Human Gene PTGS2 (ENST00000367468.10) Description and Page Index
  Description: Homo sapiens prostaglandin-endoperoxide synthase 2 (PTGS2), mRNA. (from RefSeq NM_000963)
RefSeq Summary (NM_000963): Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013734.1, SRR1660807.206449.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367468.10/ ENSP00000356438.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000367468.10
Gencode Gene: ENSG00000073756.12
Transcript (Including UTRs)
   Position: hg38 chr1:186,671,791-186,680,423 Size: 8,633 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg38 chr1:186,674,353-186,680,290 Size: 5,938 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:186,671,791-186,680,423)mRNA (may differ from genome)Protein (604 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: PGH2_HUMAN
DESCRIPTION: RecName: Full=Prostaglandin G/H synthase 2; EC=1.14.99.1; AltName: Full=Cyclooxygenase-2; Short=COX-2; AltName: Full=PHS II; AltName: Full=Prostaglandin H2 synthase 2; Short=PGH synthase 2; Short=PGHS-2; AltName: Full=Prostaglandin-endoperoxide synthase 2; Flags: Precursor;
FUNCTION: Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.
CATALYTIC ACTIVITY: Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.
COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group per subunit (By similarity).
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=16.2 uM for arachidonate (in absence of sodium nitroprusside NO donor); KM=17.0 uM for arachidonate (in presence of sodium nitroprusside NO donor); Vmax=81.3 nmol/min/mg enzyme (in absence of sodium nitroprusside NO donor); Vmax=132 nmol/min/mg enzyme (in absence of sodium nitroprusside NO donor);
PATHWAY: Lipid metabolism; prostaglandin biosynthesis.
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
INDUCTION: By cytokines and mitogens.
PTM: S-nitrosylation by NOS2 (iNOS) activates enzme activity. S- nitrosylation may take place on different Cys residues in addition to Cys-561.
MISCELLANEOUS: This enzyme acts both as a dioxygenase and as a peroxidase.
MISCELLANEOUS: This enzyme is the target of nonsteroidal anti- inflammatory drugs such as aspirin.
SIMILARITY: Belongs to the prostaglandin G/H synthase family.
SIMILARITY: Contains 1 EGF-like domain.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PTGS2ID509ch1q31.html";
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ptgs2/";
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/ptgs2/";

