Human Gene BCL2 (ENST00000398117.1) Description and Page Index
  Description: Homo sapiens BCL2 apoptosis regulator (BCL2), transcript variant alpha, mRNA. (from RefSeq NM_000633)
RefSeq Summary (NM_000633): This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Gencode Transcript: ENST00000398117.1
Gencode Gene: ENSG00000171791.13
Transcript (Including UTRs)
   Position: hg38 chr18:63,123,346-63,320,128 Size: 196,783 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr18:63,128,625-63,318,666 Size: 190,042 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr18:63,123,346-63,320,128)mRNA (may differ from genome)Protein (239 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: BCL2_HUMAN
DESCRIPTION: RecName: Full=Apoptosis regulator Bcl-2;
FUNCTION: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
SUBUNIT: Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity (By similarity). Interacts with EI24 (By similarity). Also interacts with APAF1, BBC3, BCL2L1, BNIPL, MRPL41 and TP53BP2. Binding to FKBP8 seems to target BCL2 to the mitochondria and probably interferes with the binding of BCL2 to its targets. Interacts with BAG1 in an ATP-dependent manner. Interacts with RAF1 (the 'Ser- 338' and 'Ser-339' phosphorylated form). Interacts (via the BH4 domain) with EGLN3; the interaction prevents the formation of the BAX-BCL2 complex and inhibits the anti-apoptotic activity of BCL2. Interacts with G0S2; this interaction also prevents the formation of the anti-apoptotic BAX-BCL2 complex.
INTERACTION: Self; NbExp=3; IntAct=EBI-77694, EBI-77694; Q92934:BAD; NbExp=5; IntAct=EBI-77694, EBI-700771; Q61337:Bad (xeno); NbExp=6; IntAct=EBI-77694, EBI-400328; Q07812:BAX; NbExp=8; IntAct=EBI-77694, EBI-516580; Q9BXH1:BBC3; NbExp=5; IntAct=EBI-77694, EBI-519884; P51572:BCAP31; NbExp=2; IntAct=EBI-77694, EBI-77683; O43521:BCL2L11; NbExp=4; IntAct=EBI-77694, EBI-526406; O43521-1:BCL2L11; NbExp=3; IntAct=EBI-77694, EBI-526416; O43521-2:BCL2L11; NbExp=4; IntAct=EBI-77694, EBI-526420; Q14457:BECN1; NbExp=3; IntAct=EBI-77694, EBI-949378; P55957:BID; NbExp=8; IntAct=EBI-77694, EBI-519672; Q13323:BIK; NbExp=3; IntAct=EBI-77694, EBI-700794; Q91ZE9:Bmf (xeno); NbExp=2; IntAct=EBI-77694, EBI-708032; O60238:BNIP3L; NbExp=2; IntAct=EBI-77694, EBI-849893; Q9C000:NLRP1; NbExp=12; IntAct=EBI-77694, EBI-1220518; P22736:NR4A1; NbExp=7; IntAct=EBI-77694, EBI-721550; Q13794:PMAIP1; NbExp=3; IntAct=EBI-77694, EBI-707392; O15304:SIVA1; NbExp=2; IntAct=EBI-77694, EBI-520756; P04637:TP53; NbExp=3; IntAct=EBI-77694, EBI-366083;
SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
TISSUE SPECIFICITY: Expressed in a variety of tissues.
DOMAIN: The BH4 motif is required for anti-apoptotic activity and for interaction with RAF1 and EGLN3.
PTM: Phosphorylation/dephosphorylation on Ser-70 regulates anti- apoptotic activity. Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases. Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-87, wich stimulates starvation-induced autophagy. Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity).
PTM: Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity, causes the release of cytochrome c into the cytosol promoting further caspase activity.
PTM: Monoubiquitinated by PARK2, leading to increase its stability.
DISEASE: Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
SIMILARITY: Belongs to the Bcl-2 family.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BCL2ID49.html";
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/bcl2/";
WEB RESOURCE: Name=Wikipedia; Note=Bcl-2 entry; URL="http://en.wikipedia.org/wiki/Bcl-2";

