Human Gene MSGN1 (ENST00000281047.4) from GENCODE V44
Description: Homo sapiens mesogenin 1 (MSGN1), mRNA. (from RefSeq NM_001105569)
Gencode Transcript: ENST00000281047.4
Gencode Gene: ENSG00000151379.4
Transcript (Including UTRs)
Position: hg38 chr2:17,816,460-17,817,798 Size: 1,339 Total Exon Count: 1 Strand: +
Coding Region
Position: hg38 chr2:17,816,519-17,817,100 Size: 582 Coding Exon Count: 1
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: MSGN1_HUMAN
DESCRIPTION: RecName: Full=Mesogenin-1; AltName: Full=Paraxial mesoderm-specific mesogenin1; AltName: Full=pMesogenin1; Short=pMsgn1;
FUNCTION: Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity).SUBCELLULAR LOCATION: Nucleus (Potential).SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011598 - HLH_dom
Pfam Domains: PF00010 - Helix-loop-helix DNA-binding domain
ModBase Predicted Comparative 3D Structure on A6NI15
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0046983 protein dimerization activity
Biological Process: GO:0001707 mesoderm formation
GO:0001756 somitogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007275 multicellular organism development
GO:0007379 segment specification
GO:0009880 embryonic pattern specification
GO:0030154 cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component: GO:0005634 nucleus
Descriptions from all associated GenBank mRNAs
BC172301 - Synthetic construct Homo sapiens clone IMAGE:100068995, MGC:199006 mesogenin 1 (MSGN1) mRNA, encodes complete protein.
Other Names for This Gene
Alternate Gene Symbols: A6NI15, ENST00000281047.1, ENST00000281047.2, ENST00000281047.3, MSGN1_HUMAN, NM_001105569, uc010yjt.1, uc010yjt.2, uc010yjt.3, uc010yjt.4UCSC ID: ENST00000281047.4RefSeq Accession: NM_001105569
Protein: A6NI15
(aka MSGN1_HUMAN)
CCDS: CCDS42657.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.