Human Gene TTN (ENST00000342992.11) from GENCODE V44
  Description: Homo sapiens titin (TTN), transcript variant N2-A, mRNA. (from RefSeq NM_133378)
RefSeq Summary (NM_133378): This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012].
Gencode Transcript: ENST00000342992.11
Gencode Gene: ENSG00000155657.29
Transcript (Including UTRs)
   Position: hg38 chr2:178,525,989-178,807,423 Size: 281,435 Total Exon Count: 312 Strand: -
Coding Region
   Position: hg38 chr2:178,527,012-178,804,642 Size: 277,631 Coding Exon Count: 311 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesGeneReviewsMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:178,525,989-178,807,423)mRNA (may differ from genome)Protein (33423 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGencode
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Titin; EC=; AltName: Full=Connectin; AltName: Full=Rhabdomyosarcoma antigen MU-RMS-40.14;
FUNCTION: Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Magnesium.
ENZYME REGULATION: Full activation of the protein kinase domain requires both phosphorylation of Tyr-32341, preventing it from blocking the catalytic aspartate residue, and binding of Ca/CALM to the C-terminal regulatory tail of the molecule which results in ATP binding to the kinase.
SUBUNIT: Interacts with MYOM1, MYOM2, tropomyosin and myosin. Interacts with actin, primarily via the PEVK domains and with MYPN (By similarity). Interacts with FHL2, NEB, CRYAB, LMNA/lamin-A and LMNB/lamin-B. Interacts with TCAP/telethonin and/or ANK1 isoform Mu17/ank1.5, via the first two N-terminal immunoglobulin domains. Interacts with TRIM63 and TRIM55, through several domains including immunoglobulin domains 141 and 142. Interacts with ANKRD1, ANKRD2 and ANKRD23, via the region between immunoglobulin domains 77 and 78 and interacts with CAPN3, via immunoglobulin domain 79. Interacts with NBR1 through the protein kinase domain. Interacts with CALM/calmodulin. Isoform 8 interacts with OBSCN isoform 3. Interacts with CMYA5.
INTERACTION: Self; NbExp=16; IntAct=EBI-681210, EBI-681210; P35609:ACTN2; NbExp=7; IntAct=EBI-681210, EBI-77797; P20807:CAPN3; NbExp=3; IntAct=EBI-681210, EBI-5655000; O75953:DNAJB5; NbExp=4; IntAct=EBI-681210, EBI-5655937; O75923:DYSF; NbExp=17; IntAct=EBI-681210, EBI-2799016; P06733:ENO1; NbExp=3; IntAct=EBI-681210, EBI-353877; Q14324:MYBPC2; NbExp=14; IntAct=EBI-681210, EBI-5653200; Q13203:MYBPH; NbExp=3; IntAct=EBI-681210, EBI-5655165; P54296:MYOM2; NbExp=2; IntAct=EBI-681210, EBI-5357134; Q5VST9:OBSCN; NbExp=4; IntAct=EBI-681210, EBI-941850; Q96CV9:OPTN; NbExp=2; IntAct=EBI-681210, EBI-748974; O15273:TCAP; NbExp=4; IntAct=EBI-681210, EBI-954089;
SUBCELLULAR LOCATION: Cytoplasm (Probable). Nucleus.
TISSUE SPECIFICITY: Isoform 3, isoform 7 and isoform 8 are expressed in cardiac muscle. Isoform 4 is expressed in vertebrate skeletal muscle. Isoform 6 is expressed in cardiac tissues.
DOMAIN: ZIS1 and ZIS5 regions contain multiple SPXR consensus sites for ERK- and CDK-like protein kinases as well as multiple SP motifs. ZIS1 could adopt a closed conformation which would block the TCAP-binding site.
