Description: Homo sapiens monoamine oxidase A (MAOA), transcript variant 1, mRNA. (from RefSeq NM_000240) RefSeq Summary (NM_000240): This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]. Gencode Transcript: ENST00000338702.4 Gencode Gene: ENSG00000189221.10 Transcript (Including UTRs) Position: hg38 chrX:43,656,299-43,746,817 Size: 90,519 Total Exon Count: 15 Strand: + Coding Region Position: hg38 chrX:43,656,342-43,744,513 Size: 88,172 Coding Exon Count: 15
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q53YE7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.