-  MalaCards Disease Associations
  MalaCards Gene Search: PTGS2
Diseases sorted by gene-association score: colorectal adenoma (25), peptic ulcer disease (22), bursitis (21), gastric ulcer (20), stomach disease (18), familial adenomatous polyposis (18), uterine carcinosarcoma (16), gastric adenocarcinoma (15), gallbladder papillary carcinoma (15), colorectal cancer (14), protoplasmic astrocytoma (13), gastritis (13), lung cancer (13), chronic pain (13), rheumatic disease (13), colon adenocarcinoma (12), squamous cell carcinoma (12), intestinal benign neoplasm (12), barrett's adenocarcinoma (12), actinic keratosis (11), headache (11), h. pylori infection (11), hemophilic arthropathy (10), hereditary mixed polyposis syndrome (10), oral submucous fibrosis (10), inflamed seborrheic keratosis (10), adenocarcinoma (10), barrett esophagus/esophageal adenocarcinoma (10), gastrointestinal system benign neoplasm (9), bile duct carcinoma (9), osteoarthritis (9), urinary tract obstruction (9), dyspepsia (9), active peptic ulcer disease (9), transitional cell carcinoma (9), urticaria (9), angioedema (9), acute generalized exanthematous pustulosis (8), photoallergic dermatitis (8), leukorrhea (8), ureteral obstruction (8), esophagus adenocarcinoma (8), osteoarthritis-5 (8), esophagitis (7), stomach cancer (7), spondylolisthesis (7), gallbladder cancer (7), cholangiocarcinoma, susceptibility to (7), hereditary mixed polyposis syndrome 1 (7), arthritis (7), ovarian serous carcinoma (7), keratocystic odontogenic tumor (7), cervical adenocarcinoma (7), bowenoid papulosis (7), antenatal bartter syndrome (7), ovarian epithelial cancer (7), acute endometritis (7), hepatocellular carcinoma (6), ductal carcinoma in situ (6), bile reflux (6), clopidogrel resistance (6), oral cancer (6), morphine dependence (6), gastroesophageal reflux (6), cystitis (6), pharyngitis (6), bartter syndrome, type 2 (6), autoinflammation, lipodystrophy, and dermatosis syndrome (6), fanconi-like syndrome (6), adenomyosis (5), parkinson disease susceptibility (5), patent ductus arteriosus (5), alveolar periostitis (5), balanitis xerotica obliterans (5), skin melanoma (5), chronic cystitis (5), hydrops, lactic acidosis, and sideroblastic anemia (5), pyosalpinx (5), peptic ulcer perforation (5), functional gastric disease (5), cervical adenosquamous carcinoma (4), adenoma (4), esophageal disease (4), endometriosis (4), shoulder impingement syndrome (4), bladder squamous cell carcinoma (4), esophageal cancer (4), colonic benign neoplasm (3), oral squamous cell carcinoma (3), urinary bladder cancer (3), rheumatoid arthritis (3), colorectal adenocarcinoma (3), myocardial infarction (3), pancreatic cancer (3), prostate cancer (2), breast cancer (2), squamous cell carcinoma, head and neck (2), lung cancer susceptibility 3 (2), gastrointestinal system cancer (2), bone inflammation disease (2), bladder cancer, somatic (2), adamantinoma of long bones (1), gastric cancer, somatic (1), ovarian cancer, somatic (1), gastrointestinal system disease (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.01 RPKM in Lung
Total median expression: 73.97 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -33.50133-0.252 Picture PostScript Text
3' UTR -560.902562-0.219 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000742 - EG-like_dom
IPR010255 - Haem_peroxidase
IPR002007 - Haem_peroxidase_animal
IPR019791 - Haem_peroxidase_animal_subgr

Pfam Domains:
PF03098 - Animal haem peroxidase

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1V0X
- Model


ModBase Predicted Comparative 3D Structure on P35354
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004601 peroxidase activity
GO:0004666 prostaglandin-endoperoxide synthase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0050473 arachidonate 15-lipoxygenase activity
GO:0051213 dioxygenase activity

Biological Process:
GO:0001516 prostaglandin biosynthetic process
GO:0001525 angiogenesis
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006693 prostaglandin metabolic process
GO:0006954 inflammatory response
GO:0006979 response to oxidative stress
GO:0007566 embryo implantation
GO:0007568 aging
GO:0007612 learning
GO:0007613 memory
GO:0008217 regulation of blood pressure
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009314 response to radiation
GO:0009750 response to fructose
GO:0010033 response to organic substance
GO:0010042 response to manganese ion
GO:0010226 response to lithium ion
GO:0010243 response to organonitrogen compound
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010942 positive regulation of cell death
GO:0014070 response to organic cyclic compound
GO:0019221 cytokine-mediated signaling pathway
GO:0019233 sensory perception of pain
GO:0019371 cyclooxygenase pathway
GO:0019372 lipoxygenase pathway
GO:0030282 bone mineralization
GO:0030728 ovulation
GO:0031394 positive regulation of prostaglandin biosynthetic process
GO:0031622 positive regulation of fever generation
GO:0031915 positive regulation of synaptic plasticity
GO:0032227 negative regulation of synaptic transmission, dopaminergic
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033280 response to vitamin D
GO:0034097 response to cytokine
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway
GO:0034605 cellular response to heat
GO:0034612 response to tumor necrosis factor
GO:0034644 cellular response to UV
GO:0035633 maintenance of permeability of blood-brain barrier
GO:0042127 regulation of cell proliferation
GO:0042307 positive regulation of protein import into nucleus
GO:0042493 response to drug
GO:0042633 hair cycle
GO:0042759 long-chain fatty acid biosynthetic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045786 negative regulation of cell cycle
GO:0045907 positive regulation of vasoconstriction
GO:0045986 negative regulation of smooth muscle contraction
GO:0045987 positive regulation of smooth muscle contraction
GO:0046697 decidualization
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050727 regulation of inflammatory response
GO:0050873 brown fat cell differentiation
GO:0051384 response to glucocorticoid
GO:0051926 negative regulation of calcium ion transport
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0055114 oxidation-reduction process
GO:0070542 response to fatty acid
GO:0071260 cellular response to mechanical stimulus
GO:0071284 cellular response to lead ion
GO:0071318 cellular response to ATP
GO:0071456 cellular response to hypoxia
GO:0071471 cellular response to non-ionic osmotic stress
GO:0071498 cellular response to fluid shear stress
GO:0071636 positive regulation of transforming growth factor beta production
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090271 positive regulation of fibroblast growth factor production
GO:0090336 positive regulation of brown fat cell differentiation
GO:0090362 positive regulation of platelet-derived growth factor production
GO:0098869 cellular oxidant detoxification
GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
GO:1990776 response to angiotensin