-  MalaCards Disease Associations
  MalaCards Gene Search: BCL2
Diseases sorted by gene-association score: follicular lymphoma 1* (175), lymphoma (46), follicular lymphoma (39), benign mammary dysplasia (18), intravascular large b-cell lymphoma* (18), lymphoma, small cleaved-cell, diffuse (16), kashin-beck disease (13), nodal marginal zone b-cell lymphoma (13), cervical carcinosarcoma (12), hidradenocarcinoma (12), lymphoma, non-hodgkin (12), heart tumor (12), chronic lymphocytic leukemia (12), mantle cell lymphoma (11), salivary gland adenoid cystic carcinoma (11), hodgkin lymphoma (11), diffuse large b-cell lymphoma (10), malignant teratoma (10), ovarian serous cystadenocarcinoma (10), b-cell lymphomas (9), keratocystic odontogenic tumor (9), central pontine myelinolysis (8), primary central nervous system lymphoma (8), ectopic thymus (7), cartilage-hair hypoplasia (7), extramedullary plasmacytoma (7), benign metastasizing leiomyoma (7), mannosidosis, beta (7), histiocytic sarcoma (7), epithelial malignant thymoma (7), thymus gland disease (7), soft tissue sarcoma (6), waldenstrom macroglobulinemia (6), alk-negative anaplastic large cell lymphoma (6), marginal zone b-cell lymphoma (6), dendritic cell thymoma (6), gastric lymphoma (6), head injury (6), human herpesvirus 8 (6), lung cancer (6), osteochondroma (5), fuchs' endothelial dystrophy (5), breast cancer (5), colorectal cancer (5), syphilis (5), lymphosarcoma (5), chondromyxoid fibroma (5), retinal ischemia (5), li-fraumeni syndrome (4), clear cell renal cell carcinoma (4), prostate cancer (4), ischemia (3), endometrial cancer (3), differentiated thyroid carcinoma (3), lateral sclerosis (2), nasopharyngeal carcinoma (2), leukemia, acute lymphoblastic (2), adamantinoma of long bones (2), ovarian cancer, somatic (2), inflammatory myofibroblastic tumor (2), lymphoma, malt, somatic (1), nervous system cancer (1), gastric cancer, somatic (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 27.67 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 247.42 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -543.001462-0.371 Picture PostScript Text
3' UTR -1490.205279-0.282 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013278 - Apop_reg_Bcl2
IPR002475 - Bcl2-like
IPR004725 - Bcl2/BclX
IPR020717 - Bcl2_BH1_motif_CS
IPR020726 - Bcl2_BH2_motif_CS
IPR020728 - Bcl2_BH3_motif_CS
IPR003093 - Bcl2_BH4
IPR020731 - Bcl2_BH4_motif_CS
IPR026298 - Blc2_fam

Pfam Domains:
PF00452 - Apoptosis regulator proteins, Bcl-2 family
PF02180 - Bcl-2 homology region 4

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1G5M
- NMR MuPIT

1GJH
- NMR MuPIT

1YSW
- NMR MuPIT
To conserve bandwidth, only the images from the first 3 structures are shown.
2O21 - NMR MuPIT 2O22 - NMR MuPIT 2O2F - NMR MuPIT
2W3L - X-ray MuPIT 2XA0 - X-ray MuPIT 4AQ3 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P10415
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0002020 protease binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0015267 channel activity
GO:0016248 channel inhibitor activity
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
GO:0051434 BH3 domain binding
GO:0051721 protein phosphatase 2A binding

