Human Gene LINC-ROR (ENST00000553704.3) from GENCODE V44
  Description: Homo sapiens long intergenic non-protein coding RNA, regulator of reprogramming (LINC-ROR), transcript variant 1, long non-coding RNA. (from RefSeq NR_048536)
RefSeq Summary (NR_048536): This gene produces a long non-coding RNA that regulates the reprogramming of pluripotent stem cells. This RNA suppresses induction of tumor protein p53 after DNA damage. It is thought to act as a sponge for microRNAs that regulate stem cell factors POU class 5 homeobox 1, Nanog, and SRY-box 2. This RNA may also have a extracellular role in modulating response to hypoxia in hepatocellular cancer cells. Expression of this transcript is associated with tumor progression and epithelial to mesenchymal transition and metastasis. [provided by RefSeq, Dec 2017].
Gencode Transcript: ENST00000553704.3
Gencode Gene: ENSG00000258609.3
Transcript (Including UTRs)
   Position: hg38 chr18:57,054,558-57,072,119 Size: 17,562 Total Exon Count: 4 Strand: -


Page IndexSequence and LinksPrimersMalaCardsRNA-Seq ExpressionMicroarray Expression
Other SpeciesmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr18:57,054,558-57,072,119)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
Entrez GeneExonPrimerGencodeHGNCLynxMalacards
OMIMPubMedBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: LINC-ROR
Diseases sorted by gene-association score: juvenile astrocytoma (2), chronic intestinal vascular insufficiency (1)

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.04 RPKM in Testis
Total median expression: 0.08 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  HQ315778 - Homo sapiens lincRNA-ST8SIA3, complete sequence.
LC027884 - Homo sapiens transcribed RNA, LINC-ROR, complete sequence, variant 14.
LC027885 - Homo sapiens transcribed RNA, LINC-ROR, complete sequence, variant 8.
LC027886 - Homo sapiens transcribed RNA, LINC-ROR, complete sequence, variant 9.
LC027887 - Homo sapiens transcribed RNA, LINC-ROR, complete sequence, variant 10.
LC027888 - Homo sapiens transcribed RNA, LINC-ROR, complete sequence, variant 11.
LC027890 - Homo sapiens transcribed RNA, LINC-ROR, complete sequence, variant 13.
AB844430 - Homo sapiens transcribed RNA, LINC-ROR, complete sequence, variant 2.
AB844431 - Homo sapiens transcribed RNA, LINC-ROR, complete sequence, variant 3.
AB844432 - Homo sapiens transcribed RNA, LINC-ROR, complete sequence, variant 4.
AB844433 - Homo sapiens transcribed RNA, LINC-ROR, complete sequence, variant 5.
AB932951 - Homo sapiens transcribed RNA, LINC-ROR, complete sequence, variant 7.
AB908956 - Homo sapiens transcribed RNA, LINC-ROR, complete sequence, variant 6.
DQ582447 - Homo sapiens piRNA piR-32559, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000553704.1, ENST00000553704.2, NR_048536, uc031ril.1, uc031ril.2, uc031ril.3
UCSC ID: ENST00000553704.3
RefSeq Accession: NR_048536

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.