Description: Homo sapiens monoamine oxidase B (MAOB), mRNA. (from RefSeq NM_000898) RefSeq Summary (NM_000898): The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000378069.5 Gencode Gene: ENSG00000069535.14 Transcript (Including UTRs) Position: hg38 chrX:43,766,610-43,882,450 Size: 115,841 Total Exon Count: 15 Strand: - Coding Region Position: hg38 chrX:43,767,466-43,882,299 Size: 114,834 Coding Exon Count: 15
ID:AOFB_HUMAN DESCRIPTION: RecName: Full=Amine oxidase [flavin-containing] B; EC=220.127.116.11; AltName: Full=Monoamine oxidase type B; Short=MAO-B; FUNCTION: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. CATALYTIC ACTIVITY: RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2). COFACTOR: FAD. SUBUNIT: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity). SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. MASS SPECTROMETRY: Mass=59474; Mass_error=14.0; Method=Electrospray; Range=2-520; Source=PubMed:11049757; SIMILARITY: Belongs to the flavin monoamine oxidase family. WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=MAOB"; WEB RESOURCE: Name=Wikipedia; Note=Monoamine oxidase entry; URL="http://en.wikipedia.org/wiki/Monoamine_oxidase";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P27338
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.