Human Gene DQX1 (ENST00000404568.4) from GENCODE V44
  Description: Homo sapiens DEAQ-box RNA dependent ATPase 1 (DQX1), mRNA. (from RefSeq NM_133637)
Gencode Transcript: ENST00000404568.4
Gencode Gene: ENSG00000144045.14
Transcript (Including UTRs)
   Position: hg38 chr2:74,518,131-74,526,231 Size: 8,101 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg38 chr2:74,518,446-74,525,729 Size: 7,284 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:74,518,131-74,526,231)mRNA (may differ from genome)Protein (717 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=ATP-dependent RNA helicase DQX1; EC=; AltName: Full=DEAQ box polypeptide 1;
CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Contains 1 helicase ATP-binding domain.
SIMILARITY: Contains 1 helicase C-terminal domain.

-  Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.23 RPKM in Small Intestine - Terminal Ileum
Total median expression: 44.47 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -34.20115-0.297 Picture PostScript Text
3' UTR -81.10315-0.257 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011709 - DUF1605
IPR007502 - Helicase-assoc_dom
IPR014001 - Helicase_ATP-bd
IPR001650 - Helicase_C

Pfam Domains:
PF04408 - Helicase associated domain (HA2)
PF07717 - Oligonucleotide/oligosaccharide-binding (OB)-fold

ModBase Predicted Comparative 3D Structure on Q8TE96
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0004004 ATP-dependent RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity

Biological Process:
GO:0000398 mRNA splicing, via spliceosome

Cellular Component:
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm

-  Descriptions from all associated GenBank mRNAs
  BC033238 - Homo sapiens DEAQ box polypeptide 1 (RNA-dependent ATPase), mRNA (cDNA clone IMAGE:5428942), partial cds.
AK074337 - Homo sapiens cDNA FLJ23757 fis, clone HEP17946, highly similar to Mus musculus DEAQ RNA-dependent ATPase DQX1 mRNA.
JD054231 - Sequence 35255 from Patent EP1572962.
JD055789 - Sequence 36813 from Patent EP1572962.
JD491570 - Sequence 472594 from Patent EP1572962.
JD081705 - Sequence 62729 from Patent EP1572962.
BC075018 - Homo sapiens DEAQ box RNA-dependent ATPase 1, mRNA (cDNA clone MGC:104000 IMAGE:30915408), complete cds.
KJ903949 - Synthetic construct Homo sapiens clone ccsbBroadEn_13343 DQX1 gene, encodes complete protein.
AK092420 - Homo sapiens cDNA FLJ35101 fis, clone PLACE6006418.
AX747536 - Sequence 1061 from Patent EP1308459.
JD192211 - Sequence 173235 from Patent EP1572962.
JD369253 - Sequence 350277 from Patent EP1572962.
JD166383 - Sequence 147407 from Patent EP1572962.
JD361493 - Sequence 342517 from Patent EP1572962.
JD336445 - Sequence 317469 from Patent EP1572962.
JD146977 - Sequence 128001 from Patent EP1572962.
JD103726 - Sequence 84750 from Patent EP1572962.
JD134909 - Sequence 115933 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: DQX1_HUMAN, ENST00000404568.1, ENST00000404568.2, ENST00000404568.3, NM_133637, Q6B017, Q8NAM8, Q8TE96, uc010yrw.1, uc010yrw.2, uc010yrw.3, uc010yrw.4
UCSC ID: ENST00000404568.4
RefSeq Accession: NM_133637
Protein: Q8TE96 (aka DQX1_HUMAN)
CCDS: CCDS1949.2

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.