Human Gene DNASE1L1 (ENST00000393638.5) from GENCODE V44
Description: Homo sapiens deoxyribonuclease 1 like 1 (DNASE1L1), transcript variant 4, mRNA. (from RefSeq NM_001009934) RefSeq Summary (NM_001009934): This gene encodes a deoxyribonuclease protein that shows high sequence similarity to DNase I. The encoded protein is localized to the endoplasmic reticulum and modified by N-linked glycosylation. Alternate transcriptional splice variants encoding the same protein have been observed. [provided by RefSeq, Jan 2015]. Gencode Transcript: ENST00000393638.5 Gencode Gene: ENSG00000013563.14 Transcript (Including UTRs) Position: hg38 chrX:154,401,238-154,412,090 Size: 10,853 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chrX:154,402,707-154,405,568 Size: 2,862 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF03372 - Endonuclease/Exonuclease/phosphatase family
ModBase Predicted Comparative 3D Structure on P49184
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006259 DNA metabolic process GO:0006308 DNA catabolic process GO:0043312 neutrophil degranulation GO:0090305 nucleic acid phosphodiester bond hydrolysis