Human Gene CACNA1I (ENST00000404898.5) from GENCODE V44
Description: Homo sapiens calcium voltage-gated channel subunit alpha1 I (CACNA1I), transcript variant 2, mRNA. (from RefSeq NM_001003406) RefSeq Summary (NM_001003406): This gene encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by this protein is characterized by a slower activation and inactivation compared to other T-type calcium channels. This protein may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]. Gencode Transcript: ENST00000404898.5 Gencode Gene: ENSG00000100346.18 Transcript (Including UTRs) Position: hg38 chr22:39,570,753-39,689,730 Size: 118,978 Total Exon Count: 36 Strand: + Coding Region Position: hg38 chr22:39,570,753-39,686,405 Size: 115,653 Coding Exon Count: 36
ID:CAC1I_HUMAN DESCRIPTION: RecName: Full=Voltage-dependent T-type calcium channel subunit alpha-1I; AltName: Full=Voltage-gated calcium channel subunit alpha Cav3.3; Short=Ca(v)3.3; FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (By similarity). SUBUNIT: Interacts with CATSPER1 and CATSPER2, leading to suppress T-type calcium channel activity. INTERACTION: Q8NEC5:CATSPER1; NbExp=5; IntAct=EBI-1220829, EBI-744545; Q96P56:CATSPER2; NbExp=3; IntAct=EBI-1220829, EBI-2215024; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Brain specific. DOMAIN: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. PTM: In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II (By similarity). SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1I subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P0X4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006816 calcium ion transport GO:0007165 signal transduction GO:0019228 neuronal action potential GO:0030317 flagellated sperm motility GO:0030431 sleep GO:0034765 regulation of ion transmembrane transport GO:0035725 sodium ion transmembrane transport GO:0045956 positive regulation of calcium ion-dependent exocytosis GO:0055085 transmembrane transport GO:0070509 calcium ion import GO:0070588 calcium ion transmembrane transport GO:0086010 membrane depolarization during action potential
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