Human Gene CDKN2C (ENST00000262662.5) from GENCODE V44
Description: cyclin dependent kinase inhibitor 2C (from HGNC CDKN2C) RefSeq Summary (NM_001262): The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000262662.5 Gencode Gene: ENSG00000123080.12 Transcript (Including UTRs) Position: hg38 chr1:50,960,745-50,974,633 Size: 13,889 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr1:50,970,369-50,974,270 Size: 3,902 Coding Exon Count: 2
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6ICV4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
