Human Gene GBX1 (ENST00000297537.5) from GENCODE V44
  Description: Homo sapiens gastrulation brain homeobox 1 (GBX1), mRNA. (from RefSeq NM_001098834)
Gencode Transcript: ENST00000297537.5
Gencode Gene: ENSG00000164900.5
Transcript (Including UTRs)
   Position: hg38 chr7:151,148,009-151,167,694 Size: 19,686 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr7:151,148,589-151,167,548 Size: 18,960 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:151,148,009-151,167,694)mRNA (may differ from genome)Protein (363 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
HPRDMGIneXtProtOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GBX1_HUMAN
DESCRIPTION: RecName: Full=Homeobox protein GBX-1; AltName: Full=Gastrulation and brain-specific homeobox protein 1;
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Contains 1 homeobox DNA-binding domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.81 RPKM in Testis
Total median expression: 7.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -87.70146-0.601 Picture PostScript Text
3' UTR -213.20580-0.368 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017970 - Homeobox_CS
IPR020479 - Homeobox_metazoa
IPR001356 - Homeodomain
IPR009057 - Homeodomain-like

Pfam Domains:
PF00046 - Homeobox domain

ModBase Predicted Comparative 3D Structure on Q14549
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein SequenceProtein SequenceProtein Sequence  
AlignmentAlignmentAlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007628 adult walking behavior
GO:0019230 proprioception
GO:0021522 spinal cord motor neuron differentiation
GO:0048663 neuron fate commitment
GO:0097374 sensory neuron axon guidance

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  LF206785 - JP 2014500723-A/14288: Polycomb-Associated Non-Coding RNAs.
MA442362 - JP 2018138019-A/14288: Polycomb-Associated Non-Coding RNAs.
BC160003 - Synthetic construct Homo sapiens clone IMAGE:100063939, MGC:193118 gastrulation brain homeobox 1 (GBX1) mRNA, encodes complete protein.
JD056235 - Sequence 37259 from Patent EP1572962.
JD458584 - Sequence 439608 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000297537.1, ENST00000297537.2, ENST00000297537.3, ENST00000297537.4, GBX1_HUMAN, NM_001098834, Q14549, uc011kvg.1, uc011kvg.2, uc011kvg.3, uc011kvg.4
UCSC ID: ENST00000297537.5
RefSeq Accession: NM_001098834
Protein: Q14549 (aka GBX1_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.