Cellular Component:
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005901 caveola
GO:0016020 membrane
GO:0031090 organelle membrane
GO:0032991 macromolecular complex
GO:0043005 neuron projection
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  LF205384 - JP 2014500723-A/12887: Polycomb-Associated Non-Coding RNAs.
MA440961 - JP 2018138019-A/12887: Polycomb-Associated Non-Coding RNAs.
LP895764 - Sequence 628 from Patent EP3253886.
LQ882880 - Sequence 29 from Patent WO2018160841.
MS997858 - Sequence 13 from Patent EP3159403.
FW340033 - Screening.
JD232281 - Sequence 213305 from Patent EP1572962.
LF319882 - JP 2014500723-A/127385: Polycomb-Associated Non-Coding RNAs.
MA555459 - JP 2018138019-A/127385: Polycomb-Associated Non-Coding RNAs.
LF213698 - JP 2014500723-A/21201: Polycomb-Associated Non-Coding RNAs.
MA449275 - JP 2018138019-A/21201: Polycomb-Associated Non-Coding RNAs.
JD563985 - Sequence 545009 from Patent EP1572962.
JD228320 - Sequence 209344 from Patent EP1572962.
LF319881 - JP 2014500723-A/127384: Polycomb-Associated Non-Coding RNAs.
MA555458 - JP 2018138019-A/127384: Polycomb-Associated Non-Coding RNAs.
LF319880 - JP 2014500723-A/127383: Polycomb-Associated Non-Coding RNAs.
MA555457 - JP 2018138019-A/127383: Polycomb-Associated Non-Coding RNAs.
LF319879 - JP 2014500723-A/127382: Polycomb-Associated Non-Coding RNAs.
MA555456 - JP 2018138019-A/127382: Polycomb-Associated Non-Coding RNAs.
LF319878 - JP 2014500723-A/127381: Polycomb-Associated Non-Coding RNAs.
MA555455 - JP 2018138019-A/127381: Polycomb-Associated Non-Coding RNAs.
JD341535 - Sequence 322559 from Patent EP1572962.
JD337369 - Sequence 318393 from Patent EP1572962.
JD309613 - Sequence 290637 from Patent EP1572962.
JD299310 - Sequence 280334 from Patent EP1572962.
L15326 - Human endoperoxide synthase type II mRNA, complete cds.
AY151286 - Homo sapiens cyclooxygenase 2b mRNA, complete cds; alternatively spliced.
M90100 - Homo sapiens cyclooxygenase-2 (Cox-2) mRNA, complete cds.
BC013734 - Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase), mRNA (cDNA clone MGC:9576 IMAGE:3880850), complete cds.
JD514507 - Sequence 495531 from Patent EP1572962.
JD362897 - Sequence 343921 from Patent EP1572962.
JD298371 - Sequence 279395 from Patent EP1572962.
JD359539 - Sequence 340563 from Patent EP1572962.
JD229886 - Sequence 210910 from Patent EP1572962.
LF319877 - JP 2014500723-A/127380: Polycomb-Associated Non-Coding RNAs.
MA555454 - JP 2018138019-A/127380: Polycomb-Associated Non-Coding RNAs.
JD088441 - Sequence 69465 from Patent EP1572962.
JD299627 - Sequence 280651 from Patent EP1572962.
JD042287 - Sequence 23311 from Patent EP1572962.
LF319876 - JP 2014500723-A/127379: Polycomb-Associated Non-Coding RNAs.
MA555453 - JP 2018138019-A/127379: Polycomb-Associated Non-Coding RNAs.
JD302949 - Sequence 283973 from Patent EP1572962.
JD058748 - Sequence 39772 from Patent EP1572962.
LF319875 - JP 2014500723-A/127378: Polycomb-Associated Non-Coding RNAs.
MA555452 - JP 2018138019-A/127378: Polycomb-Associated Non-Coding RNAs.
JD565899 - Sequence 546923 from Patent EP1572962.
JD046199 - Sequence 27223 from Patent EP1572962.
LF319874 - JP 2014500723-A/127377: Polycomb-Associated Non-Coding RNAs.
MA555451 - JP 2018138019-A/127377: Polycomb-Associated Non-Coding RNAs.
