Human Gene GRIPAP1 (ENST00000376423.8) from GENCODE V44
Description: Homo sapiens GRIP1 associated protein 1 (GRIPAP1), mRNA. (from RefSeq NM_020137) RefSeq Summary (NM_020137): This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function. [provided by RefSeq, Aug 2013]. Gencode Transcript: ENST00000376423.8 Gencode Gene: ENSG00000068400.14 Transcript (Including UTRs) Position: hg38 chrX:48,973,723-49,002,264 Size: 28,542 Total Exon Count: 26 Strand: - Coding Region Position: hg38 chrX:48,974,193-49,002,229 Size: 28,037 Coding Exon Count: 26
ID:GRAP1_HUMAN DESCRIPTION: RecName: Full=GRIP1-associated protein 1; Short=GRASP-1; SUBUNIT: Interacts with GRIP1, GRIP2 and AMPA receptors (By similarity). SUBCELLULAR LOCATION: Early endosome. PTM: Proteolytically cleaved by caspase-3 (By similarity). MISCELLANEOUS: Antibodies against GRIPAP1 have been found in sera of a patient who developed Raynaud's syndrome and telangiectasias.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q4V328
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0008150 biological_process GO:0015031 protein transport GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane GO:1905244 regulation of modification of synaptic structure
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