Human Gene MT-ND6 (ENST00000361681.2) from GENCODE V44
  Description: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 (from HGNC MT-ND6)
Gencode Transcript: ENST00000361681.2
Gencode Gene: ENSG00000198695.2
Transcript (Including UTRs)
   Position: hg38 chrM:14,149-14,673 Size: 525 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg38 chrM:14,149-14,673 Size: 525 Coding Exon Count: 1 

Page IndexSequence and LinksPrimersMalaCardsRNA-Seq ExpressionMicroarray Expression
Other SpeciesPathwaysOther NamesGeneReviewsMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrM:14,149-14,673)mRNA (may differ from genome)Protein (175 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
EnsemblExonPrimerGencodeGeneCardsHGNCMalacards
MGIPubMedUniProtKB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MT-ND6
Diseases sorted by gene-association score: leber optic atrophy* (1180), mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes* (754), leber hereditary optic neuropathy with dystonia* (741), oxyphilic adenoma* (403), leigh syndrome* (187), mitochondrial dna-associated leigh syndrome and narp* (141), melas, mt-nd6-related* (100), mitochondrial complex i deficiency* (86), encephalomyopathy (21), mitochondrial disorders* (19), mitochondrial encephalomyopathy (18), parkinson disease 6, early onset (14), kearns-sayre syndrome (12), optic nerve disease (9), lactic acidosis (7), cranial nerve disease (7), neuropathy (7), cortical blindness (7), dystonia (7), mitochondrial metabolism disease (4), optic atrophy plus syndrome (4), peripheral nervous system disease (1)
* = Manually curated disease association

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8844.44 RPKM in Heart - Left Ventricle
Total median expression: 189946.23 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-3781 - aerobic respiration I (cytochrome c)

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000361681.1, U5Z977, uc064xpm.1
UCSC ID: ENST00000361681.2

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene MT-ND6:
lhon (Leber Hereditary Optic Neuropathy)
melas (MELAS)
mt-overview (Primary Mitochondrial Disorders Overview)
narp (Mitochondrial DNA-Associated Leigh Syndrome and NARP)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.