Human Gene AVPR1B (ENST00000367126.5) from GENCODE V39
Description: Homo sapiens arginine vasopressin receptor 1B (AVPR1B), mRNA. (from RefSeq NM_000707) RefSeq Summary (NM_000707): The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000367126.5 Gencode Gene: ENSG00000198049.7 Transcript (Including UTRs) Position: hg38 chr1:206,106,936-206,117,388 Size: 10,453 Total Exon Count: 2 Strand: - Coding Region Position: hg38 chr1:206,110,189-206,116,890 Size: 6,702 Coding Exon Count: 2
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P47901
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004871 signal transducer activity GO:0004930 G-protein coupled receptor activity GO:0005000 vasopressin receptor activity GO:0005080 protein kinase C binding GO:0042277 peptide binding
Biological Process: GO:0001992 regulation of systemic arterial blood pressure by vasopressin GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007202 activation of phospholipase C activity GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0032870 cellular response to hormone stimulus GO:0045907 positive regulation of vasoconstriction GO:1901652 response to peptide
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