Human Gene SSTR1 (ENST00000267377.3)
  Description: Homo sapiens somatostatin receptor 1 (SSTR1), mRNA. (from RefSeq NM_001049)
RefSeq Summary (NM_001049): Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012].
Gencode Transcript: ENST00000267377.3
Gencode Gene: ENSG00000139874.6
Transcript (Including UTRs)
   Position: hg38 chr14:38,207,904-38,213,067 Size: 5,164 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr14:38,209,390-38,210,565 Size: 1,176 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:38,207,904-38,213,067)mRNA (may differ from genome)Protein (391 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: SSR1_HUMAN
DESCRIPTION: RecName: Full=Somatostatin receptor type 1; Short=SS-1-R; Short=SS1-R; Short=SS1R; AltName: Full=SRIF-2;
FUNCTION: Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
SUBUNIT: Interacts with SKB1.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  MalaCards Disease Associations
  MalaCards Gene Search: SSTR1
Diseases sorted by gene-association score: acromegaly (4), pituitary adenoma, prolactin-secreting (3), medullary thyroid carcinoma, familial (3), oncogenic osteomalacia (2), small intestine neuroendocrine neoplasm (2), ectopic cushing syndrome (1), serotonin syndrome (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C488795 1,2,3,4,4a,5,10,10a-octahydro-6-methoxy-1-methylbenz(g)quinoline-3-carboxylic acid 4-(4-nitrophenyl)piperazine amide
  • C049325 1,2-dithiol-3-thione
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C530475 7-(7-amino-7-methyl-5-azaspiro(2.4)heptan-5-yl)-6-fluoro-1-(2-fluoro-1-cyclopropyl)-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
  • D000639 Amitriptyline
  • D000643 Ammonium Chloride
  • D001761 Bleomycin
  • D019256 Cadmium Chloride
  • D003042 Cocaine
  • C505440 DX 619
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.65 RPKM in Stomach
Total median expression: 71.26 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -308.90712-0.434 Picture PostScript Text
3' UTR -859.002502-0.343 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR000586 - Somatstn_rcpt
IPR001116 - Somatstn_rcpt_1

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on P30872
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004994 somatostatin receptor activity
GO:0042923 neuropeptide binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007215 glutamate receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007283 spermatogenesis
GO:0008285 negative regulation of cell proliferation
GO:0021549 cerebellum development
GO:0030900 forebrain development
GO:0038170 somatostatin signaling pathway
GO:0042594 response to starvation
GO:0071392 cellular response to estradiol stimulus
GO:1990830 cellular response to leukemia inhibitory factor

Cellular Component:
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043005 neuron projection


-  Descriptions from all associated GenBank mRNAs
  BX248780 - human full-length cDNA 5-PRIME end of clone CS0DK011YG11 of HeLa cells of Homo sapiens (human).
AK290868 - Homo sapiens cDNA FLJ77095 complete cds.
BC035618 - Homo sapiens somatostatin receptor 1, mRNA (cDNA clone MGC:45280 IMAGE:5175220), complete cds.
JD415336 - Sequence 396360 from Patent EP1572962.
JD159475 - Sequence 140499 from Patent EP1572962.
JD125198 - Sequence 106222 from Patent EP1572962.
JD467380 - Sequence 448404 from Patent EP1572962.
JD535741 - Sequence 516765 from Patent EP1572962.
JD445744 - Sequence 426768 from Patent EP1572962.
JD138721 - Sequence 119745 from Patent EP1572962.
KJ892207 - Synthetic construct Homo sapiens clone ccsbBroadEn_01601 SSTR1 gene, encodes complete protein.
AB384936 - Synthetic construct DNA, clone: pF1KB4380, Homo sapiens SSTR1 gene for somatostatin receptor type 1, complete cds, without stop codon, in Flexi system.
DQ893328 - Synthetic construct clone IMAGE:100005958; FLH196205.01X; RZPDo839F04154D somatostatin receptor 1 (SSTR1) gene, encodes complete protein.
DQ896644 - Synthetic construct Homo sapiens clone IMAGE:100011104; FLH196201.01L; RZPDo839F04153D somatostatin receptor 1 (SSTR1) gene, encodes complete protein.
JD338992 - Sequence 320016 from Patent EP1572962.
JD073578 - Sequence 54602 from Patent EP1572962.
JD502529 - Sequence 483553 from Patent EP1572962.
JD521532 - Sequence 502556 from Patent EP1572962.
JD060146 - Sequence 41170 from Patent EP1572962.
JD055594 - Sequence 36618 from Patent EP1572962.
JD411583 - Sequence 392607 from Patent EP1572962.
JD148546 - Sequence 129570 from Patent EP1572962.
JD284705 - Sequence 265729 from Patent EP1572962.
JD469525 - Sequence 450549 from Patent EP1572962.
JD465227 - Sequence 446251 from Patent EP1572962.
JD495096 - Sequence 476120 from Patent EP1572962.
JD392772 - Sequence 373796 from Patent EP1572962.
JD271016 - Sequence 252040 from Patent EP1572962.
JD156166 - Sequence 137190 from Patent EP1572962.
JD406538 - Sequence 387562 from Patent EP1572962.
JD511314 - Sequence 492338 from Patent EP1572962.
JD307459 - Sequence 288483 from Patent EP1572962.
JD352654 - Sequence 333678 from Patent EP1572962.
JD093176 - Sequence 74200 from Patent EP1572962.
JD539069 - Sequence 520093 from Patent EP1572962.
JD203007 - Sequence 184031 from Patent EP1572962.
JD506480 - Sequence 487504 from Patent EP1572962.
JD266733 - Sequence 247757 from Patent EP1572962.
JD309654 - Sequence 290678 from Patent EP1572962.
JD103691 - Sequence 84715 from Patent EP1572962.
JD449408 - Sequence 430432 from Patent EP1572962.
JD510028 - Sequence 491052 from Patent EP1572962.
JD562988 - Sequence 544012 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

Reactome (by CSHL, EBI, and GO)

Protein P30872 (Reactome details) participates in the following event(s):

R-HSA-374758 Somatostatin receptors bind somatostatin and cortistatin
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000267377.1, ENST00000267377.2, NM_001049, P30872, SSR1_HUMAN, uc001wul.1, uc001wul.2, uc001wul.3
UCSC ID: ENST00000267377.3
RefSeq Accession: NM_001049
Protein: P30872 (aka SSR1_HUMAN)
CCDS: CCDS9666.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.