JD501520 - Sequence 482544 from Patent EP1572962.
AK292167 - Homo sapiens cDNA FLJ75306 complete cds, highly similar to Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase), mRNA.
AJ634912 - Homo sapiens mRNA for putative cyclooxygenase-2 (COX-2 gene), splice variant COX-2a.
AY462100 - Homo sapiens cyclooxygenase 2 (COX2) mRNA, complete cds.
EU176282 - Synthetic construct Homo sapiens clone IMAGE:100006390; FLH177295.01X; RZPDo839G12250D prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (PTGS2) gene, encodes complete protein.
KJ891942 - Synthetic construct Homo sapiens clone ccsbBroadEn_01336 PTGS2 gene, encodes complete protein.
KR709390 - Synthetic construct Homo sapiens clone CCSBHm_00001791 PTGS2 (PTGS2) mRNA, encodes complete protein.
EU176597 - Synthetic construct Homo sapiens clone IMAGE:100011402; FLH177291.01L; RZPDo839G03254D prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (PTGS2) gene, encodes complete protein.
AB385033 - Synthetic construct DNA, clone: pF1KB5091, Homo sapiens PTGS2 gene for prostaglandin G/H synthase 2 precursor, complete cds, without stop codon, in Flexi system.
LF319873 - JP 2014500723-A/127376: Polycomb-Associated Non-Coding RNAs.
MA555450 - JP 2018138019-A/127376: Polycomb-Associated Non-Coding RNAs.
LF319872 - JP 2014500723-A/127375: Polycomb-Associated Non-Coding RNAs.
MA555449 - JP 2018138019-A/127375: Polycomb-Associated Non-Coding RNAs.
LF319871 - JP 2014500723-A/127374: Polycomb-Associated Non-Coding RNAs.
MA555448 - JP 2018138019-A/127374: Polycomb-Associated Non-Coding RNAs.
LF319870 - JP 2014500723-A/127373: Polycomb-Associated Non-Coding RNAs.
MA555447 - JP 2018138019-A/127373: Polycomb-Associated Non-Coding RNAs.
LF319869 - JP 2014500723-A/127372: Polycomb-Associated Non-Coding RNAs.
MA555446 - JP 2018138019-A/127372: Polycomb-Associated Non-Coding RNAs.
CU680666 - Synthetic construct Homo sapiens gateway clone IMAGE:100019929 5' read PTGS2 mRNA.
LF319868 - JP 2014500723-A/127371: Polycomb-Associated Non-Coding RNAs.
MA555445 - JP 2018138019-A/127371: Polycomb-Associated Non-Coding RNAs.
LF206652 - JP 2014500723-A/14155: Polycomb-Associated Non-Coding RNAs.
MA442229 - JP 2018138019-A/14155: Polycomb-Associated Non-Coding RNAs.
LF356929 - JP 2014500723-A/164432: Polycomb-Associated Non-Coding RNAs.
MA592506 - JP 2018138019-A/164432: Polycomb-Associated Non-Coding RNAs.
LF319867 - JP 2014500723-A/127370: Polycomb-Associated Non-Coding RNAs.
MA555444 - JP 2018138019-A/127370: Polycomb-Associated Non-Coding RNAs.
LF211762 - JP 2014500723-A/19265: Polycomb-Associated Non-Coding RNAs.
MA447339 - JP 2018138019-A/19265: Polycomb-Associated Non-Coding RNAs.
LF319866 - JP 2014500723-A/127369: Polycomb-Associated Non-Coding RNAs.
MA555443 - JP 2018138019-A/127369: Polycomb-Associated Non-Coding RNAs.
HM473188 - Homo sapiens prostaglandin-endoperoxidase synthase 2 (PTGS2) mRNA, partial cds.
JD054658 - Sequence 35682 from Patent EP1572962.
JD114995 - Sequence 96019 from Patent EP1572962.
JD205443 - Sequence 186467 from Patent EP1572962.
JD083846 - Sequence 64870 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00590 - Arachidonic acid metabolism
hsa04370 - VEGF signaling pathway
hsa05140 - Leishmaniasis
hsa05200 - Pathways in cancer
hsa05222 - Small cell lung cancer