DOMAIN: The PEVK region may serve as an entropic spring of a chain of structural folds and may also be an interaction site to other myofilament proteins to form interfilament connectivity in the sarcomere.
PTM: Autophosphorylated (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
DISEASE: Defects in TTN are the cause of hereditary myopathy with early respiratory failure (HMERF) [MIM:603689]; also known as Edstrom myopathy. HMERF is an autosomal dominant, adult-onset myopathy with early respiratory muscle involvement.
DISEASE: Defects in TTN are the cause of familial hypertrophic cardiomyopathy type 9 (CMH9) [MIM:613765]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
DISEASE: Defects in TTN are the cause of cardiomyopathy dilated type 1G (CMD1G) [MIM:604145]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
DISEASE: Defects in TTN are the cause of tardive tibial muscular dystrophy (TMD) [MIM:600334]; also known as Udd myopathy. TMD is an autosomal dominant, late-onset distal myopathy. Muscle weakness and atrophy are usually confined to the anterior compartment of the lower leg, in particular the tibialis anterior muscle. Clinical symptoms usually occur at age 35-45 years or much later.
DISEASE: Defects in TTN are the cause of limb-girdle muscular dystrophy type 2J (LGMD2J) [MIM:608807]. LGMD2J is an autosomal recessive degenerative myopathy characterized by progressive weakness of the pelvic and shoulder girdle muscles. Severe disability is observed within 20 years of onset.
DISEASE: Defects in TTN are the cause of early-onset myopathy with fatal cardiomyopathy (EOMFC) [MIM:611705]. Early-onset myopathies are inherited muscle disorders that manifest typically from birth or infancy with hypotonia, muscle weakness, and delayed motor development. EOMFC is a titinopathy that, in contrast with the previously described examples, involves both heart and skeletal muscle, has a congenital onset, and is purely recessive. This phenotype is due to homozygous out-of-frame TTN deletions, which lead to a total absence of titin's C-terminal end from striated muscles and to secondary CAPN3 depletion.
MISCELLANEOUS: In some isoforms, after the PEVK repeat region there is a long PEVK duplicated region. On account of this region, it has been very difficult to sequence the whole protein. The length of this region (ranging from 183 to 2174 residues), may be a key elastic element of titin.
SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
SIMILARITY: Contains 132 fibronectin type-III domains.
SIMILARITY: Contains 152 Ig-like (immunoglobulin-like) domains.
SIMILARITY: Contains 19 Kelch repeats.
SIMILARITY: Contains 1 protein kinase domain.
SIMILARITY: Contains 17 RCC1 repeats.
SIMILARITY: Contains 14 TPR repeats.
SIMILARITY: Contains 15 WD repeats.
SEQUENCE CAUTION: Sequence=AAH58824.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 553; Sequence=AAH70170.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 627; Sequence=CAA62188.1; Type=Frameshift; Positions=17036, 17043; Sequence=CAD12455.1; Type=Frameshift; Positions=17036, 17043;
WEB RESOURCE: Name=GeneReviews; URL="";
WEB RESOURCE: Name=Wikipedia; Note=Titin entry; URL="";