Biological Process:
GO:0000209 protein polyubiquitination
GO:0000902 cell morphogenesis
GO:0001503 ossification
GO:0001541 ovarian follicle development
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001662 behavioral fear response
GO:0001776 leukocyte homeostasis
GO:0001782 B cell homeostasis
GO:0001822 kidney development
GO:0001836 release of cytochrome c from mitochondria
GO:0001952 regulation of cell-matrix adhesion
GO:0002260 lymphocyte homeostasis
GO:0002320 lymphoid progenitor cell differentiation
GO:0002326 B cell lineage commitment
GO:0002360 T cell lineage commitment
GO:0002520 immune system development
GO:0002931 response to ischemia
GO:0003014 renal system process
GO:0006470 protein dephosphorylation
GO:0006582 melanin metabolic process
GO:0006808 regulation of nitrogen utilization
GO:0006874 cellular calcium ion homeostasis
GO:0006915 apoptotic process
GO:0006959 humoral immune response
GO:0006974 cellular response to DNA damage stimulus
GO:0006979 response to oxidative stress
GO:0007015 actin filament organization
GO:0007409 axonogenesis
GO:0007565 female pregnancy
GO:0007569 cell aging
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008584 male gonad development
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008637 apoptotic mitochondrial changes
GO:0009314 response to radiation
GO:0009636 response to toxic substance
GO:0009791 post-embryonic development
GO:0009887 animal organ morphogenesis
GO:0010039 response to iron ion
GO:0010224 response to UV-B
GO:0010332 response to gamma radiation
GO:0010468 regulation of gene expression
GO:0010506 regulation of autophagy
GO:0010507 negative regulation of autophagy
GO:0010523 negative regulation of calcium ion transport into cytosol
GO:0010559 regulation of glycoprotein biosynthetic process
GO:0014031 mesenchymal cell development
GO:0014042 positive regulation of neuron maturation
GO:0014911 positive regulation of smooth muscle cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0021747 cochlear nucleus development
GO:0022612 gland morphogenesis
GO:0022898 regulation of transmembrane transporter activity
GO:0030097 hemopoiesis
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030279 negative regulation of ossification
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0030318 melanocyte differentiation
GO:0030336 negative regulation of cell migration
GO:0030890 positive regulation of B cell proliferation
GO:0031069 hair follicle morphogenesis
GO:0031103 axon regeneration
GO:0031647 regulation of protein stability
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032835 glomerulus development
GO:0032848 negative regulation of cellular pH reduction
GO:0032880 regulation of protein localization
GO:0033033 negative regulation of myeloid cell apoptotic process
GO:0033077 T cell differentiation in thymus
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033689 negative regulation of osteoblast proliferation
GO:0034097 response to cytokine
GO:0035094 response to nicotine
GO:0035265 organ growth
GO:0040007 growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042100 B cell proliferation
GO:0042149 cellular response to glucose starvation
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042981 regulation of apoptotic process
GO:0043029 T cell homeostasis
GO:0043066 negative regulation of apoptotic process
GO:0043067 regulation of programmed cell death
GO:0043085 positive regulation of catalytic activity
GO:0043375 CD8-positive, alpha-beta T cell lineage commitment
GO:0043473 pigmentation
GO:0043496 regulation of protein homodimerization activity
GO:0043497 regulation of protein heterodimerization activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043583 ear development
GO:0045069 regulation of viral genome replication
GO:0045636 positive regulation of melanocyte differentiation
GO:0045930 negative regulation of mitotic cell cycle
GO:0046671 negative regulation of retinal cell programmed cell death
GO:0046902 regulation of mitochondrial membrane permeability
GO:0048041 focal adhesion assembly
GO:0048066 developmental pigmentation
GO:0048070 regulation of developmental pigmentation
GO:0048087 positive regulation of developmental pigmentation
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048545 response to steroid hormone
GO:0048546 digestive tract morphogenesis
GO:0048589 developmental growth
GO:0048599 oocyte development
GO:0048743 positive regulation of skeletal muscle fiber development
GO:0048753 pigment granule organization
GO:0048873 homeostasis of number of cells within a tissue
GO:0050790 regulation of catalytic activity
GO:0050853 B cell receptor signaling pathway
GO:0051384 response to glucocorticoid
GO:0051402 neuron apoptotic process
GO:0051607 defense response to virus
GO:0051726 regulation of cell cycle
GO:0051881 regulation of mitochondrial membrane potential
GO:0051902 negative regulation of mitochondrial depolarization
GO:0051924 regulation of calcium ion transport
GO:0055085 transmembrane transport
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071310 cellular response to organic substance
GO:0071456 cellular response to hypoxia
GO:0072593 reactive oxygen species metabolic process
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0098609 cell-cell adhesion
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2000811 negative regulation of anoikis
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0031966 mitochondrial membrane
GO:0032991 macromolecular complex
GO:0043209 myelin sheath
GO:0046930 pore complex


