Human Gene NPTXR (ENST00000333039.4) from GENCODE V44
  Description: Homo sapiens neuronal pentraxin receptor (NPTXR), mRNA. (from RefSeq NM_014293)
RefSeq Summary (NM_014293): This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for mouse and human, based on strong sequence conservation amongst these species. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Gencode Transcript: ENST00000333039.4
Gencode Gene: ENSG00000221890.6
Transcript (Including UTRs)
   Position: hg38 chr22:38,818,452-38,844,028 Size: 25,577 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr22:38,822,609-38,843,858 Size: 21,250 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:38,818,452-38,844,028)mRNA (may differ from genome)Protein (500 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NPTXR_HUMAN
DESCRIPTION: RecName: Full=Neuronal pentraxin receptor;
COFACTOR: Binds 2 calcium ions per subunit (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Potential).
SIMILARITY: Contains 1 pentaxin domain.
SEQUENCE CAUTION: Sequence=CAA15430.3; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NPTXR
Diseases sorted by gene-association score: acromesomelic dysplasia, maroteaux type (2), acromesomelic dysplasia (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 93.49 RPKM in Brain - Anterior cingulate cortex (BA24)
Total median expression: 719.66 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -85.40170-0.502 Picture PostScript Text
3' UTR -1609.704157-0.387 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008985 - ConA-like_lec_gl_sf
IPR013320 - ConA-like_subgrp
IPR001759 - Pentaxin

Pfam Domains:
PF00354 - Pentaxin family

ModBase Predicted Comparative 3D Structure on O95502
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0046872 metal ion binding

