Human Gene IL36A (ENST00000259211.7) from GENCODE V44
Description: Homo sapiens interleukin 36 alpha (IL36A), mRNA. (from RefSeq NM_014440) RefSeq Summary (NM_014440): The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients. [provided by RefSeq, Nov 2015]. Gencode Transcript: ENST00000259211.7 Gencode Gene: ENSG00000136694.9 Transcript (Including UTRs) Position: hg38 chr2:113,005,459-113,008,044 Size: 2,586 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr2:113,005,872-113,008,044 Size: 2,173 Coding Exon Count: 4
ID:IL36A_HUMAN DESCRIPTION: RecName: Full=Interleukin-36 alpha; AltName: Full=FIL1 epsilon; AltName: Full=Interleukin-1 epsilon; Short=IL-1 epsilon; AltName: Full=Interleukin-1 family member 6; Short=IL-1F6; SUBCELLULAR LOCATION: Secreted (Potential). TISSUE SPECIFICITY: Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. MISCELLANEOUS: Binding analysis failed to detect interaction with multiple IL1R family members. SIMILARITY: Belongs to the IL-1 family. WEB RESOURCE: Name=Wikipedia; Note=Interleukin-1 entry; URL="http://en.wikipedia.org/wiki/Interleukin_1"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il1f6/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UHA7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
