Human Gene AVPR1B (ENST00000367126.5)
  Description: Homo sapiens arginine vasopressin receptor 1B (AVPR1B), mRNA. (from RefSeq NM_000707)
RefSeq Summary (NM_000707): The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Gencode Transcript: ENST00000367126.5
Gencode Gene: ENSG00000198049.7
Transcript (Including UTRs)
   Position: hg38 chr1:206,106,936-206,117,388 Size: 10,453 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr1:206,110,189-206,116,890 Size: 6,702 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:206,106,936-206,117,388)mRNA (may differ from genome)Protein (424 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: V1BR_HUMAN
DESCRIPTION: RecName: Full=Vasopressin V1b receptor; Short=V1bR; AltName: Full=AVPR V1b; AltName: Full=AVPR V3; AltName: Full=Antidiuretic hormone receptor 1b; AltName: Full=Vasopressin V3 receptor;
FUNCTION: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/avpr1b/";

-  MalaCards Disease Associations
  MalaCards Gene Search: AVPR1B
Diseases sorted by gene-association score: acth-independent macronodular adrenal hyperplasia (8), asperger syndrome (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C456029 1-(5-chloro-1-((2,4-dimethoxyphenyl)sulfonyl)-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • D000081 Acetamides
  • D000535 Aluminum
  • D000643 Ammonium Chloride
  • D004026 Dieldrin
  • D004051 Diethylhexyl Phthalate
  • D019833 Genistein
  • D007657 Ketone Bodies
  • D008731 Methoxychlor
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.10 RPKM in Pituitary
Total median expression: 5.25 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -113.60498-0.228 Picture PostScript Text
3' UTR -1137.103253-0.350 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR001817 - Vasoprsn_rcpt
IPR000628 - Vprs_rcpt_V1B

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on P47901
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0005000 vasopressin receptor activity
GO:0005080 protein kinase C binding
GO:0042277 peptide binding

Biological Process:
GO:0001992 regulation of systemic arterial blood pressure by vasopressin
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0032870 cellular response to hormone stimulus
GO:0045907 positive regulation of vasoconstriction
GO:1901652 response to peptide

Cellular Component:
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  L37112 - Homo sapiens vasopressin V3 receptor mRNA, complete cds.
JD265420 - Sequence 246444 from Patent EP1572962.
JD258046 - Sequence 239070 from Patent EP1572962.
JD358235 - Sequence 339259 from Patent EP1572962.
D31833 - Homo sapiens mRNA for vasopressin V1b receptor, complete cds.
JD369415 - Sequence 350439 from Patent EP1572962.
JD146542 - Sequence 127566 from Patent EP1572962.
JD338747 - Sequence 319771 from Patent EP1572962.
JD205964 - Sequence 186988 from Patent EP1572962.
JD496752 - Sequence 477776 from Patent EP1572962.
JD190973 - Sequence 171997 from Patent EP1572962.
JD270723 - Sequence 251747 from Patent EP1572962.
AF030512 - Homo sapiens small cell vasopressin subtype 1b receptor mRNA, complete cds.
AF101726 - Homo sapiens vasopressin receptor subtype 1b mRNA, complete cds.
EU432111 - Homo sapiens arginine vasopressin receptor 1b (AVPR1B) mRNA, complete cds.
BC157126 - Synthetic construct Homo sapiens clone IMAGE:100063517, MGC:190790 arginine vasopressin receptor 1B (AVPR1B) mRNA, encodes complete protein.
BC156078 - Synthetic construct Homo sapiens clone IMAGE:100062345, MGC:190473 arginine vasopressin receptor 1B (AVPR1B) mRNA, encodes complete protein.
AB528977 - Synthetic construct DNA, clone: pF1KE0738, Homo sapiens AVPR1B gene for arginine vasopressin receptor 1B, without stop codon, in Flexi system.
JD447781 - Sequence 428805 from Patent EP1572962.
JD167064 - Sequence 148088 from Patent EP1572962.
JD201102 - Sequence 182126 from Patent EP1572962.
JD358305 - Sequence 339329 from Patent EP1572962.
JD559888 - Sequence 540912 from Patent EP1572962.
JD419050 - Sequence 400074 from Patent EP1572962.
JD521525 - Sequence 502549 from Patent EP1572962.
JD384945 - Sequence 365969 from Patent EP1572962.
JD439669 - Sequence 420693 from Patent EP1572962.
JD086885 - Sequence 67909 from Patent EP1572962.
JD377129 - Sequence 358153 from Patent EP1572962.
JD262794 - Sequence 243818 from Patent EP1572962.
JD253062 - Sequence 234086 from Patent EP1572962.
JD415826 - Sequence 396850 from Patent EP1572962.
JD225182 - Sequence 206206 from Patent EP1572962.
JD446177 - Sequence 427201 from Patent EP1572962.
JD092637 - Sequence 73661 from Patent EP1572962.
JD520470 - Sequence 501494 from Patent EP1572962.
JD077004 - Sequence 58028 from Patent EP1572962.
JD218696 - Sequence 199720 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04020 - Calcium signaling pathway
hsa04080 - Neuroactive ligand-receptor interaction
hsa04270 - Vascular smooth muscle contraction

Reactome (by CSHL, EBI, and GO)

Protein P47901 (Reactome details) participates in the following event(s):

R-HSA-388468 AVP(20-28) binds AVPR1A,B
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-388479 Vasopressin-like receptors
R-HSA-5619099 Defective AVP causes neurohypophyseal diabetes insipidus (NDI)
R-HSA-416476 G alpha (q) signalling events
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-5619102 SLC transporter disorders
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-5619115 Disorders of transmembrane transporters
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-1643685 Disease
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: AVPR3, B0M0J6, ENST00000367126.1, ENST00000367126.2, ENST00000367126.3, ENST00000367126.4, NM_000707, P47901, Q5TZ00, uc001hds.1, uc001hds.2, uc001hds.3, uc001hds.4, V1BR_HUMAN, VPR3
UCSC ID: ENST00000367126.5
RefSeq Accession: NM_000707
Protein: P47901 (aka V1BR_HUMAN)
CCDS: CCDS73015.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.