-  Primer design for this transcript

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-  MalaCards Disease Associations
  MalaCards Gene Search: TTN
Diseases sorted by gene-association score: tibial muscular dystrophy, tardive* (1650), myopathy, proximal, with early respiratory muscle involvement* (1650), muscular dystrophy, limb-girdle, type 2j* (1367), salih myopathy* (1350), cardiomyopathy, dilated, 1g* (1247), cardiomyopathy, familial hypertrophic, 9* (1229), childhood-onset progressive contractures-limb-girdle weakness-muscle dystrophy syndrome* (350), myopathy, centronuclear, autosomal recessive* (247), autosomal recessive limb-girdle muscular dystrophy* (207), muscular dystrophy, rigid spine, 1* (204), myopathy* (198), dilated cardiomyopathy* (182), familial isolated arrhythmogenic ventricular dysplasia, right dominant form* (157), familial isolated arrhythmogenic ventricular dysplasia, biventricular form* (157), familial isolated arrhythmogenic ventricular dysplasia, left dominant form* (157), familial isolated dilated cardiomyopathy* (101), ttn-related dilated cardiomyopathy* (100), ttn-related familial hypertrophic cardiomyopathy* (100), cardiomyopathy, familial hypertrophic* (43), respiratory failure (32), cardiomyopathy (23), myasthenia gravis (16), reducing body myopathy (16), cortical thymoma (16), thymoma (16), morvan's fibrillary chorea (13), rippling muscle disease (11), myopathy, myofibrillar, 3 (11), dendritic cell thymoma (11), granulomatous myositis (10), lambert-eaton myasthenic syndrome (10), myositis (10), peripartum cardiomyopathy (10), muscular dystrophy, limb-girdle, type 2a (10), autosomal recessive limb-girdle muscular dystrophy type 2h (10), centronuclear myopathy (9), muscular dystrophy-dystroglycanopathy , type c, 5 (9), distal muscular dystrophy (9), muscular dystrophy (8), muscle disorders (8), lung large cell carcinoma (8), rhabdomyosarcoma (8), asphyxia neonatorum (7), neuromuscular junction disease (6), restrictive cardiomyopathy (6), newborn respiratory distress syndrome (6), cardiomyopathy, hypertrophic, 4 (6), myofibrillar myopathy (6), intrinsic cardiomyopathy (5), heart disease (5), myopathy, spheroid body (4), duchenne muscular dystrophy (4), arrhythmogenic right ventricular cardiomyopathy (3), neuromuscular disease (3), primary cutaneous amyloidosis (1), left ventricular noncompaction (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
  • C518576 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate
  • C547126 AZM551248
  • D000082 Acetaminophen
  • D000643 Ammonium Chloride
  • D001564 Benzo(a)pyrene
  • D019274 Botulinum Toxins, Type A
  • D002101 Cacodylic Acid
  • D002118 Calcium
  • D002922 Ciguatoxins
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 204.71 RPKM in Muscle - Skeletal
Total median expression: 315.09 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -89.50225-0.398 Picture PostScript Text
3' UTR -256.101023-0.250 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022682 - Calpain_domain_III
IPR003961 - Fibronectin_type3
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013098 - Ig_I-set
IPR003599 - Ig_sub
IPR003598 - Ig_sub2
IPR011009 - Kinase-like_dom
IPR004168 - PPAK_motif
IPR000719 - Prot_kinase_cat_dom
IPR012337 - RNaseH-like_dom
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR015129 - Titin_Z
IPR008266 - Tyr_kinase_AS

Pfam Domains:
PF00041 - Fibronectin type III domain
PF07679 - Immunoglobulin I-set domain
PF00069 - Protein kinase domain
PF02818 - PPAK motif
PF09042 - Titin Z

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1BPV - NMR MuPIT 1G1C - X-ray MuPIT 1NCT - NMR MuPIT 1NCU - NMR MuPIT 1TIT - NMR MuPIT 1TIU - NMR MuPIT 1TKI - X-ray MuPIT 1TNM - NMR MuPIT 1TNN - NMR MuPIT 1WAA - X-ray MuPIT 1YA5 - X-ray MuPIT 2A38 - X-ray MuPIT 2BK8 - X-ray MuPIT 2F8V - X-ray MuPIT 2ILL - X-ray MuPIT 2J8H - X-ray MuPIT 2J8O - X-ray MuPIT 2NZI - X-ray MuPIT 2RQ8 - NMR MuPIT 2WP3 - X-ray MuPIT 2WWK - X-ray MuPIT 2WWM - X-ray MuPIT 2Y9R - X-ray MuPIT 3B43 - X-ray 3KNB - X-ray MuPIT 3LCY - X-ray MuPIT 3LPW - X-ray MuPIT 3PUC - X-ray MuPIT 3Q5O - X-ray MuPIT 3QP3 - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q8WZ42
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein Sequence     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0002020 protease binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008307 structural constituent of muscle
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0031433 telethonin binding
GO:0042802 identical protein binding
GO:0042805 actinin binding
GO:0043621 protein self-association
GO:0046872 metal ion binding
GO:0051015 actin filament binding
GO:0051371 muscle alpha-actinin binding
GO:0097493 structural molecule activity conferring elasticity

