Human Gene MAOA (ENST00000338702.4)
  Description: Homo sapiens monoamine oxidase A (MAOA), transcript variant 1, mRNA. (from RefSeq NM_000240)
RefSeq Summary (NM_000240): This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012].
Gencode Transcript: ENST00000338702.4
Gencode Gene: ENSG00000189221.10
Transcript (Including UTRs)
   Position: hg38 chrX:43,656,299-43,746,817 Size: 90,519 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg38 chrX:43,656,342-43,744,513 Size: 88,172 Coding Exon Count: 15 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrX:43,656,299-43,746,817)mRNA (may differ from genome)Protein (527 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  MalaCards Disease Associations
  MalaCards Gene Search: MAOA
Diseases sorted by gene-association score: brunner syndrome* (1121), maoa-related behavior disorders* (100), antisocial personality disorder (35), social phobia (33), conduct disorder (31), endogenous depression (29), personality disorder (20), borderline personality disorder (20), paranoid schizophrenia (17), phobic disorder (17), atypical depressive disorder (17), dysthymic disorder (16), serotonin syndrome (14), anxiety disorder (14), mood disorder (14), norrie disease (13), agoraphobia (13), chronic fatigue syndrome (11), generalized anxiety disorder (11), oppositional defiant disorder (10), hepatic encephalopathy (10), panic disorder (10), postpartum depression (10), phobia, specific (9), avoidant personality disorder (9), pathological gambling (9), dependent personality disorder (8), obsessive-compulsive disorder (8), post-traumatic stress disorder (8), exhibitionism (8), sudden infant death syndrome (8), substance abuse (8), retinitis pigmentosa-50 (8), bulimia nervosa (7), alcohol dependence (7), attention deficit-hyperactivity disorder (7), substance dependence (7), paraphilia disorder (7), mental depression (6), migraine with or without aura 1 (6), dystonia-1, torsion (6), kleptomania (5), early-onset schizophrenia (5), nicotine dependence, protection against (5), mediastinal malignant lymphoma (5), mediastinal gray zone lymphoma (5), pure autonomic failure (3), parkinson disease, late-onset (3), autism spectrum disorder (2), schizophrenia (2), disease of mental health (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 111.16 RPKM in Small Intestine - Terminal Ileum
Total median expression: 1572.91 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -8.1043-0.188 Picture PostScript Text
3' UTR -613.202304-0.266 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002937 - Amino_oxidase
IPR001613 - Flavin_amine_oxidase

Pfam Domains:
PF01593 - Flavin containing amine oxidoreductase

ModBase Predicted Comparative 3D Structure on Q53YE7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008131 primary amine oxidase activity
GO:0016491 oxidoreductase activity

Biological Process:
GO:0042420 dopamine catabolic process
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005739 mitochondrion

-  Descriptions from all associated GenBank mRNAs
  KJ897163 - Synthetic construct Homo sapiens clone ccsbBroadEn_06557 MAOA gene, encodes complete protein.
BC044787 - Homo sapiens monoamine oxidase A, mRNA (cDNA clone MGC:42558 IMAGE:4824582), complete cds.
AK223499 - Homo sapiens mRNA for monoamine oxidase A variant, clone: FCC121A07.
M68840 - Human monoamine oxidase A (MAOA) mRNA, complete cds.
AK293926 - Homo sapiens cDNA FLJ61220 complete cds, highly similar to Amine oxidase (flavin-containing) A (EC
AK291769 - Homo sapiens cDNA FLJ76052 complete cds, highly similar to Homo sapiens monoamine oxidase A (MAOA), nuclear gene encoding mitochondrial protein, mRNA.
BC008064 - Homo sapiens monoamine oxidase A, mRNA (cDNA clone MGC:2288 IMAGE:2990003), complete cds.
M69226 - Human monoamine oxidase (MAOA) mRNA, complete cds.
CU675911 - Synthetic construct Homo sapiens gateway clone IMAGE:100020324 5' read MAOA mRNA.
DQ890676 - Synthetic construct clone IMAGE:100003306; FLH165001.01X; RZPDo839E07158D monoamine oxidase A (MAOA) gene, encodes complete protein.
DQ893857 - Synthetic construct Homo sapiens clone IMAGE:100008317; FLH164997.01L; RZPDo839E07157D monoamine oxidase A (MAOA) gene, encodes complete protein.
BT006651 - Homo sapiens monoamine oxidase A mRNA, complete cds.
AK123241 - Homo sapiens cDNA FLJ41247 fis, clone BRAMY2032777.
X17192 - Human mRNA for placental monoamine oxidase A (MAO A) (EC

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00260 - Glycine, serine and threonine metabolism
hsa00330 - Arginine and proline metabolism
hsa00340 - Histidine metabolism
hsa00350 - Tyrosine metabolism
hsa00360 - Phenylalanine metabolism
hsa00380 - Tryptophan metabolism
hsa00982 - Drug metabolism - cytochrome P450
hsa01100 - Metabolic pathways

BioCyc Knowledge Library
PWY-0 - putrescine degradation III
PWY-6313 - serotonin degradation
PWY-6342 - noradrenaline and adrenaline degradation
PWY-6399 - melatonin degradation II
PWY-6402 - superpathway of melatonin degradation
PWY66-401 - superpathway of tryptophan utilization
PWY6666-2 - dopamine degradation

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000338702.1, ENST00000338702.2, ENST00000338702.3, hCG_16826, NM_000240, Q53YE7, Q53YE7_HUMAN, RP1-201D17__B.2-001, uc004dfy.1, uc004dfy.2, uc004dfy.3, uc004dfy.4, uc004dfy.5, uc004dfy.6
UCSC ID: ENST00000338702.4
RefSeq Accession: NM_000240
Protein: Q53YE7 CCDS: CCDS14260.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.