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AL161974 - Homo sapiens mRNA; cDNA DKFZp761M2013 (from clone DKFZp761M2013).
BC043606 - Homo sapiens cDNA clone IMAGE:5735114.
AF052163 - Homo sapiens clone 24456 mRNA sequence.
AL162057 - Homo sapiens mRNA; cDNA DKFZp761N0524 (from clone DKFZp761N0524).
JD233349 - Sequence 214373 from Patent EP1572962.
JD431639 - Sequence 412663 from Patent EP1572962.
JD130469 - Sequence 111493 from Patent EP1572962.
JD278035 - Sequence 259059 from Patent EP1572962.
JD111908 - Sequence 92932 from Patent EP1572962.
JD363836 - Sequence 344860 from Patent EP1572962.
JD513195 - Sequence 494219 from Patent EP1572962.
JD457360 - Sequence 438384 from Patent EP1572962.
JD439581 - Sequence 420605 from Patent EP1572962.
JD403687 - Sequence 384711 from Patent EP1572962.
JD394273 - Sequence 375297 from Patent EP1572962.
JD493640 - Sequence 474664 from Patent EP1572962.
JD523902 - Sequence 504926 from Patent EP1572962.
JD259147 - Sequence 240171 from Patent EP1572962.
JD156643 - Sequence 137667 from Patent EP1572962.
JD430897 - Sequence 411921 from Patent EP1572962.
JD215955 - Sequence 196979 from Patent EP1572962.
JD401466 - Sequence 382490 from Patent EP1572962.
JD363153 - Sequence 344177 from Patent EP1572962.
JD382785 - Sequence 363809 from Patent EP1572962.
JD260828 - Sequence 241852 from Patent EP1572962.
JD117836 - Sequence 98860 from Patent EP1572962.
JD163534 - Sequence 144558 from Patent EP1572962.
JD092447 - Sequence 73471 from Patent EP1572962.
JD115646 - Sequence 96670 from Patent EP1572962.
JD465637 - Sequence 446661 from Patent EP1572962.
JD213508 - Sequence 194532 from Patent EP1572962.
JD394311 - Sequence 375335 from Patent EP1572962.
JD077589 - Sequence 58613 from Patent EP1572962.
JD218674 - Sequence 199698 from Patent EP1572962.
JD104284 - Sequence 85308 from Patent EP1572962.
JD391427 - Sequence 372451 from Patent EP1572962.
JD081278 - Sequence 62302 from Patent EP1572962.
JD422266 - Sequence 403290 from Patent EP1572962.
JD279280 - Sequence 260304 from Patent EP1572962.
JD037507 - Sequence 18531 from Patent EP1572962.
JD551593 - Sequence 532617 from Patent EP1572962.
JD513144 - Sequence 494168 from Patent EP1572962.
JD122259 - Sequence 103283 from Patent EP1572962.
JD513143 - Sequence 494167 from Patent EP1572962.
JD045284 - Sequence 26308 from Patent EP1572962.
JD132954 - Sequence 113978 from Patent EP1572962.
JD332682 - Sequence 313706 from Patent EP1572962.
JD431543 - Sequence 412567 from Patent EP1572962.
JD495291 - Sequence 476315 from Patent EP1572962.
JD339417 - Sequence 320441 from Patent EP1572962.
JD551001 - Sequence 532025 from Patent EP1572962.
JD274985 - Sequence 256009 from Patent EP1572962.
JD362729 - Sequence 343753 from Patent EP1572962.
JD052223 - Sequence 33247 from Patent EP1572962.
JD355640 - Sequence 336664 from Patent EP1572962.
JD383506 - Sequence 364530 from Patent EP1572962.
JD400314 - Sequence 381338 from Patent EP1572962.
JD485674 - Sequence 466698 from Patent EP1572962.
JD516597 - Sequence 497621 from Patent EP1572962.
JD399868 - Sequence 380892 from Patent EP1572962.
JD519809 - Sequence 500833 from Patent EP1572962.
JD040489 - Sequence 21513 from Patent EP1572962.
JD332946 - Sequence 313970 from Patent EP1572962.
JD323690 - Sequence 304714 from Patent EP1572962.
JD163036 - Sequence 144060 from Patent EP1572962.
JD103907 - Sequence 84931 from Patent EP1572962.
JD264783 - Sequence 245807 from Patent EP1572962.
JD108457 - Sequence 89481 from Patent EP1572962.
JD430581 - Sequence 411605 from Patent EP1572962.
JD261677 - Sequence 242701 from Patent EP1572962.
JD259897 - Sequence 240921 from Patent EP1572962.
JD162800 - Sequence 143824 from Patent EP1572962.
JD377102 - Sequence 358126 from Patent EP1572962.
JD208859 - Sequence 189883 from Patent EP1572962.
JD159047 - Sequence 140071 from Patent EP1572962.
JD522133 - Sequence 503157 from Patent EP1572962.
JD556237 - Sequence 537261 from Patent EP1572962.
JD446376 - Sequence 427400 from Patent EP1572962.
JD364833 - Sequence 345857 from Patent EP1572962.
JD427019 - Sequence 408043 from Patent EP1572962.
JD181230 - Sequence 162254 from Patent EP1572962.
JD473305 - Sequence 454329 from Patent EP1572962.
JD242245 - Sequence 223269 from Patent EP1572962.
JD174257 - Sequence 155281 from Patent EP1572962.
JD214254 - Sequence 195278 from Patent EP1572962.
JD182334 - Sequence 163358 from Patent EP1572962.
JD427814 - Sequence 408838 from Patent EP1572962.
JD190311 - Sequence 171335 from Patent EP1572962.
JD103853 - Sequence 84877 from Patent EP1572962.
JD068091 - Sequence 49115 from Patent EP1572962.
JD223169 - Sequence 204193 from Patent EP1572962.
JD220596 - Sequence 201620 from Patent EP1572962.
JD130365 - Sequence 111389 from Patent EP1572962.
JD229857 - Sequence 210881 from Patent EP1572962.
JD210023 - Sequence 191047 from Patent EP1572962.
JD457099 - Sequence 438123 from Patent EP1572962.
JD432096 - Sequence 413120 from Patent EP1572962.
JD175093 - Sequence 156117 from Patent EP1572962.
JD339416 - Sequence 320440 from Patent EP1572962.
JD317893 - Sequence 298917 from Patent EP1572962.
JD438207 - Sequence 419231 from Patent EP1572962.
JD110543 - Sequence 91567 from Patent EP1572962.
JD045551 - Sequence 26575 from Patent EP1572962.
JD471768 - Sequence 452792 from Patent EP1572962.
JD329370 - Sequence 310394 from Patent EP1572962.
JD043206 - Sequence 24230 from Patent EP1572962.
JD297573 - Sequence 278597 from Patent EP1572962.
JD113524 - Sequence 94548 from Patent EP1572962.
JD147835 - Sequence 128859 from Patent EP1572962.
JD194221 - Sequence 175245 from Patent EP1572962.
JD387394 - Sequence 368418 from Patent EP1572962.
JD283576 - Sequence 264600 from Patent EP1572962.
JD354302 - Sequence 335326 from Patent EP1572962.
JD365522 - Sequence 346546 from Patent EP1572962.
JD455683 - Sequence 436707 from Patent EP1572962.
JD338723 - Sequence 319747 from Patent EP1572962.
JD066328 - Sequence 47352 from Patent EP1572962.
JD153768 - Sequence 134792 from Patent EP1572962.
JD255635 - Sequence 236659 from Patent EP1572962.
JD195353 - Sequence 176377 from Patent EP1572962.
JD116484 - Sequence 97508 from Patent EP1572962.
JD343820 - Sequence 324844 from Patent EP1572962.
BC148601 - Synthetic construct Homo sapiens clone IMAGE:100015637, MGC:183139 neuronal pentraxin receptor (NPTXR) mRNA, encodes complete protein.
BC153027 - Synthetic construct Homo sapiens clone IMAGE:100016404, MGC:184254 neuronal pentraxin receptor (NPTXR) mRNA, encodes complete protein.
AB527378 - Synthetic construct DNA, clone: pF1KE0384, Homo sapiens NPTXR gene for neuronal pentraxin receptor, without stop codon, in Flexi system.
JD129222 - Sequence 110246 from Patent EP1572962.
JD399377 - Sequence 380401 from Patent EP1572962.
JD142379 - Sequence 123403 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000333039.1, ENST00000333039.2, ENST00000333039.3, NM_014293, NPTXR_HUMAN, O95502, uc062eix.1, uc062eix.2, uc062eix.3
UCSC ID: ENST00000333039.4
RefSeq Accession: NM_014293
Protein: O95502 (aka NPTXR_HUMAN or NPXR_HUMAN)
CCDS: CCDS33647.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.