Biological Process:
GO:0002576 platelet degranulation
GO:0003300 cardiac muscle hypertrophy
GO:0006468 protein phosphorylation
GO:0006936 muscle contraction
GO:0006941 striated muscle contraction
GO:0007076 mitotic chromosome condensation
GO:0010628 positive regulation of gene expression
GO:0010737 protein kinase A signaling
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030049 muscle filament sliding
GO:0030240 skeletal muscle thin filament assembly
GO:0030241 skeletal muscle myosin thick filament assembly
GO:0035995 detection of muscle stretch
GO:0045214 sarcomere organization
GO:0045859 regulation of protein kinase activity
GO:0048739 cardiac muscle fiber development
GO:0048769 sarcomerogenesis
GO:0050714 positive regulation of protein secretion
GO:0050790 regulation of catalytic activity
GO:0051592 response to calcium ion
GO:0055003 cardiac myofibril assembly
GO:0055008 cardiac muscle tissue morphogenesis
GO:0060048 cardiac muscle contraction

Cellular Component:
GO:0000794 condensed nuclear chromosome
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005859 muscle myosin complex
GO:0005865 striated muscle thin filament
GO:0030018 Z disc
GO:0031430 M band
GO:0031674 I band
GO:0070062 extracellular exosome

-  Descriptions from all associated GenBank mRNAs
  AK129531 - Homo sapiens cDNA FLJ26020 fis, clone PCD01884, highly similar to Homo sapiens titin (TTN), transcript variant N2-B.
X90568 - H.sapiens mRNA for titin protein (clone hh1-hh54).
X90569 - H.sapiens mRNA for titin protein (clone hsk1-hsk19).
AF525413 - Homo sapiens cardiac titin N2BA isoform (TTN) mRNA, partial cds.
EF212153 - Homo sapiens cellular titin isoform PEVK variant 1 mRNA, partial cds, alternatively spliced.
EF212154 - Homo sapiens cellular titin isoform PEVK variant 2 mRNA, partial cds, alternatively spliced.
BC107797 - Homo sapiens titin, mRNA (cDNA clone IMAGE:4271154), partial cds.
AL713647 - Homo sapiens mRNA; cDNA DKFZp451A172 (from clone DKFZp451A172).
X69490 - H.sapiens mRNA for titin.
JD334263 - Sequence 315287 from Patent EP1572962.
JD186984 - Sequence 168008 from Patent EP1572962.
JD046483 - Sequence 27507 from Patent EP1572962.
JD503548 - Sequence 484572 from Patent EP1572962.
JD455968 - Sequence 436992 from Patent EP1572962.
JD044540 - Sequence 25564 from Patent EP1572962.
JD259449 - Sequence 240473 from Patent EP1572962.
JD067093 - Sequence 48117 from Patent EP1572962.
JD491063 - Sequence 472087 from Patent EP1572962.
JD301058 - Sequence 282082 from Patent EP1572962.
JD083960 - Sequence 64984 from Patent EP1572962.
X64697 - H.sapiens mRNA titin (subclone C37).
JX424570 - Homo sapiens Titin mRNA, partial cds.
AK091732 - Homo sapiens cDNA FLJ34413 fis, clone HEART2002717, highly similar to H.sapiens mRNA for titin protein (clone hh1-hh54).
AK129856 - Homo sapiens cDNA FLJ26346 fis, clone HRT04038, highly similar to Homo sapiens titin (TTN), transcript variant N2-B.
X64698 - H.sapiens mRNA titin (subclone C26/C18).
AK096883 - Homo sapiens cDNA FLJ39564 fis, clone SKMUS2001199, highly similar to H.sapiens mRNA for titin protein3.
DL492529 - Novel nucleic acids.