BioCyc Knowledge Library
PWY66-374 - C20 prostanoid biosynthesis
PWY66-393 - aspirin-triggered lipoxin biosynthesis
PWY66-394 - aspirin triggered resolvin E biosynthesis
PWY66-395 - aspirin triggered resolvin D biosynthesis

BioCarta from NCI Cancer Genome Anatomy Project
h_AcetaminophenPathway - Mechanism of Acetaminophen Activity and Toxicity
h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)
h_eicosanoidPathway - Eicosanoid Metabolism

Reactome (by CSHL, EBI, and GO)

Protein P35354 (Reactome details) participates in the following event(s):

R-HSA-2309779 PTGS2 dimer binds celecoxib
R-HSA-2314686 Aspirin acetylates PTGS2
R-HSA-2309787 Arachidonic acid is oxidised to PGG2 by PTGS2
R-HSA-2309773 PGG2 is reduced to PGH2 by PTGS2
R-HSA-9026408 PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3
R-HSA-9027532 PTGS2 dimer oxidises DHA to 13-HDHA
R-HSA-9028255 PTGS2 dimer oxidises EPA to PGH3
R-HSA-2161951 Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2
R-HSA-9020261 Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA
R-HSA-9027607 Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3
R-HSA-9027627 Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages)
R-HSA-9018880 Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-HSA-449147 Signaling by Interleukins
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-197264 Nicotinamide salvaging
R-HSA-9025094 Biosynthesis of DPAn-3 SPMs
R-HSA-9027604 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
R-HSA-2142770 Synthesis of 15-eicosatetraenoic acid derivatives
R-HSA-9018677 Biosynthesis of DHA-derived SPMs
R-HSA-9018679 Biosynthesis of EPA-derived SPMs
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-8978868 Fatty acid metabolism
R-HSA-196807 Nicotinate metabolism
R-HSA-9018683 Biosynthesis of DPA-derived SPMs
R-HSA-9018678 Biosynthesis of specialized proresolving mediators (SPMs)
R-HSA-168256 Immune System
R-HSA-556833 Metabolism of lipids
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
R-HSA-1430728 Metabolism
R-HSA-196854 Metabolism of vitamins and cofactors

-  Other Names for This Gene
  Alternate Gene Symbols: A8K802, COX2, NM_000963, P35354, PGH2_HUMAN, Q16876, uc001gsb.1, uc001gsb.2, uc001gsb.3, uc001gsb.4, uc001gsb.5
UCSC ID: uc001gsb.5
RefSeq Accession: NM_000963
Protein: P35354 (aka PGH2_HUMAN)
CCDS: CCDS1371.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.