Human Gene SLC1A4 (ENST00000234256.4) from GENCODE V44
Description: Homo sapiens solute carrier family 1 member 4 (SLC1A4), transcript variant 1, mRNA. (from RefSeq NM_003038) RefSeq Summary (NM_003038): The protein encoded by this gene is a sodium-dependent neutral amino acid transporter for alanine, serine, cysteine, and threonine. Defects in this gene have been associated with developmental delay, microcephaly, and intellectual disability. [provided by RefSeq, Jan 2017]. Gencode Transcript: ENST00000234256.4 Gencode Gene: ENSG00000115902.11 Transcript (Including UTRs) Position: hg38 chr2:64,989,399-65,023,865 Size: 34,467 Total Exon Count: 8 Strand: + Coding Region Position: hg38 chr2:64,989,644-65,021,146 Size: 31,503 Coding Exon Count: 8
ID:SATT_HUMAN DESCRIPTION: RecName: Full=Neutral amino acid transporter A; AltName: Full=Alanine/serine/cysteine/threonine transporter 1; Short=ASCT-1; AltName: Full=SATT; AltName: Full=Solute carrier family 1 member 4; FUNCTION: Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. TISSUE SPECIFICITY: Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined. SIMILARITY: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A4 subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00375 - Sodium:dicarboxylate symporter family
ModBase Predicted Comparative 3D Structure on P43007
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK295687 - Homo sapiens cDNA FLJ52500 complete cds, highly similar to Neutral amino acid transporter A. AK298472 - Homo sapiens cDNA FLJ53154 complete cds, highly similar to Neutral amino acid transporter A. AK315986 - Homo sapiens cDNA, FLJ78885 complete cds, highly similar to Neutral amino acid transporter A. AK313052 - Homo sapiens cDNA, FLJ93528, highly similar to Homo sapiens solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 (SLC1A4), mRNA. AK223486 - Homo sapiens mRNA for solute carrier family 1, member 4 variant, clone: FCC119F11. BC072423 - Homo sapiens solute carrier family 1 (glutamate/neutral amino acid transporter), member 4, mRNA (cDNA clone MGC:90209 IMAGE:6186177), complete cds. L14595 - Human alanine/serine/cysteine/threonine transporter (ASCT1) mRNA, complete cds. BC026216 - Homo sapiens solute carrier family 1 (glutamate/neutral amino acid transporter), member 4, mRNA (cDNA clone MGC:21344 IMAGE:4420405), complete cds. L19444 - Homo sapiens neutral amino acid transporter (SATT) mRNA, complete cds. AB026689 - Homo sapiens mRNA for hASCT1, complete cds. DQ891127 - Synthetic construct clone IMAGE:100003757; FLH169550.01X; RZPDo839D0796D solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 (SLC1A4) gene, encodes complete protein. DQ894306 - Synthetic construct Homo sapiens clone IMAGE:100008766; FLH169546.01L; RZPDo839D0795D solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 (SLC1A4) gene, encodes complete protein. AK126636 - Homo sapiens cDNA FLJ44678 fis, clone BRACE3009392, highly similar to Neutral amino acid transporter A. JD254180 - Sequence 235204 from Patent EP1572962. JD439622 - Sequence 420646 from Patent EP1572962. JD101006 - Sequence 82030 from Patent EP1572962. JD280667 - Sequence 261691 from Patent EP1572962. AL833067 - Homo sapiens mRNA; cDNA DKFZp451L0215 (from clone DKFZp451L0215). JD233241 - Sequence 214265 from Patent EP1572962. JD383672 - Sequence 364696 from Patent EP1572962. JD474141 - Sequence 455165 from Patent EP1572962. JD390154 - Sequence 371178 from Patent EP1572962. JD126010 - Sequence 107034 from Patent EP1572962. JD490130 - Sequence 471154 from Patent EP1572962. JD161496 - Sequence 142520 from Patent EP1572962. JD086164 - Sequence 67188 from Patent EP1572962. JD313513 - Sequence 294537 from Patent EP1572962. JD220818 - Sequence 201842 from Patent EP1572962. JD082520 - Sequence 63544 from Patent EP1572962. BC007350 - Homo sapiens solute carrier family 1 (glutamate/neutral amino acid transporter), member 4, mRNA (cDNA clone IMAGE:3614401), partial cds. JD562058 - Sequence 543082 from Patent EP1572962. JD370951 - Sequence 351975 from Patent EP1572962. JD377312 - Sequence 358336 from Patent EP1572962. JD550984 - Sequence 532008 from Patent EP1572962. JD235730 - Sequence 216754 from Patent EP1572962. JD338015 - Sequence 319039 from Patent EP1572962. JD287482 - Sequence 268506 from Patent EP1572962. JD207478 - Sequence 188502 from Patent EP1572962. JD283545 - Sequence 264569 from Patent EP1572962. JD042639 - Sequence 23663 from Patent EP1572962. JD525984 - Sequence 507008 from Patent EP1572962. JD511955 - Sequence 492979 from Patent EP1572962. JD288748 - Sequence 269772 from Patent EP1572962. JD097173 - Sequence 78197 from Patent EP1572962. JD524073 - Sequence 505097 from Patent EP1572962. JD232572 - Sequence 213596 from Patent EP1572962. JD535963 - Sequence 516987 from Patent EP1572962. JD560235 - Sequence 541259 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P43007 (Reactome details) participates in the following event(s):
R-HSA-352347 SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine R-HSA-352354 SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine R-HSA-352364 SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine R-HSA-352371 SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine R-HSA-352230 Amino acid transport across the plasma membrane R-HSA-425374 Amino acid and oligopeptide SLC transporters R-HSA-425393 Metabolism of nitrogenous molecules R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules