Human Gene OXT (ENST00000217386.2) from GENCODE V39
Description: Homo sapiens oxytocin/neurophysin I prepropeptide (OXT), mRNA. (from RefSeq NM_000915) RefSeq Summary (NM_000915): This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013]. Gencode Transcript: ENST00000217386.2 Gencode Gene: ENSG00000101405.3 Transcript (Including UTRs) Position: hg38 chr20:3,071,620-3,072,517 Size: 898 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr20:3,071,656-3,072,418 Size: 763 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