DL490998 - Novel nucleic acids.
EU428784 - Homo sapiens titin (TTN) mRNA, partial cds.
DQ248309 - Homo sapiens rhabdomyosarcoma antigen MU-RMS-40.14 mRNA, partial cds.
AK129919 - Homo sapiens cDNA FLJ26409 fis, clone HRT09310, highly similar to Homo sapiens titin (TTN), transcript variant N2-B.
AF321609 - Homo sapiens titin (TTN) mRNA, partial cds.
EF212156 - Homo sapiens cellular titin isoform PEVK variant 4 mRNA, partial cds, alternatively spliced.
EF212155 - Homo sapiens cellular titin isoform PEVK variant 3 mRNA, partial cds, alternatively spliced.
BC017983 - Homo sapiens cDNA clone IMAGE:4245816, containing frame-shift errors.
BC030823 - Homo sapiens titin, mRNA (cDNA clone IMAGE:4246573).
BC026297 - Homo sapiens titin, mRNA (cDNA clone IMAGE:4271100).
AK125056 - Homo sapiens cDNA FLJ43066 fis, clone BRTHA3008608, highly similar to Homo sapiens partial TTN gene for titin.
X83270 - H.sapiens mRNA for titin, partial CDS.
AK056602 - Homo sapiens cDNA FLJ32040 fis, clone NTONG2000858, highly similar to H.sapiens mRNA for titin protein.
X98114 - Homo sapiens mRNA for cardiac titin, clone ZisS.
X98115 - H.sapiens mRNA for cardiac titin, clone ZisL.
BC070170 - Homo sapiens titin, mRNA (cDNA clone IMAGE:4271838), partial cds.
BC058824 - Homo sapiens titin, mRNA (cDNA clone IMAGE:4288662), partial cds.
BC013396 - Homo sapiens titin, mRNA (cDNA clone IMAGE:3532073), complete cds.
BC029400 - Homo sapiens titin, mRNA (cDNA clone IMAGE:4288214), with apparent retained intron.
JD184639 - Sequence 165663 from Patent EP1572962.
JD328078 - Sequence 309102 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8WZ42 (Reactome details) participates in the following event(s):

R-HSA-482772 Release of platelet cytosolic components
R-HSA-390595 Calcium Binds Troponin-C
R-HSA-390597 Release Of ADP From Myosin
R-HSA-390593 ATP Hydrolysis By Myosin
R-HSA-390598 Myosin Binds ATP
R-HSA-114608 Platelet degranulation
R-HSA-390522 Striated Muscle Contraction
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
R-HSA-397014 Muscle contraction
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-109582 Hemostasis

-  Other Names for This Gene
  Alternate Gene Symbols: A6NKB1, E7EQE6, E7ET18, ENST00000342992.1, ENST00000342992.10, ENST00000342992.2, ENST00000342992.3, ENST00000342992.4, ENST00000342992.5, ENST00000342992.6, ENST00000342992.7, ENST00000342992.8, ENST00000342992.9, NM_133378, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q4ZG20, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ42, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9, TITIN_HUMAN, uc021vsy.1, uc021vsy.2, uc021vsy.3, uc021vsy.4, uc021vsy.5
UCSC ID: ENST00000342992.11
RefSeq Accession: NM_133378
Protein: Q8WZ42 (aka TITIN_HUMAN)

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene TTN:
dcm-ov (Dilated Cardiomyopathy Overview)
hmerf (Hereditary Myopathy with Early Respiratory Failure)
hyper-card (Hypertrophic Cardiomyopathy Overview)
salih-myo (Salih Myopathy)
udd (Udd Distal Myopathy - Tibial Muscular Dystrophy)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.