Human Gene TSHB (ENST00000256592.3) from GENCODE V44
Description: Homo sapiens thyroid stimulating hormone subunit beta (TSHB), transcript variant 1, mRNA. (from RefSeq NM_000549) RefSeq Summary (NM_000549): The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]. Gencode Transcript: ENST00000256592.3 Gencode Gene: ENSG00000134200.4 Transcript (Including UTRs) Position: hg38 chr1:115,029,826-115,034,302 Size: 4,477 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr1:115,033,363-115,034,227 Size: 865 Coding Exon Count: 2
ID:TSHB_HUMAN DESCRIPTION: RecName: Full=Thyrotropin subunit beta; AltName: Full=Thyroid-stimulating hormone subunit beta; Short=TSH-B; Short=TSH-beta; AltName: Full=Thyrotropin beta chain; AltName: INN=Thyrotropin alfa; Flags: Precursor; FUNCTION: Indispensable for the control of thyroid structure and metabolism. SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin. SUBCELLULAR LOCATION: Secreted. PHARMACEUTICAL: Available under the name Thyrogen (Genzyme). Used in combination with other tests to detect recurring or leftover thyroid cancer cells in patients with a history of certain types of thyroid cancer. SIMILARITY: Belongs to the glycoprotein hormones subunit beta family. WEB RESOURCE: Name=Thyrogen; Note=Clinical information on Thyrogen; URL="http://www.thyrogen.com/home/thy_home.asp"; WEB RESOURCE: Name=Wikipedia; Note=Thyroid-stimulating hormone entry; URL="http://en.wikipedia.org/wiki/Thyroid-stimulating_hormone";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P01222
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.