Human Gene TREX2 (ENST00000370231.3) from GENCODE V44
Description: Homo sapiens three prime repair exonuclease 2 (TREX2), mRNA. (from RefSeq NM_080701) RefSeq Summary (NM_080701): This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. [provided by RefSeq, Nov 2012]. Gencode Transcript: ENST00000370231.3 Gencode Gene: ENSG00000183479.13 Transcript (Including UTRs) Position: hg38 chrX:153,444,473-153,446,056 Size: 1,584 Total Exon Count: 2 Strand: - Coding Region Position: hg38 chrX:153,444,720-153,445,430 Size: 711 Coding Exon Count: 1
ID:TREX2_HUMAN DESCRIPTION: RecName: Full=Three prime repair exonuclease 2; EC=3.1.11.2; AltName: Full=3'-5' exonuclease TREX2; FUNCTION: Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNA repair. CATALYTIC ACTIVITY: Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates. COFACTOR: Magnesium. Required for activity. Substitution with Mn(2+) results in partial activity. BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7.5-8.0; SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Detected in heart, breast, prostate, skeletal muscle, testis, uterus, bone marrow, colon, small intestine, stomach and thymus. SIMILARITY: Belongs to the exonuclease superfamily. TREX family. CAUTION: The gene for this protein is either identical to or adjacent to that of UCHL5IP. Most mRNAs that encode UCHL5IP also include the N-terminal part of TREX2. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/trex2/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BQ50
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006259 DNA metabolic process GO:0006281 DNA repair GO:0006974 cellular response to DNA damage stimulus GO:0090305 nucleic acid phosphodiester bond hydrolysis
US Server
