Human Gene THBS4 (ENST00000350881.6) from GENCODE V44
Description: Homo sapiens thrombospondin 4 (THBS4), transcript variant 1, mRNA. (from RefSeq NM_003248) RefSeq Summary (NM_003248): The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. Gencode Transcript: ENST00000350881.6 Gencode Gene: ENSG00000113296.14 Transcript (Including UTRs) Position: hg38 chr5:80,035,348-80,083,287 Size: 47,940 Total Exon Count: 22 Strand: + Coding Region Position: hg38 chr5:80,035,538-80,083,141 Size: 47,604 Coding Exon Count: 22
ID:TSP4_HUMAN DESCRIPTION: RecName: Full=Thrombospondin-4; Flags: Precursor; FUNCTION: Acts as an extracellular mitogen and stimulates early erythroid progenitors proliferation in presence of EPO. Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen. SUBUNIT: Homopentamer; disulfide-linked. Interacts with PTBP3. SIMILARITY: Belongs to the thrombospondin family. SIMILARITY: Contains 4 EGF-like domains. SIMILARITY: Contains 1 laminin G-like domain. SIMILARITY: Contains 1 TSP C-terminal (TSPC) domain. SIMILARITY: Contains 8 TSP type-3 repeats. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/thbs4/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF11598 - Cartilage oligomeric matrix protein PF07645 - Calcium-binding EGF domain PF02412 - Thrombospondin type 3 repeat PF05735 - Thrombospondin C-terminal region
ModBase Predicted Comparative 3D Structure on P35443
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.