Human Gene TAS2R60 (ENST00000332690.1) from GENCODE V44
Description: Homo sapiens taste 2 receptor member 60 (TAS2R60), mRNA. (from RefSeq NM_177437) RefSeq Summary (NM_177437): This gene encodes a member of the bitter taste receptor family which belong to the G protein-coupled receptor superfamily and are predominantly expressed in taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a seven-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered together with eight other taste receptor genes on chromosome 7. [provided by RefSeq, Jul 2017]. Gencode Transcript: ENST00000332690.1 Gencode Gene: ENSG00000185899.1 Transcript (Including UTRs) Position: hg38 chr7:143,443,453-143,444,409 Size: 957 Total Exon Count: 1 Strand: + Coding Region Position: hg38 chr7:143,443,453-143,444,409 Size: 957 Coding Exon Count: 1
ID:T2R60_HUMAN DESCRIPTION: RecName: Full=Taste receptor type 2 member 60; Short=T2R60; AltName: Full=Taste receptor type 2 member 56; Short=T2R56; FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli. SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
Pfam Domains: PF05296 - Taste receptor protein (TAS2R)
ModBase Predicted Comparative 3D Structure on P59551
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0050896 response to stimulus GO:0050909 sensory perception of taste GO:0050913 sensory perception of bitter taste GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste