Human Gene TGIF2 (ENST00000373874.6) from GENCODE V44
Description: Homo sapiens TGFB induced factor homeobox 2 (TGIF2), transcript variant 3, mRNA. (from RefSeq NM_001199513) RefSeq Summary (NM_001199514): The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010]. Gencode Transcript: ENST00000373874.6 Gencode Gene: ENSG00000118707.11 Transcript (Including UTRs) Position: hg38 chr20:36,573,488-36,593,950 Size: 20,463 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr20:36,578,775-36,591,431 Size: 12,657 Coding Exon Count: 2
ID:TGIF2_HUMAN DESCRIPTION: RecName: Full=Homeobox protein TGIF2; AltName: Full=5'-TG-3'-interacting factor 2; AltName: Full=TGF-beta-induced transcription factor 2; Short=TGFB-induced factor 2; FUNCTION: Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. SUBUNIT: Interacts with the transcriptional modulator SMAD3 and the histone deacetylase HDAC1. SUBCELLULAR LOCATION: Nucleus. Note=Excluded from nucleoli. TISSUE SPECIFICITY: Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate. PTM: The C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway. MISCELLANEOUS: TGIF2 is amplified and overexpressed in several ovarian cancer cell lines. SIMILARITY: Belongs to the TALE/TGIF homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9GZN2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0010470 regulation of gastrulation GO:0038092 nodal signaling pathway GO:0045666 positive regulation of neuron differentiation GO:0060041 retina development in camera-type eye
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