Human Gene AGTR2 (ENST00000371906.5) from GENCODE V41
Description: Homo sapiens angiotensin II receptor type 2 (AGTR2), transcript variant 1, mRNA. (from RefSeq NM_000686) RefSeq Summary (NM_000686): The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus and in neonates, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2 infection results in down-regulation of angiotensin converting enzyme-2 (ACE2) receptors, the effects of which, triggers serious inflammatory lesions in the tissues involved, primarily in the lungs. The inflammatory reaction appears to be mediated by angiotensin II derivatives, including the angiotensin AT2 receptor which has been found to be upregulated in bronchoalveolar lavage samples from Coronavirus disease 2019 (COVID19) patients. [provided by RefSeq, Jul 2020]. Gencode Transcript: ENST00000371906.5 Gencode Gene: ENSG00000180772.8 Transcript (Including UTRs) Position: hg38 chrX:116,170,744-116,174,974 Size: 4,231 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chrX:116,172,281-116,173,372 Size: 1,092 Coding Exon Count: 1
ID:AGTR2_HUMAN DESCRIPTION: RecName: Full=Type-2 angiotensin II receptor; AltName: Full=Angiotensin II type-2 receptor; Short=AT2; FUNCTION: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. SUBUNIT: Interacts with MTUS1. INTERACTION: P35625:TIMP3; NbExp=7; IntAct=EBI-1748067, EBI-1748085; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine. DISEASE: Defects in AGTR2 are the cause of mental retardation X- linked type 88 (MRX88) [MIM:300852]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/AGTR2";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P50052
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF211444 - JP 2014500723-A/18947: Polycomb-Associated Non-Coding RNAs. MA447021 - JP 2018138019-A/18947: Polycomb-Associated Non-Coding RNAs. AK313927 - Homo sapiens cDNA, FLJ94566, Homo sapiens angiotensin II receptor, type 2 (AGTR2), mRNA. X87723 - H.sapiens mRNA for angiotensin ii type receptor, mRNA, 5' untranslated region. LF214067 - JP 2014500723-A/21570: Polycomb-Associated Non-Coding RNAs. MA449644 - JP 2018138019-A/21570: Polycomb-Associated Non-Coding RNAs. U16957 - Human angiotensin II type 2 receptor mRNA, complete cds. BC095504 - Homo sapiens angiotensin II receptor, type 2, mRNA (cDNA clone MGC:111714 IMAGE:6971944), complete cds. LF379648 - JP 2014500723-A/187151: Polycomb-Associated Non-Coding RNAs. MA615225 - JP 2018138019-A/187151: Polycomb-Associated Non-Coding RNAs. AB463410 - Synthetic construct DNA, clone: pF1KB7158, Homo sapiens AGTR2 gene for angiotensin II receptor, type 2, without stop codon, in Flexi system. CR541969 - Homo sapiens full open reading frame cDNA clone RZPDo834H1034D for gene AGTR2, angiotensin II receptor, type 2; complete cds, without stopcodon. LF379649 - JP 2014500723-A/187152: Polycomb-Associated Non-Coding RNAs. MA615226 - JP 2018138019-A/187152: Polycomb-Associated Non-Coding RNAs. LF379650 - JP 2014500723-A/187153: Polycomb-Associated Non-Coding RNAs. MA615227 - JP 2018138019-A/187153: Polycomb-Associated Non-Coding RNAs. LF379651 - JP 2014500723-A/187154: Polycomb-Associated Non-Coding RNAs. MA615228 - JP 2018138019-A/187154: Polycomb-Associated Non-Coding RNAs. LF379652 - JP 2014500723-A/187155: Polycomb-Associated Non-Coding RNAs. MA615229 - JP 2018138019-A/187155: Polycomb-Associated Non-Coding RNAs. LF379653 - JP 2014500723-A/187156: Polycomb-Associated Non-Coding RNAs. MA615230 - JP 2018138019-A/187156: Polycomb-Associated Non-Coding RNAs. JD493463 - Sequence 474487 from Patent EP1572962. LF379654 - JP 2014500723-A/187157: Polycomb-Associated Non-Coding RNAs. MA615231 - JP 2018138019-A/187157: Polycomb-Associated Non-Coding RNAs. LF379655 - JP 2014500723-A/187158: Polycomb-Associated Non-Coding RNAs. MA615232 - JP 2018138019-A/187158: Polycomb-Associated Non-Coding RNAs. JD084689 - Sequence 65713 from Patent EP1572962. JD063596 - Sequence 44620 from Patent EP1572962. JD350397 - Sequence 331421 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04080 - Neuroactive ligand-receptor interaction hsa04614 - Renin-angiotensin system
BioCarta from NCI Cancer Genome Anatomy Project h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway h_cardiacegfPathway - Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy h_ace2Pathway - Angiotensin-converting enzyme 2 regulates heart function