-  Descriptions from all associated GenBank mRNAs
  M14745 - Human bcl-2 mRNA.
FW409933 - NUCLEIC ACID COMPOUNDS FOR INHIBITING BCL2 GENE EXPRESSION AND USES THEREOF.
M13994 - Human B-cell leukemia/lymphoma 2 (bcl-2) proto-oncogene mRNA encoding bcl-2-alpha protein, complete cds.
BC027258 - Homo sapiens B-cell CLL/lymphoma 2, mRNA (cDNA clone MGC:21366 IMAGE:4511027), complete cds.
X06487 - H.sapiens mRNA for bcl2-Ig fusion gene.
EU287875 - Homo sapiens B-cell leukemia/lymphoma-2-alpha protein (bcl-2) mRNA, complete cds.
DQ891470 - Synthetic construct clone IMAGE:100004100; FLH177254.01X; RZPDo839F02124D B-cell CLL/lymphoma 2 (BCL2) gene, encodes complete protein.
DQ894654 - Synthetic construct Homo sapiens clone IMAGE:100009114; FLH177251.01L; RZPDo839F02123D B-cell CLL/lymphoma 2 (BCL2) gene, encodes complete protein.
AB462959 - Synthetic construct DNA, clone: pF1KB3129, Homo sapiens BCL2 gene for B-cell CLL/lymphoma 2, without stop codon, in Flexi system.
JD285685 - Sequence 266709 from Patent EP1572962.
JD214598 - Sequence 195622 from Patent EP1572962.
JD132149 - Sequence 113173 from Patent EP1572962.
JD412542 - Sequence 393566 from Patent EP1572962.
JD436570 - Sequence 417594 from Patent EP1572962.
JD530972 - Sequence 511996 from Patent EP1572962.
JD552445 - Sequence 533469 from Patent EP1572962.
JD228010 - Sequence 209034 from Patent EP1572962.
JD535616 - Sequence 516640 from Patent EP1572962.
JD081171 - Sequence 62195 from Patent EP1572962.
JD551751 - Sequence 532775 from Patent EP1572962.
JD536877 - Sequence 517901 from Patent EP1572962.
JD410758 - Sequence 391782 from Patent EP1572962.
JD503568 - Sequence 484592 from Patent EP1572962.
JD355831 - Sequence 336855 from Patent EP1572962.
JD038856 - Sequence 19880 from Patent EP1572962.
JD560339 - Sequence 541363 from Patent EP1572962.
JD232824 - Sequence 213848 from Patent EP1572962.
JD494907 - Sequence 475931 from Patent EP1572962.
JD039613 - Sequence 20637 from Patent EP1572962.
JD251861 - Sequence 232885 from Patent EP1572962.
JD257966 - Sequence 238990 from Patent EP1572962.
JD342564 - Sequence 323588 from Patent EP1572962.
JD240893 - Sequence 221917 from Patent EP1572962.
JD151987 - Sequence 133011 from Patent EP1572962.
JD348657 - Sequence 329681 from Patent EP1572962.
JD288591 - Sequence 269615 from Patent EP1572962.
JD043916 - Sequence 24940 from Patent EP1572962.
JD206099 - Sequence 187123 from Patent EP1572962.
JD195921 - Sequence 176945 from Patent EP1572962.
JD040742 - Sequence 21766 from Patent EP1572962.
JD134373 - Sequence 115397 from Patent EP1572962.
JD170710 - Sequence 151734 from Patent EP1572962.
JD410028 - Sequence 391052 from Patent EP1572962.
JD143836 - Sequence 124860 from Patent EP1572962.
JD475866 - Sequence 456890 from Patent EP1572962.
JD510118 - Sequence 491142 from Patent EP1572962.
JD220761 - Sequence 201785 from Patent EP1572962.
JD160670 - Sequence 141694 from Patent EP1572962.
JD310836 - Sequence 291860 from Patent EP1572962.
JD060537 - Sequence 41561 from Patent EP1572962.
JD539219 - Sequence 520243 from Patent EP1572962.
JD560233 - Sequence 541257 from Patent EP1572962.
JD117902 - Sequence 98926 from Patent EP1572962.
JD102489 - Sequence 83513 from Patent EP1572962.
JD441561 - Sequence 422585 from Patent EP1572962.
JD254381 - Sequence 235405 from Patent EP1572962.
JD479288 - Sequence 460312 from Patent EP1572962.
JD363025 - Sequence 344049 from Patent EP1572962.
DQ600196 - Homo sapiens piRNA piR-38262, complete sequence.
JD326400 - Sequence 307424 from Patent EP1572962.
JD466509 - Sequence 447533 from Patent EP1572962.
JD276603 - Sequence 257627 from Patent EP1572962.
JD562236 - Sequence 543260 from Patent EP1572962.
JD500949 - Sequence 481973 from Patent EP1572962.
JD539089 - Sequence 520113 from Patent EP1572962.
JD307599 - Sequence 288623 from Patent EP1572962.
JD097118 - Sequence 78142 from Patent EP1572962.
JD097327 - Sequence 78351 from Patent EP1572962.
JD039541 - Sequence 20565 from Patent EP1572962.
JD349610 - Sequence 330634 from Patent EP1572962.
JD050620 - Sequence 31644 from Patent EP1572962.
JD304330 - Sequence 285354 from Patent EP1572962.
JD544973 - Sequence 525997 from Patent EP1572962.
AF401211 - Homo sapiens BCL2 protein mRNA, partial cds.
M13995 - Human B-cell leukemia/lymphoma 2 (bcl-2) proto-oncogene mRNA encoding bcl-2-beta protein, complete cds.
FW409934 - NUCLEIC ACID COMPOUNDS FOR INHIBITING BCL2 GENE EXPRESSION AND USES THEREOF.
JD290397 - Sequence 271421 from Patent EP1572962.
HW917784 - JP 2015062388-A/9: Method for detecting G-quadruplex of nucleic acid strand.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04210 - Apoptosis
hsa04510 - Focal adhesion
hsa04722 - Neurotrophin signaling pathway
hsa05014 - Amyotrophic lateral sclerosis (ALS)
hsa05200 - Pathways in cancer
hsa05210 - Colorectal cancer
hsa05215 - Prostate cancer
hsa05222 - Small cell lung cancer

