199 - Sequence 13223 from Patent EP1572962.
X52338 - Human Kox7 mRNA for zinc finger protein, partial.
JD314816 - Sequence 295840 from Patent EP1572962.
JD314817 - Sequence 295841 from Patent EP1572962.
JD328287 - Sequence 309311 from Patent EP1572962.
AF024706 - Homo sapiens clone L3-4 zinc finger protein mRNA, partial cds.
BC001868 - Homo sapiens zinc finger protein 44, mRNA (cDNA clone IMAGE:3544853).
KJ902617 - Synthetic construct Homo sapiens clone ccsbBroadEn_12011 ZNF44 gene, encodes complete protein.
JD393286 - Sequence 374310 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DML9, B9EGJ5, B9ZVM2, ENST00000356109.1, ENST00000356109.2, ENST00000356109.3, ENST00000356109.4, ENST00000356109.5, ENST00000356109.6, ENST00000356109.7, ENST00000356109.8, ENST00000356109.9, GIOT2, KOX7, NM_001164276, P15621, P17018, Q9ULZ7, uc010xmj.1, uc010xmj.2, uc010xmj.3, uc010xmj.4, ZNF44_HUMAN, ZNF55, ZNF58
UCSC ID: ENST00000356109.10
RefSeq Accession: NM_001164276
Protein: P15621 (aka ZNF44_HUMAN or ZN44_HUMAN)
CCDS: CCDS54223.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.