BioCarta from NCI Cancer Genome Anatomy Project
h_ceramidePathway - Ceramide Signaling Pathway
h_il7Pathway - IL-7 Signal Transduction
h_deathPathway - Induction of apoptosis through DR3 and DR4/5 Death Receptors
h_melanocytepathway - Melanocyte Development and Pigmentation Pathway
h_chemicalPathway - Apoptotic Signaling in Response to DNA Damage
h_il2rbPathway - IL-2 Receptor Beta Chain in T cell Activation
h_keratinocytePathway - Keratinocyte Differentiation
h_telPathway - Telomeres, Telomerase, Cellular Aging, and Immortality
h_mitochondriaPathway - Role of Mitochondria in Apoptotic Signaling
h_prionPathway - Prion Pathway
h_badPathway - Regulation of BAD phosphorylation
h_p53Pathway - p53 Signaling Pathway
h_hsp27Pathway - Stress Induction of HSP Regulation
h_HivnefPathway - HIV-I Nef: negative effector of Fas and TNF

Reactome (by CSHL, EBI, and GO)

Protein P10415 (Reactome details) participates in the following event(s):

R-HSA-114352 Sequestration of tBID by BCL-2
R-HSA-508163 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2
R-HSA-139897 BAD displaces tBID from BCL-2 sequestration
R-HSA-879201 Bcl-2 and Bcl-XL bind NLRP1
R-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-111447 Activation of BAD and translocation to mitochondria
R-HSA-844455 The NLRP1 inflammasome
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-109606 Intrinsic Pathway for Apoptosis
R-HSA-8939211 ESR-mediated signaling
R-HSA-114452 Activation of BH3-only proteins
R-HSA-622312 Inflammasomes
R-HSA-449147 Signaling by Interleukins
R-HSA-109581 Apoptosis
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-5357801 Programmed Cell Death
R-HSA-162582 Signal Transduction
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: BCL2_HUMAN, NM_000633, P10415, P10416, Q13842, Q16197, uc002liu.1, uc002liu.2
UCSC ID: uc002liu.2
RefSeq Accession: NM_000633
Protein: P10415 (aka BCL2_HUMAN)
CCDS: CCDS11981.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.